Stepwise Structural Simplification of the Dihydroxyanthraquinone Moiety of a Multitarget Rhein-Based Anti-Alzheimer Lead to Improve Drug Metabolism and Pharmacokinetic Properties

Autor: Caterina Pont, Anna Sampietro, F. Javier Pérez-Areales, Nunzia Cristiano, Agustí Albalat, Belén Pérez, Manuela Bartolini, Angela De Simone, Vincenza Andrisano, Marta Barenys, Elisabet Teixidó, Raimon Sabaté, M. Isabel Loza, José Brea, Diego Muñoz-Torrero

Publikováno v: Pharmaceutics, Vol 16, Iss 8, p 982 (2024)

Multitarget compounds have emerged as promising drug candidates to cope with complex multifactorial diseases, like Alzheimer’s disease (AD). Most multitarget compounds are designed by linking two pharmacophores through a tether chain (linked hybrid

Externí odkaz: https://doaj.org/article/5791f1c0c9d547149cf11ce0250bfaed

Design of Potential Antimalarial Agents Based on a Homology Model of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase

Autor: Caterina Pont, Nelson Alencar, Irene Sola, María Linares, Luca Di Palma, Carla Barbaraci, Cristina Sampedro, Jordi Juárez-Jiménez, Paloma Abad, Susana Pérez-Benavente, Jerónimo Lameira, José M. Bautista, F. Javier Luque, Diego Muñoz-Torrero

Publikováno v: Proceedings, Vol 1, Iss 6, p 665 (2017)

There currently exists a dire need for safe and inexpensive new antimalarial drugs, which are effective against multiple life cycle stages of Plasmodium falciparum, and act through mechanisms that differ from those of the available drugs to prevent d

Externí odkaz: https://doaj.org/article/f7924fcb0904490f8c4115706b902d34

Bacterial Inclusion Bodies for Anti-Amyloid Drug Discovery: Current and Future Screening Methods

Autor: Ana B. Caballero, Patrick Gamez, Raimon Sabaté, Maria Antònia Busquets, Diego Muñoz-Torrero, Caterina Pont, Joan Estelrich, Alba Espargaró

Publikováno v: Current Protein & Peptide Science. 20:563-576

Amyloid aggregation is linked to an increasing number of human disorders from nonneurological pathologies such as type-2 diabetes to neurodegenerative ones such as Alzheimer or Parkinson’s diseases. Thirty-six human proteins have shown the capacity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9bc9e6ae053283ed18c9ffddfa61b4
https://doi.org/10.2174/1389203720666190329120007

Evaluation of the effects of acetylcholinesterase inhibitors in the zebrafish touch-evoked response: quantitative vs. qualitative assessment

Autor: Jessica Legradi, Marta Barenys, Daniela Linares, Ann Cathrin Haigis, Manuela Bartolini, Lara González, Gisela Besa, Laura Guzman, Caterina Pont, Jesús Gómez-Catalán, Diego Muñoz-Torrero

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Environmental Sciences Europe, 32(1):145, 1-12. Springer Verlag
Environmental sciences Europe : ESEU 32(1), 145 (2020). doi:10.1186/s12302-020-00421-7
Guzman, L, Besa, G, Linares, D, González, L, Pont, C, Bartolini, M, Haigis, A C, Legradi, J, Muñoz-Torrero, D, Gómez-Catalán, J & Barenys, M 2020, ' Evaluation of the effects of acetylcholinesterase inhibitors in the zebrafish touch-evoked response : quantitative vs. qualitative assessment ', Environmental Sciences Europe, vol. 32, no. 1, 145, pp. 1-12 . https://doi.org/10.1186/s12302-020-00421-7

Environmental sciences Europe : ESEU 32(1), 145 (2020). doi:10.1186/s12302-020-00421-7
Published by Springer, Berlin ; Heidelberg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad1b0c7e3d5af4ab919d6bca4946377
http://hdl.handle.net/2445/171726

First homology model of Plasmodium falciparum glucose-6-phosphate dehydrogenase: Discovery of selective substrate analog-based inhibitors as novel antimalarial agents

Autor: F. Javier Luque, Cristina Sampedro, José M. Bautista, Antonio Viayna, Nelson Alencar, Jerônimo Lameira, Jordi Juárez-Jiménez, Diego Muñoz-Torrero, Caterina Pont, Irene Sola, Paloma Abad, David Vilchez, María Linares, Susana Pérez-Benavente

Publikováno v: European Journal of Medicinal Chemistry. 146:108-122

In Plasmodium falciparum the bifunctional enzyme glucose-6-phosphate dehydrogenase‒6-phosphogluconolactonase (PfG6PD‒6PGL) is involved in the catalysis of the first reaction of the pentose phosphate pathway. Since this enzyme has a key role in pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4149283f372b5293db5d9b1ed9d0808c
https://doi.org/10.1016/j.ejmech.2018.01.044