CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease

Autor: Simone M. Crivelli, Qian Luo, Jo A.A. Stevens, Caterina Giovagnoni, Daan van Kruining, Gerard Bode, Sandra den Hoedt, Barbara Hobo, Anna-Lena Scheithauer, Jochen Walter, Monique T. Mulder, Christopher Exley, Matthew Mold, Michelle M. Mielke, Helga E. De Vries, Kristiaan Wouters, Daniel L. A. van den Hove, Dusan Berkes, María Dolores Ledesma, Joost Verhaagen, Mario Losen, Erhard Bieberich, Pilar Martinez-Martinez

Publikováno v: Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-21 (2021)

Abstract Background Dysregulation of ceramide and sphingomyelin levels have been suggested to contribute to the pathogenesis of Alzheimer’s disease (AD). Ceramide transfer proteins (CERTs) are ceramide carriers which are crucial for ceramide and sp

Externí odkaz: https://doaj.org/article/d634c5d563fa46608f8877609d288d6f

Sphingolipids in Alzheimer's disease, how can we target them?

Autor: Erhard Bieberich, Jochen Walter, Sandra den Hoedt, Monique T. Mulder, Mario Losen, Caterina Giovagnoni, Lars Visseren, Anna-Lena Scheithauer, Pilar Martinez-Martinez, Simone M. Crivelli, Nienke M. de Wit, Helga E. de Vries

Publikováno v: Crivelli, S M, Giovagnoni, C, Visseren, L, Scheithauer, A-L, de Wit, N, den Hoedt, S, Losen, M, Mulder, M T, Walter, J, de Vries, H E, Bieberich, E & Martinez-Martinez, P 2020, ' Sphingolipids in Alzheimer's disease, how can we target them? ', Advanced Drug Delivery Reviews, vol. 159, pp. 214-231 . https://doi.org/10.1016/j.addr.2019.12.003
Advanced Drug Delivery Reviews, 159, 214-231. Elsevier

Altered levels of sphingolipids and their metabolites in the brain, and the related downstream effects on neuronal homeostasis and the immune system, provide a framework for understanding mechanisms in neurodegenerative disorders and for developing n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc52d6b63486f0d3724ea03709659cb
https://pure.eur.nl/en/publications/b16984ac-dc9d-46e6-adb9-6b3b28f34874

CERTL reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease

Autor: Daan van Kruining, Anna-Lena Scheithauer, Pilar Martinez-Martinez, Barbara Hobo, Jochen Walter, Dušan Berkeš, Christopher Exley, Kristiaan Wouters, Mario Losen, Joost Verhaagen, Sandra den Hoedt, Caterina Giovagnoni, Maria Dolores Ledesma, Qian Luo, Matthew Mold, Michelle M. Mielke, Gerard H. Bode, Daniel L.A. van den Hove, Simone M. Crivelli, Jo Stevens, Helga E. de Vries, Erhard Bieberich, Monique T. Mulder

Publikováno v: Crivelli, S M, Luo, Q, Stevens, J A A, Giovagnoni, C, van Kruining, D, Bode, G, den Hoedt, S, Hobo, B, Scheithauer, A L, Walter, J, Mulder, M T, Exley, C, Mold, M, Mielke, M M, De Vries, H E, Wouters, K, van den Hove, D L A, Berkes, D, Ledesma, M D, Verhaagen, J, Losen, M, Bieberich, E & Martinez-Martinez, P 2021, ' CERT L reduces C16 ceramide, amyloid-β levels, and inflammation in a model of Alzheimer’s disease ', Alzheimer's Research and Therapy, vol. 13, no. 1, 45 . https://doi.org/10.1186/s13195-021-00780-0
Alzheimer's Research & Therapy, 13(1):45. BioMed Central Ltd
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-21 (2021)
Alzheimer's Research & Therapy, 13(1). BioMed Central
Alzheimer's Research and Therapy, 13(1):45. BioMed Central Ltd.
Alzheimer's Research and Therapy, 13(1):45. BioMed Central

BackgroundDysregulation of ceramide and sphingomyelin levels have been suggested to contribute to the pathogenesis of Alzheimer’s disease (AD). Ceramide transfer proteins (CERTs) are ceramide carriers which are crucial for ceramide and sphingomyeli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b490674ef4af7463e3b1e3e2ba1ec9
https://research.vu.nl/en/publications/4861577e-37b2-44d3-a5fe-3bb6f591f79f

Immunofluorescence Labeling of Lipid-Binding Proteins CERTs to Monitor Lipid Raft Dynamics

Autor: Caterina, Giovagnoni, Simone M, Crivelli, Mario, Losen, Pilar, Martinez-Martinez

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2187

Fluorescence microscopy is a powerful and widely used tool in molecular biology. Over the years, the discovery and development of lipid-binding fluorescent probes has established new research possibilities to investigate lipid composition and dynamic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b39fc8f37b91d02e309b202fe0478d8e
https://pubmed.ncbi.nlm.nih.gov/32770516

CERT

Autor: Simone M, Crivelli, Qian, Luo, Jo A A, Stevens, Caterina, Giovagnoni, Daan, van Kruining, Gerard, Bode, Sandra, den Hoedt, Barbara, Hobo, Anna-Lena, Scheithauer, Jochen, Walter, Monique T, Mulder, Christopher, Exley, Matthew, Mold, Michelle M, Mielke, Helga E, De Vries, Kristiaan, Wouters, Daniel L A, van den Hove, Dusan, Berkes, María Dolores, Ledesma, Joost, Verhaagen, Mario, Losen, Erhard, Bieberich, Pilar, Martinez-Martinez

Publikováno v: Alzheimer's Research & Therapy

Background Dysregulation of ceramide and sphingomyelin levels have been suggested to contribute to the pathogenesis of Alzheimer’s disease (AD). Ceramide transfer proteins (CERTs) are ceramide carriers which are crucial for ceramide and sphingomyel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::64460b0a220f2fa5a6f2551130a44fa6
https://pubmed.ncbi.nlm.nih.gov/33597019