Výsledky vyhledávání - "Caterina Giacomini"

Akademický článek

A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies

Autor: Caterina Giacomini, Chuay-Yeng Koo, Natalia Yankova, Ignatius A. Tavares, Selina Wray, Wendy Noble, Diane P. Hanger, Jonathan D. H. Morris

Publikováno v: Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-16 (2018)

Abstract In Alzheimer’s disease (AD) and related tauopathies, the microtubule-associated protein tau is highly phosphorylated and aggregates to form neurofibrillary tangles that are characteristic of these neurodegenerative diseases. Our previous w

Externí odkaz: https://doaj.org/article/6f252908efaa49e19f62165ab80a08c3

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Akademický článek

Lamin B1 levels modulate differentiation into neurons during embryonic corticogenesis

Autor: Sameehan Mahajani, Caterina Giacomini, Federica Marinaro, Davide De Pietri Tonelli, Andrea Contestabile, Laura Gasparini

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Abstract Lamin B1, a key component of the nuclear lamina, plays an important role in brain development. Ablation of endogenous Lamin B1 (Lmnb1) in the mouse strongly impairs embryonic brain development and corticogenesis. However, the mechanisms unde

Externí odkaz: https://doaj.org/article/946911ef6d464a83bd2e68edbd01b72d

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Akademický článek

Both Schwann cell and axonal defects cause motor peripheral neuropathy in Ebf2−/− mice

Autor: Caterina Giacomini, Veronica La Padula, Angelo Schenone, Massimo Leandri, Andrea Contestabile, Diego Moruzzo, Laurence Goutebroze, G. Giacomo Consalez, Fabio Benfenati, Anna Corradi

Publikováno v: Neurobiology of Disease, Vol 42, Iss 1, Pp 73-84 (2011)

Charcot–Marie–Tooth neuropathies are frequent hereditary disorders of the nervous system and most cases remain without a molecular definition. Mutations in transcription factors have been previously associated to various types of this disease. Mi

Externí odkaz: https://doaj.org/article/5f19c30212f146bb909b242fbb825746

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Akademický článek

Hyccin, the molecule mutated in the leukodystrophy hypomyelination and congenital cataract (HCC), is a neuronal protein.

Autor: Elisabetta Gazzerro, Simona Baldassari, Caterina Giacomini, Veronica Musante, Floriana Fruscione, Veronica La Padula, Roberta Biancheri, Sonia Scarfì, Valeria Prada, Federica Sotgia, Ian D Duncan, Federico Zara, Hauke B Werner, Michael P Lisanti, Lucilla Nobbio, Anna Corradi, Carlo Minetti

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e32180 (2012)

"Hypomyelination and Congenital Cataract", HCC (MIM #610532), is an autosomal recessive disorder characterized by congenital cataract and diffuse cerebral and peripheral hypomyelination. HCC is caused by deficiency of Hyccin, a protein whose biologic

Externí odkaz: https://doaj.org/article/90cf5623cd8e4b1dbfbd83a376bef951

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Supplementary Movie S2 from Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells

Autor: Jonathan D.H. Morris, Andrew N. Tutt, Spiros Linardopoulos, Charles M. Marson, Ignatius A. Tavares, Yolanda Olmos, Marta Reyes-Corral, Caterina Giacomini, Chuay-Yeng Koo

Live images of growing MCF-10A cells treated with compound 43. Representative time-lapse video images showing GFP-α-tubulin expressing MCF10-A cells incubated in growth medium containing compound 43 (5 µM) for 48 hours.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343cfa7530118221e29d23305a4f8bb8
https://doi.org/10.1158/1535-7163.22509819

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Supplementary Materials, Methods and Legends from Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells

Autor: Jonathan D.H. Morris, Andrew N. Tutt, Spiros Linardopoulos, Charles M. Marson, Ignatius A. Tavares, Yolanda Olmos, Marta Reyes-Corral, Caterina Giacomini, Chuay-Yeng Koo

Supplementary Materials, Methods and Legends

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f15aa36242e06bbd6ad39b8d1bacb25
https://doi.org/10.1158/1535-7163.22509825

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Supplementary Table S1 from Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells

Autor: Jonathan D.H. Morris, Andrew N. Tutt, Spiros Linardopoulos, Charles M. Marson, Ignatius A. Tavares, Yolanda Olmos, Marta Reyes-Corral, Caterina Giacomini, Chuay-Yeng Koo

Profile showing the activity of 70 different kinases in the presence of TAOK inhibitor compounds. In vitro kinase assays were carried out incubating kinases with or without compound 43 or 63 (0.3 µM) as indicated. Changes in the phosphorylation of M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d81a71feb9317bfb0f52f38e26a7bf1
https://doi.org/10.1158/1535-7163.22509810

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Targeting TAO kinases using a new inhibitor compound delays mitosis and induces mitotic cell death in centrosome amplified breast cancer cells

Autor: Andrew Tutt, Caterina Giacomini, Marta Reyes-Corral, Spiros Linardopoulos, Chuay Yeng Koo, I A Tavares, Charles M. Marson, Jonathan D.H. Morris, Yolanda Olmos

Publikováno v: Koo, C Y, Giacomini, C, Reyes-Corral, M, Olmos, Y, Tavares, I A, Marson, C M, Linardopoulos, S, Tutt, A N & Morris, J D H 2017, ' Targeting TAO kinases using a new inhibitor compound delays mitosis and induces mitotic cell death in centrosome amplified breast cancer cells ', MOLECULAR CANCER THERAPEUTICS, vol. 16, no. 11, pp. 2410-2421 . https://doi.org/10.1158/1535-7163.MCT-17-0077

Thousand-and-one amino acid kinases (TAOK) 1 and 2 are activated catalytically during mitosis and can contribute to mitotic cell rounding and spindle positioning. Here, we characterize a compound that inhibits TAOK1 and TAOK2 activity with IC50 value

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bc87413968d1753044a656bce4691e3
https://kclpure.kcl.ac.uk/ws/files/77615277/MCT_MERGED_LAST_SUBMISSION_JULY_25th.pdf

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Lamin B1 levels modulate differentiation into neurons during embryonic corticogenesis

Autor: Andrea Contestabile, Laura Gasparini, Sameehan Mahajani, Caterina Giacomini, Davide De Pietri Tonelli, Federica Marinaro

Publikováno v: Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)

Lamin B1, a key component of the nuclear lamina, plays an important role in brain development. Ablation of endogenous Lamin B1 (Lmnb1) in the mouse strongly impairs embryonic brain development and corticogenesis. However, the mechanisms underlying th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20645c399550d4c32cbdb0ffdfbd795d
http://europepmc.org/articles/PMC5501862

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