Výsledky vyhledávání - "Caterina Safina"

Akademický článek

Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism

Autor: James P Bridges, Caterina Safina, Bernard Pirard, Kari Brown, Alyssa Filuta, Ravichandran Panchanathan, Rochdi Bouhelal, Nicole Reymann, Sejal Patel, Klaus Seuwen, William E Miller, Marie-Gabrielle Ludwig

Publikováno v: eLife, Vol 11 (2022)

The mechanistic details of the tethered agonist mode of activation for the adhesion GPCR ADGRF5/GPR116 have not been completely deciphered. We set out to investigate the physiological importance of autocatalytic cleavage upstream of the agonistic pep

Externí odkaz: https://doaj.org/article/db418f7022854a65a93d19d7b20cf8f1

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Author response: Regulation of pulmonary surfactant by the adhesion GPCR GPR116/ADGRF5 requires a tethered agonist-mediated activation mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78f72459f53cc02ddc9fa397d6f768d7
https://doi.org/10.7554/elife.69061.sa2

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Targeting interleukin-4 to the arthritic joint

Autor: Lorenz Meinel, Janet Dawson, Tessa Lühmann, Amanda Littlewood-Evans, Bruno Tigani, Martina Raschig, Valerie Spieler, Marie-Gabrielle Ludwig, Hilmar Ebersbach, Caterina Safina, Björn ter Mors, Thomas Müller, Klaus Seuwen

Publikováno v: Journal of Controlled Release. 326:172-180

Anti-inflammatory cytokines are a promising class of therapeutics for treatment of rheumatoid arthritis (RA), but their use is currently limited by a rapid clearance and systemic toxicity. Interleukin-4 is a small cytokine with potential for RA thera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42ba66f3cba718f4e4dbe3cdc5422ff5
https://doi.org/10.1016/j.jconrel.2020.07.005

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