Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Caterina, Fattorusso"'
Autor:
Grazia Raffaella Tundo, Giuseppe Grasso, Marco Persico, Oleh Tkachuk, Francesco Bellia, Alessio Bocedi, Stefano Marini, Mariacristina Parravano, Grazia Graziani, Caterina Fattorusso, Diego Sbardella
Publikováno v:
Biomolecules, Vol 13, Iss 10, p 1492 (2023)
The insulin-degrading enzyme (IDE) is a Zn2+ peptidase originally discovered as the main enzyme involved in the degradation of insulin and other amyloidogenic peptides, such as the β-amyloid (Aβ) peptide. Therefore, a role for the IDE in the cure o
Externí odkaz:
https://doaj.org/article/faf2f74fbc4b43cdb79c98c5e36e62bf
Autor:
Marco Persico, Paola Galatello, Maria Grazia Ferraro, Carlo Irace, Marialuisa Piccolo, Avazbek Abduvakhidov, Oleh Tkachuk, Maria Luisa d’Aulisio Garigliota, Pietro Campiglia, Patrizia Iannece, Michela Varra, Anna Ramunno, Caterina Fattorusso
Publikováno v:
Molecules, Vol 28, Iss 10, p 4161 (2023)
A new series of tetrasubstituted pyrrole derivatives (TSPs) was synthesized based on a previously developed hypothesis on their ability to mimic hydrophobic protein motifs. The resulting new TSPs were endowed with a significant toxicity against human
Externí odkaz:
https://doaj.org/article/0232a63529d24e3f8387899bd8fb28f5
Autor:
Alessandro D’Urso, Roberto Purrello, Alessandra Cunsolo, Danilo Milardi, Caterina Fattorusso, Marco Persico, Maria Gaczynska, Pawel A. Osmulski, Anna Maria Santoro
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 704 (2023)
Many chronic diseases, including cancer and neurodegeneration, are linked to proteasome dysregulation. Proteasome activity, essential for maintaining proteostasis in a cell, is controlled by the gating mechanism and its underlying conformational tran
Externí odkaz:
https://doaj.org/article/48a23996892945a983b9cb65c3a7381c
Autor:
Andrea Galbiati, Aureliano Zana, Chiara Borsari, Marco Persico, Stefania Bova, Oleh Tkachuk, Alexandra Ioana Corfu, Lucia Tamborini, Nicoletta Basilico, Caterina Fattorusso, Stefano Bruno, Silvia Parapini, Paola Conti
Publikováno v:
Molecules, Vol 28, Iss 7, p 3172 (2023)
Chiral natural compounds are often biosynthesized in an enantiomerically pure fashion, and stereochemistry plays a pivotal role in biological activity. Herein, we investigated the significance of chirality for nature-inspired 3-Br-acivicin (3-BA) and
Externí odkaz:
https://doaj.org/article/640877a73467454187830b2b5472f319
Autor:
Marco Persico, Anna Maria Santoro, Alessandro D’Urso, Danilo Milardi, Roberto Purrello, Alessandra Cunsolo, Marina Gobbo, Roberto Fattorusso, Donatella Diana, Manuela Stefanelli, Grazia R. Tundo, Diego Sbardella, Massimo Coletta, Caterina Fattorusso
Publikováno v:
Biomolecules, Vol 12, Iss 6, p 741 (2022)
Cationic porphyrins exhibit an amazing variety of binding modes and inhibition mechanisms of 20S proteasome. Depending on the spatial distribution of their electrostatic charges, they can occupy different sites on α rings of 20S proteasome by exploi
Externí odkaz:
https://doaj.org/article/51cbf378c1fd41cb817e79e609766f02
Autor:
Giovanni Scambia, Giuseppe Campiani, Caterina Fattorusso, Marco Persico, Daniela Gallo, Simona Mozzetti, Carlo Bertucci, Samanta Cimitan, Silvia Bartollino, Giuseppina Raspaglio, Lucia Cicchillitti, Cristiano Ferlini
Supplementary Tables 1-3 from Paclitaxel Directly Binds to Bcl-2 and Functionally Mimics Activity of Nur77
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2143fb090015dc7bab071b0ec04e3a0d
https://doi.org/10.1158/0008-5472.22378748
https://doi.org/10.1158/0008-5472.22378748
Autor:
Giovanni Scambia, Giuseppe Campiani, Caterina Fattorusso, Marco Persico, Daniela Gallo, Simona Mozzetti, Carlo Bertucci, Samanta Cimitan, Silvia Bartollino, Giuseppina Raspaglio, Lucia Cicchillitti, Cristiano Ferlini
We reported previously that Bcl-2 is paradoxically down-regulated in paclitaxel-resistant cancer cells. We reveal here that paclitaxel directly targets Bcl-2 in the loop domain, thereby facilitating the initiation of apoptosis. Molecular modeling rev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ead0c99825c487f3659a76bd107582
https://doi.org/10.1158/0008-5472.c.6499004
https://doi.org/10.1158/0008-5472.c.6499004
Autor:
Marcello Casertano, Marialuisa Menna, Caterina Fattorusso, Nicoletta Basilico, Silvia Parapini, Marco Persico, Concetta Imperatore
Publikováno v:
Molecules, Vol 25, Iss 7, p 1530 (2020)
Malaria is a life-threatening disease and, what is more, the resistance to available antimalarial drugs is a recurring problem. The resistance of Plasmodium falciparum malaria parasites to previous generations of medicines has undermined malaria cont
Externí odkaz:
https://doaj.org/article/6c719ff3d9b644eab088a520ee0b80b2
Autor:
Concetta Imperatore, Roberto Gimmelli, Marco Persico, Marcello Casertano, Alessandra Guidi, Fulvio Saccoccia, Giovina Ruberti, Paolo Luciano, Anna Aiello, Silvia Parapini, Sibel Avunduk, Nicoletta Basilico, Caterina Fattorusso, Marialuisa Menna
Publikováno v:
Marine Drugs, Vol 18, Iss 2, p 112 (2020)
The chemical analysis of the sponge Dysidea avara afforded the known sesquiterpene quinone avarone, along with its reduced form avarol. To further explore the role of the thiazinoquinone scaffold as an antiplasmodial, antileishmanial and antischistos
Externí odkaz:
https://doaj.org/article/c93580dc6a934fa8a1887ddb21cc1626
Autor:
Lucio Annunziato, Elisa Perissutti, Giuseppe Pignataro, Paolo Luciano, Agnese Secondo, Valentina Tedeschi, Giuseppe Caliendo, Caterina Fattorusso, Vincenzo Santagada, Angela Corvino, Elisa Magli, Anna Pannaccione, Francesco Frecentese, Beatrice Severino, Ferdinando Fiorino, Marco Persico, Gianluca Esposito
Publikováno v:
Journal of Medicinal Chemistry
Due to the neuroprotective role of the Na+/Ca2+ exchanger (NCX) isoforms NCX1 and NCX3, we synthesized novel benzodiazepinone derivatives of the unique NCX activator Neurounina-1, named compounds 1-19. The derivatives are characterized by a benzodiaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f604e7dbeba7db0999359c15ef0f5fd9
http://europepmc.org/articles/PMC8713167
http://europepmc.org/articles/PMC8713167