Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Caterina M. Hernandez"'
Autor:
De-Huang Guo, Masaki Yamamoto, Caterina M. Hernandez, Hesam Khodadadi, Babak Baban, Alexis M. Stranahan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Visceral adiposity is a risk factor for cognitive decline, but subcutaneous adipose tissue (SAT) is not and may be protective. Here, the authors show that beige adipocytes are indispensable for the neuroprotective effects of SAT. Beige fat knockout m
Externí odkaz:
https://doaj.org/article/6a721c53c0ba40748c1d57563d2efd85
Publikováno v:
Brain and Behavior, Vol 11, Iss 2, Pp n/a-n/a (2021)
Abstract Introduction Several clinical studies have tested the efficacy of insulin‐sensitizing drugs for cognitive enhancement in Alzheimer's disease (AD) patients, as type 2 diabetes (T2D) is a well‐recognized risk factor for AD. Pilot studies a
Externí odkaz:
https://doaj.org/article/63337b9911b84d789804e345a135b7c4
Autor:
Alexis M. Stranahan, De-Huang Guo, Masaki Yamamoto, Caterina M. Hernandez, Hesam Khodadadi, Babak Baban, Wenbo Zhi, Yun Lei, Xinyun Lu, Kehong Ding, Carlos M. Isales
Preferential energy storage in subcutaneous adipose tissue (SAT) confers protection against obesity-induced pathophysiology in females. Females also exhibit distinct immunological responses, relative to males. These differences are often attributed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17dc653eadd357d1a0cd3115200ced12
https://doi.org/10.2337/figshare.21526683
https://doi.org/10.2337/figshare.21526683
Autor:
Caterina M. Hernandez, Masaki Yamamoto, Hesam Khodadadi, Babak Baban, De Huang Guo, Alexis M. Stranahan
Publikováno v:
J Clin Invest
Induction of the inflammasome protein cryopyrin (NLRP3) in visceral adipose tissue (VAT) promotes release of the proinflammatory cytokine IL-1β in obesity. Although this mechanism contributes to peripheral metabolic dysfunction, effects on the brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b55928913e0e1328a62dcc52a91294a
https://doi.org/10.1172/jci126078
https://doi.org/10.1172/jci126078
Autor:
Alexis M. Stranahan, Hesam Khodadadi, De-Huang Guo, Babak Baban, Masaki Yamamoto, Caterina M. Hernandez
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Visceral obesity increases risk of cognitive decline in humans, but subcutaneous adiposity does not. Here, we report that beige adipocytes are indispensable for the neuroprotective and anti-inflammatory effects of subcutaneous fat. Mice lacking funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e477534ab33e0d75402b0e7ddb6c5148
http://europepmc.org/articles/PMC8324783
http://europepmc.org/articles/PMC8324783
Publikováno v:
Brain and Behavior
Brain and Behavior, Vol 11, Iss 2, Pp n/a-n/a (2021)
Brain and Behavior, Vol 11, Iss 2, Pp n/a-n/a (2021)
Introduction Several clinical studies have tested the efficacy of insulin‐sensitizing drugs for cognitive enhancement in Alzheimer's disease (AD) patients, as type 2 diabetes (T2D) is a well‐recognized risk factor for AD. Pilot studies assessing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf36714d30668ce5372e11fada5cf88
https://doi.org/10.1002/brb3.1973
https://doi.org/10.1002/brb3.1973
Autor:
Anilkumar Pillai, Michael G. Bartlett, Xiangkun Yang, Indrani Poddar, Alvin V. Terry, Caterina M. Hernandez, Patrick M. Callahan
Publikováno v:
Pharmacology, biochemistry, and behavior. 197
Antipsychotic drugs (APDs) have a variety of important therapeutic applications for neuropsychiatric disorders. However, they are routinely prescribed off-label across all age categories, a controversial practice given their potential for producing m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318dde82faece89b5cc6f44bc3c84d41
https://pubmed.ncbi.nlm.nih.gov/32702397
https://pubmed.ncbi.nlm.nih.gov/32702397
Autor:
Indrani Poddar, Sean X. Naughton, Ping Chang Lin, Wayne D. Beck, Alvin V. Terry, Nathan Yanasak, Caterina M. Hernandez
Publikováno v:
Toxicology. :92-103
Organophosphates (OPs) are found in hundreds of valuable agricultural, industrial, and commercial compounds; however, they have also been associated with a variety of harmful effects in humans. The acute toxicity of OPs is attributed to the inhibitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcca4a9e446a1e0d05be9aa89fe79f28
https://doi.org/10.1016/j.tox.2018.06.004
https://doi.org/10.1016/j.tox.2018.06.004
Autor:
Michael G. Bartlett, Indrani Poddar, Caterina M. Hernandez, Alvin V. Terry, Xiangkun Yang, Patrick M. Callahan
Publikováno v:
Biochemical Pharmacology. 151:180-187
While impairments of cognition in schizophrenia have the greatest impact on long-term functional outcome, the currently prescribed treatments, antipsychotic drugs (APDs), do not effectively improve cognition. Moreover, while more than 20 years have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b0c6754a757d22ba5cac30a84e9a9e
https://doi.org/10.1016/j.bcp.2017.11.017
https://doi.org/10.1016/j.bcp.2017.11.017