Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Cath Trigwell"'
Autor:
Stephen Green, Francisco Cruzalegui, Lara Ward, Sabina C. Cosulich, Marie Cumberbatch, Alys Jones, Rebecca Ellston, Lyndsey Hanson, Phillippa Dudley, Oona Delpuech, Alvaro Avivar-Valderas, Pablo Morentin Gutierrez, Myria Nikolaou, Urszula M. Polanska, Robert McEwen, Cath Trigwell, Urs J. Hancox, Kevin Hudson
Tumor cell line panel composition and growth inhibition sensitivity (GI50) to AZD8835.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d4782fd316b02ec8951d691e4f7122f
https://doi.org/10.1158/1535-7163.22507675.v1
https://doi.org/10.1158/1535-7163.22507675.v1
Autor:
Stephen Green, Francisco Cruzalegui, Lara Ward, Sabina C. Cosulich, Marie Cumberbatch, Alys Jones, Rebecca Ellston, Lyndsey Hanson, Phillippa Dudley, Oona Delpuech, Alvaro Avivar-Valderas, Pablo Morentin Gutierrez, Myria Nikolaou, Urszula M. Polanska, Robert McEwen, Cath Trigwell, Urs J. Hancox, Kevin Hudson
Details on PK / PD / efficacy modeling in BT474 xenograft model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c1af759ac8bbaffa0a90dd3c7be5a7
https://doi.org/10.1158/1535-7163.22507681
https://doi.org/10.1158/1535-7163.22507681
Autor:
Stephen Green, Francisco Cruzalegui, Lara Ward, Sabina C. Cosulich, Marie Cumberbatch, Alys Jones, Rebecca Ellston, Lyndsey Hanson, Phillippa Dudley, Oona Delpuech, Alvaro Avivar-Valderas, Pablo Morentin Gutierrez, Myria Nikolaou, Urszula M. Polanska, Robert McEwen, Cath Trigwell, Urs J. Hancox, Kevin Hudson
Full details on antibodies used in AZD8835 studies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20863bf8cc4a546f568da0ebc9da6eea
https://doi.org/10.1158/1535-7163.22507672.v1
https://doi.org/10.1158/1535-7163.22507672.v1
Autor:
Stephen Green, Francisco Cruzalegui, Lara Ward, Sabina C. Cosulich, Marie Cumberbatch, Alys Jones, Rebecca Ellston, Lyndsey Hanson, Phillippa Dudley, Oona Delpuech, Alvaro Avivar-Valderas, Pablo Morentin Gutierrez, Myria Nikolaou, Urszula M. Polanska, Robert McEwen, Cath Trigwell, Urs J. Hancox, Kevin Hudson
AZD8835 combination with SERDs (fulvestrant or AZD9496) results in tumor regression in mutant PIK3CA, ER+ breast xenografts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a278a4b9e9d1988ff44abfb5deec8a56
https://doi.org/10.1158/1535-7163.22507696
https://doi.org/10.1158/1535-7163.22507696
Autor:
Stephen Green, Francisco Cruzalegui, Lara Ward, Sabina C. Cosulich, Marie Cumberbatch, Alys Jones, Rebecca Ellston, Lyndsey Hanson, Phillippa Dudley, Oona Delpuech, Alvaro Avivar-Valderas, Pablo Morentin Gutierrez, Myria Nikolaou, Urszula M. Polanska, Robert McEwen, Cath Trigwell, Urs J. Hancox, Kevin Hudson
Details on cell lines used in AZD8835 selectivity profiling and efficacy studies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368519fee254b36a59f26a08302f86be
https://doi.org/10.1158/1535-7163.22507678
https://doi.org/10.1158/1535-7163.22507678
Autor:
Simon T. Barry, Stephen Green, Marie Cumberbatch, Emily Foster, Elizabeth A. Harrington, Barry R. Davies, Mandy Lawson, Steve Powell, Lara Ward, Stephen R. Wedge, Lillian Castriotta, Celina D'Cruz, Donald Ogilvie, Paul D. Smith, Martina Fitzek, Bernard Barlaam, Claire Crafter, Hannah Dry, Rebecca Ellston, Carol Lenaghan, Cath Trigwell, Lyndsey Hanson, Sabina Cosulich, Urs Hancox
Supplementary Materials text. Supplementary text to support supplementary data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc9bdcf5800ec6832230c58fa50deb2
https://doi.org/10.1158/1535-7163.22502410.v1
https://doi.org/10.1158/1535-7163.22502410.v1
Autor:
Simon T. Barry, Stephen Green, Marie Cumberbatch, Emily Foster, Elizabeth A. Harrington, Barry R. Davies, Mandy Lawson, Steve Powell, Lara Ward, Stephen R. Wedge, Lillian Castriotta, Celina D'Cruz, Donald Ogilvie, Paul D. Smith, Martina Fitzek, Bernard Barlaam, Claire Crafter, Hannah Dry, Rebecca Ellston, Carol Lenaghan, Cath Trigwell, Lyndsey Hanson, Sabina Cosulich, Urs Hancox
Supplementary Tables 1-3 and Figure 1-7. Supp Table 1 Summary of cell line origins and verification. Supp Table 2 Summary of antibodies used in all experimental analysis Supp Fig 1 AZD8186 inhibits PI3K pathway in PTEN null but not PTEN WT PIKC3A MT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1480195d4ae54dd467c3ee5679efbedf
https://doi.org/10.1158/1535-7163.22502407.v1
https://doi.org/10.1158/1535-7163.22502407.v1
Autor:
Stephen Green, Francisco Cruzalegui, Lara Ward, Sabina C. Cosulich, Marie Cumberbatch, Alys Jones, Rebecca Ellston, Lyndsey Hanson, Phillippa Dudley, Oona Delpuech, Alvaro Avivar-Valderas, Pablo Morentin Gutierrez, Myria Nikolaou, Urszula M. Polanska, Robert McEwen, Cath Trigwell, Urs J. Hancox, Kevin Hudson
Statistical analysis comparing efficacy between study arms of AZD8835 in vivo combination studies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f5dcb597635285bcc84dfe5eaf54d55
https://doi.org/10.1158/1535-7163.22507666
https://doi.org/10.1158/1535-7163.22507666
Autor:
Stephen Green, Francisco Cruzalegui, Lara Ward, Sabina C. Cosulich, Marie Cumberbatch, Alys Jones, Rebecca Ellston, Lyndsey Hanson, Phillippa Dudley, Oona Delpuech, Alvaro Avivar-Valderas, Pablo Morentin Gutierrez, Myria Nikolaou, Urszula M. Polanska, Robert McEwen, Cath Trigwell, Urs J. Hancox, Kevin Hudson
Body Weight time-courses for AZD8835 combination efficacy studies.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a4487bebaaac7cd7ee9efbb886b5eac
https://doi.org/10.1158/1535-7163.22507687
https://doi.org/10.1158/1535-7163.22507687
Autor:
Stephen Green, Francisco Cruzalegui, Lara Ward, Sabina C. Cosulich, Marie Cumberbatch, Alys Jones, Rebecca Ellston, Lyndsey Hanson, Phillippa Dudley, Oona Delpuech, Alvaro Avivar-Valderas, Pablo Morentin Gutierrez, Myria Nikolaou, Urszula M. Polanska, Robert McEwen, Cath Trigwell, Urs J. Hancox, Kevin Hudson
Contains Supplementary Material and Methods, Suuplementary Table & Figure Legends and Supplementary References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a15fde347f8aab2fa405869000ff754d
https://doi.org/10.1158/1535-7163.22507684
https://doi.org/10.1158/1535-7163.22507684