Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Caterina Mancusi"'
Autor:
Georgia Zoumpoulidou, Carlos Alvarez-Mendoza, Caterina Mancusi, Ritika-Mahmuda Ahmed, Milly Denman, Christopher D. Steele, Maxime Tarabichi, Errin Roy, Lauren R. Davies, Jiten Manji, Camilla Cristalli, Katia Scotlandi, Nischalan Pillay, Sandra J. Strauss, Sibylle Mittnacht
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
RB1 mutations are seen in 40-60% of sporadic osteosarcoma. Here, the authors demonstrate a selective sensitivity to PARP inhibitors in RB1-mutated osteosarcoma-derived cell lines that is not associated with canonical signatures indicative of a homolo
Externí odkaz:
https://doaj.org/article/29d2b65339524853a5548dbf68b35ca4
Autor:
Steven R. Whittaker, Clare Barlow, Mathew P. Martin, Caterina Mancusi, Steve Wagner, Annette Self, Elaine Barrie, Robert Te Poele, Swee Sharp, Nathan Brown, Stuart Wilson, Wayne Jackson, Peter M. Fischer, Paul A. Clarke, Michael I. Walton, Edward McDonald, Julian Blagg, Martin Noble, Michelle D. Garrett, Paul Workman
Publikováno v:
Molecular Oncology, Vol 12, Iss 3, Pp 287-304 (2018)
Deregulation of the cyclin‐dependent kinases (CDKs) has been implicated in the pathogenesis of multiple cancer types. Consequently, CDKs have garnered intense interest as therapeutic targets for the treatment of cancer. We describe herein the molec
Externí odkaz:
https://doaj.org/article/fe1e3db27bb44f2e82c1a7b2ffc32006
Autor:
Caterina Mancusi, Milly Denman, Nischalan Pillay, Carlos Alvarez Mendoza, Georgia Zoumpoulidou, Jiten Manji, Sibylle Mittnacht, Christopher D. Steele, Ritika-Mahmuda Ahmed, Sandra J. Strauss
BackgroundLoss-of-function mutations of the retinoblastoma tumour suppressor RB1 are key drivers in cancer, with prominent involvement in the natural history of Osteosarcoma (OS). RB1 loss-of-function compromises genome maintenance in cells and hence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd7a18f8aaff360ea220df71e620f55
https://doi.org/10.21203/rs.3.rs-185226/v1
https://doi.org/10.21203/rs.3.rs-185226/v1
Autor:
Tomas Goncalves, Georgia Zoumpoulidou, Carlos Alvarez-Mendoza, Caterina Mancusi, Laura C. Collopy, Sandra J. Strauss, Sibylle Mittnacht, Kazunori Tomita
The Supporting Information is available free of charge at https://pubs.acs.org/doi/10.1021/acsptsci.0c00125. Origin and characteristics of the osteosarcoma cell lines, telomere length measurement from TRF, IC50 drug response in osteosarcoma cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446fe52d87a9d9046678ffd9d18f924f
https://bura.brunel.ac.uk/handle/2438/21626
https://bura.brunel.ac.uk/handle/2438/21626
Autor:
Laura C. Collopy, Carlos Alvarez-Mendoza, Sibylle Mittnacht, Kazunori Tomita, Caterina Mancusi, Sandra J. Strauss, Tomas Goncalves, Georgia Zoumpoulidou
Publikováno v:
ACS Pharmacology & Translational Science
To avoid replicative senescence or telomere-induced apoptosis, cancers employ telomere maintenance mechanisms (TMMs) involving either the upregulation of telomerase or the acquisition of recombination-based alternative telomere lengthening (ALT). The
Autor:
Giorgio Liguori, Adriana Franzese, Carmelina Sorrentino, Pierluigi Pecoraro, Francesca Gallè, Giuliana Valerio, Patrizia Calella, Serena Sensi, Caterina Mancusi, Maria Imoletti
Though classroom time has been identified as a contributing factor to sedentary behavior, school has been recognized as the main educational setting providing physical activity (PA) opportunities. The purpose of this study was to develop and evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b6a6f93afe491f06ad3acc5317cf38
http://hdl.handle.net/11588/770245
http://hdl.handle.net/11588/770245
Autor:
Pasqualina Buono, Valeria Gallarato, Giorgio Liguori, Luca Russomando, Caterina Mancusi, Roberto Mastronuzzi, Francesca Gallè, Giuliana Valerio, Domenico Martone
Publikováno v:
Sport Sciences for Health. 10:261-267
Physical fitness (PF) is considered an important health marker already in youth with positive influence on adult health. The aim of this study was to investigate the effects of overweight/obesity on most relevant health-related physical fitness (HRPF
Publikováno v:
Cancer Research. 79:380-380
Inhibitors of the Ataxia Telangiectasia and Rad3 related protein kinase (ATR) are increasingly entering clinical trials as single agents or in combination with inhibitors of poly (ADP-ribose) polymerases (PARPs), DNA-damaging chemotherapy or radiothe
Autor:
Steve Wagner, Georgios Vlachogiannis, Alexis De Haven Brandon, Melanie Valenti, Gary Box, Liam Jenkins, Caterina Mancusi, Annette Self, Floriana Manodoro, Ioannis Assiotis, Penny Robinson, Ritika Chauhan, Alistair G. Rust, Nik Matthews, Kate Eason, Khurum Khan, Naureen Starling, David Cunningham, Anguraj Sadanandam, Clare M. Isacke, Vladimir Kirkin, Nicola Valeri, Steven R. Whittaker
Publikováno v:
Oncogene. 38:5746-5746
A correction to this paper has been published and can be accessed via a link at the top of the paper.
Autor:
Dilia Giuggioli, Poupak Fallahi, Clodoveo Ferri, Michele Colaci, Silvia Martina Ferrari, Alessandro Antonelli, Caterina Mancusi
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 98:E1198-E1202
Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology, and several studies reported its association with thyroid autoimmune disorders. No study has evaluated longitudinally the incidence of new cases of thyroid autoimmunity and