How Do Metal Ion Levels Change over Time in Hip Resurfacing Patients? A Cohort Study

Autor: Lucia Savarino, Matteo Cadossi, Eugenio Chiarello, Caterina Fotia, Michelina Greco, Nicola Baldini, Sandro Giannini

Publikováno v: The Scientific World Journal, Vol 2014 (2014)

Metal-on-metal hip resurfacing (MOM-HR) is offered as an alternative to traditional hip arthroplasty for young, active adults with advanced osteoarthritis. Nevertheless, concerns remain regarding wear and corrosion of the bearing surfaces and the res

Externí odkaz: https://doaj.org/article/a967664fc2734e3f936e3e40e293f6bb

Does chronic raise of metal ion levels induce oxidative DNA damage and hypoxia-like response in patients with metal-on-metal hip resurfacing?

Autor: Sandro Giannini, Lucia Savarino, M. Greco, Matteo Cadossi, Nicola Baldini, Caterina Fotia, Laura Roncuzzi

Publikováno v: Journal of Biomedical Materials Research Part B: Applied Biomaterials. 105:460-466

Metal-on-metal hip resurfacing (MOM-HR) represents a viable alternative to traditional arthroplasty. Nevertheless, in MOM coupling both metal nanoparticles and ions are released, whose toxicity remains a matter of concern. We investigated whether 'en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e64e99bec791789d7904cbb50c3293e2
https://doi.org/10.1002/jbm.b.33555

Prolonged Exposure to Hypoxic Milieu Improves the Osteogenic Potential of Adipose Derived Stem Cells

Autor: Caterina Fotia, Nicola Baldini, Filippo Boriani, Donatella Granchi, Annamaria Massa

Publikováno v: Journal of Cellular Biochemistry. 116:1442-1453

Mesenchymal stem cells (MSC) have been widely used in orthopedics for several applications. Conventionally, MSC are maintained under 21% O2 which does not reflect the real O2 tension in vivo. Recently, it was reported that different O2 conditions can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c1a9ca892018f0fd6a7d67ce9666c48
https://doi.org/10.1002/jcb.25106

V-ATPase as an effective therapeutic target for sarcomas

Autor: Katsuyuki Kusuzaki, Serena Rubina Baglìo, Francesca Perut, Shigekuni Hosogi, Sofia Avnet, Caterina Fotia, Manuela Salerno, Nicola Baldini

Publikováno v: Experimental Cell Research, 320(1), 21-32. Academic Press Inc.
Perut, F, Avnet, S, Fotia, C, Baglìo, S R, Salerno, M, Hosogi, S, Kusuzaki, K & Baldini, N 2014, ' V-ATPase as an effective therapeutic target for sarcomas ', Experimental Cell Research, vol. 320, no. 1, pp. 21-32 . https://doi.org/10.1016/j.yexcr.2013.10.011

Malignant tumors show intense glycolysis and, as a consequence, high lactate production and proton efflux activity. We investigated proton dynamics in osteosarcoma, rhabdomyosarcoma, and chondrosarcoma, and evaluated the effects of esomeprazole as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e59ffe66a55ae84a230ae7af1f1b056
http://www.scopus.com/inward/record.url?scp=84888176031&partnerID=8YFLogxK

Effects of hypoxia on osteogenic differentiation of mesenchymal stromal cells used as a cell therapy for avascular necrosis of the femoral head

Autor: Nicola Baldini, Lucia Savarino, Nicola Del Piccolo, Davide Maria Donati, Dante Dallari, Donatella Granchi, Gabriela Ciapetti, Caterina Fotia

Publikováno v: Cytotherapy. 18(9)

Background aims Avascular necrosis of the femoral head (AVN) occurs as common result of various conditions or develops as a primary entity, with a high freqency in young adults. Because of its tendency toward osteoarthritis requiring total hip arthro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05273b579a8d9d53d1e46aeb65b8c1f5
https://pubmed.ncbi.nlm.nih.gov/27421741