Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Caterina Migliorini"'
Autor:
Caterina Migliorini, Adalgisa Sinicropi, Marek Luczkowski, Daniela Valensin, Henryk Kozlowski
Publikováno v:
JBIC Journal of Biological Inorganic Chemistry. 19:635-645
Transmissible spongiform encephalopathies are associated with the misfolding of the cellular Prion Protein (PrP(C)) to an abnormal protein isoform, called scrapie prion protein (PrP(Sc)). The structural rearrangement of the fragment of N-terminal dom
Publikováno v:
Coordination Chemistry Reviews. 256:352-368
Metal ions, especially redox active copper, are thought to play critical roles in neurodegenerative disorders. As a matter of fact, metal binding may result into severe conformational changes of proteins involved in neurodegeneration. The present rev
Autor:
Elena Gaggelli, Elżbieta Jankowska, Daniela Valensin, Henryk Kozlowski, Gianni Valensin, Alina Marcinkowska, Caterina Migliorini, Pawel Stanczak
Publikováno v:
The Journal of Physical Chemistry B. 112:15140-15150
The unique biology of prion proteins (PrPs) allied with the public-health risks posed by prion zoonoses, such as various animal neurodegenerations, has focused much attention on the molecular basis of the controls cross-species and on the similaritie
Prion diseases, known as Transmissible Spongiform Encephalopathies (TSEs), are a group of fatal neuronal, and to some extent infectious disorders, associated with a pathogenic protein agent called prion protein (PrP). The human prion protein (hPrP) f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a11ed45f42f20bb4b3d93bbdd87b4483
http://hdl.handle.net/11365/980593
http://hdl.handle.net/11365/980593
Autor:
Gianni Valensin, Elena Molteni, Elena Gaggelli, Henryk Kozlowski, Caterina Migliorini, Daniela Valensin, Zbigniew Grzonka
Publikováno v:
Chem. Commun.. :341-343
The interaction between Cu(II) and the rat amyloid beta (1-28) fragment in micellar solutions at pH 7.5 was investigated by CD and NMR spectroscopy; the proton-copper distances were used in restrained molecular dynamics simulations to obtain a struct
Autor:
Gianni Valensin, Luigi Messori, Giovanni La Penna, Chiara Gabbiani, Caterina Migliorini, Daniela Valensin, Elena Gaggelli, Henryk Kozlowski
Publikováno v:
Inorganic chemistry 50 (2011): 6865–6867. doi:10.1021/ic201069v
info:cnr-pdr/source/autori:Valensin D., Migliorini C., Valensin G., Gaggelli E., La Penna G., Kozlowski H., Gabbiani C., Messori L./titolo:Exploring the reactions of beta-amyloid peptide 1-28 with Al(III) and Fe(III) ions/doi:10.1021%2Fic201069v/rivista:Inorganic chemistry/anno:2011/pagina_da:6865/pagina_a:6867/intervallo_pagine:6865–6867/volume:50
info:cnr-pdr/source/autori:Valensin D., Migliorini C., Valensin G., Gaggelli E., La Penna G., Kozlowski H., Gabbiani C., Messori L./titolo:Exploring the reactions of beta-amyloid peptide 1-28 with Al(III) and Fe(III) ions/doi:10.1021%2Fic201069v/rivista:Inorganic chemistry/anno:2011/pagina_da:6865/pagina_a:6867/intervallo_pagine:6865–6867/volume:50
The reactions of human beta-amyloid peptide 1-28 (A beta 28) with Al-III and Fe-III ions were investigated by H-1 NMR and electrospray ionization mass spectrometry (ESI-MS) under pH conditions close to physiological ones. H-1 NMR titrations, performe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f3e180889b8444b6973ae87926f012
http://www.cnr.it/prodotto/i/17082
http://www.cnr.it/prodotto/i/17082
Publikováno v:
Dalton transactions (Cambridge, England : 2003). 39(37)
The fragment of the zebrafish prion-like protein (PrP-rel-2), encompassing residues 74-86 and unprotected at N-terminus (zf74-86) represents a good model to understand Cu(2+) and Zn(2+) binding to ligands containing multi-potential metal donor sites.
Autor:
Elena Molteni, Anna Janicka-Klos, Ewa Wieczerzak, Caterina Migliorini, Gianni Valensin, Elżbieta Jankowska, Elena Gaggelli, Henryk Kozlowski, Daniela Valensin
Alzheimer's disease is a fatal neurodegenerative disorder involving the abnormal accumulation and deposition of peptides (amyloid-beta, Abeta) derived from the amyloid precursor protein. Here, we present the structure and the Zn2+ binding sites of hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977b8e63fb17846b302ff81dfbb9c5e1
http://hdl.handle.net/11365/25607
http://hdl.handle.net/11365/25607
Autor:
Francesco Berti, Henryk Kozlowski, Maurizio Remelli, Hanna Miecznikowska, Remo Guerrini, Anna Janicka, Elena Gaggelli, Caterina Migliorini, Anna Legowska, Gianni Valensin, Rebecca Pogni, Krzysztof Rolka, Daniela Valensin
Human prion protein (hPrP) fragments encompassing the 91-120 region, namely hPrP92-100 (SP1), hPrP106-113 (SP2), hPrP91-120 (LP1), and hPrP91-114 (LP2), were considered for delineation of the Cu(II)-binding site(s). NMR and EPR spectroscopy results o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f15c123b630f6d57e20f7be5aa9234d
http://hdl.handle.net/11392/521895
http://hdl.handle.net/11392/521895
Autor:
Ellena Gaggelli, Daniela Valensin, Caterina Migliorini, Gianni Valensin, Magdalena Świątek, Małgorzata Jeżowska-Bojczuk
Publikováno v:
Dalton transactions (Cambridge, England : 2003). (23)
Vancomycin, a “last chance” antibiotic, is a glycopeptide consisting of an oligopeptide unit being potentially the effective binder of Cu2+ ions. The potentiometric and spectroscopic studies (UV-Vis, CD, EPR, NMR) have shown that, indeed, the pep