Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Cate Speak"'
Autor:
Peter S. Linsley, Maki Nakayama, Elisa Balmas, Janice Chen, Fariba Barahmand-pour-Whitman, Shubham Bansal, Ty Bottorff, Elisavet Serti, Cate Speake, Alberto Pugliese, Karen Cerosaletti
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Human type 1 diabetes (T1D) is caused by autoimmune attack on the insulin-producing pancreatic beta cells by islet antigen-reactive T cells. How human islet antigen-reactive (IAR) CD4+ memory T cells from peripheral blood affect T1D progress
Externí odkaz:
https://doaj.org/article/66f2c80699f6498b86e42acf78ab840a
Autor:
Jamie L. Felton, Maria J. Redondo, Richard A. Oram, Cate Speake, S. Alice Long, Suna Onengut-Gumuscu, Stephen S. Rich, Gabriela S. F. Monaco, Arianna Harris-Kawano, Dianna Perez, Zeb Saeed, Benjamin Hoag, Rashmi Jain, Carmella Evans-Molina, Linda A. DiMeglio, Heba M. Ismail, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, John M. Wentworth, Kurt J. Griffin, Emily K. Sims, On behalf of the ADA/EASD PMDI
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-18 (2024)
Abstract Background Islet autoantibodies form the foundation for type 1 diabetes (T1D) diagnosis and staging, but heterogeneity exists in T1D development and presentation. We hypothesized that autoantibodies can identify heterogeneity before, at, and
Externí odkaz:
https://doaj.org/article/113aed4f5d484c8ca50fd405d635e3a3
Autor:
Sarah Alice Long, Virginia S. Muir, Britta E. Jones, Valerie Z. Wall, Alyssa Ylescupidez, Anne M. Hocking, Stephan Pribitzer, Jerill Thorpe, Bryce Fuchs, Alice E. Wiedeman, Megan Tatum, Katharina Lambert, Hannes Uchtenhagen, Cate Speake, Bernard Ng, Alexander T. Heubeck, Troy R. Torgerson, Adam K. Savage, Michael A. Maldonado, Neelanjana Ray, Vadim Khaychuk, Jinqi Liu, Peter S. Linsley, Jane H. Buckner
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Exhausted CD8 T cells (TEX) are associated with worse outcome in cancer yet better outcome in autoimmunity. Building on our past findings of increased TIGIT+KLRG1+ TEX with teplizumab therapy in type 1 diabetes (T1D), in the absence of treatment we f
Externí odkaz:
https://doaj.org/article/848afa4859044e9fb280078686f378e7
A standardized metric to enhance clinical trial design and outcome interpretation in type 1 diabetes
Autor:
Alyssa Ylescupidez, Henry T. Bahnson, Colin O’Rourke, Sandra Lord, Cate Speake, Carla J. Greenbaum
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The use of a standardized outcome metric enhances clinical trial interpretation and cross-trial comparison. If a disease course is predictable, comparing modeled predictions with outcome data affords the precision and confidence needed to ac
Externí odkaz:
https://doaj.org/article/bd672434f5da493f97ffb6f6a8e89aca
Autor:
Jamie L. Felton, Kurt J. Griffin, Richard A. Oram, Cate Speake, S. Alice Long, Suna Onengut-Gumuscu, Stephen S. Rich, Gabriela S. F. Monaco, Carmella Evans-Molina, Linda A. DiMeglio, Heba M. Ismail, Andrea K. Steck, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, Stephen Gitelman, John M. Wentworth, Maria J. Redondo, Emily K. Sims, ADA/EASD PMDI
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-16 (2023)
Abstract Background Type 1 diabetes (T1D) results from immune-mediated destruction of insulin-producing beta cells. Prevention efforts have focused on immune modulation and supporting beta cell health before or around diagnosis; however, heterogeneit
Externí odkaz:
https://doaj.org/article/2767b39b5fa44f12be12f5096aacf63d
Autor:
Jeremy R. B. Newman, S. Alice Long, Cate Speake, Carla J. Greenbaum, Karen Cerosaletti, Stephen S. Rich, Suna Onengut-Gumuscu, Lauren M. McIntyre, Jane H. Buckner, Patrick Concannon
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Genome-wide association studies have identified numerous loci with allelic associations to Type 1 Diabetes (T1D) risk. Most disease-associated variants are enriched in regulatory sequences active in lymphoid cell types, suggesting that lymph
Externí odkaz:
https://doaj.org/article/fc1b48b54b144defac7498b93b2a4cb1
Autor:
Carolina Acosta-Vega, David Skibinski, Anna Kus, Cate Speak, Alice Long, Uma Malhotra, Jane H Buckner, Alice Wiedeman
Publikováno v:
The Journal of Immunology. 206:62.13-62.13
During the Coronavirus Disease 2019 (COVID-19) outbreak, a robust and consistent strategy was required for assessing the immune landscape. Our rapid research response to COVID-19 was enabled by use of standardized assays. The assays included a 33-mar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08fb334b20078e27471efdfaf1df8a53
https://doi.org/10.4049/jimmunol.206.supp.62.13
https://doi.org/10.4049/jimmunol.206.supp.62.13
Autor:
Sarah E Holton, Mallorie Mitchem, Hamid Chalian, Sudhakar Pipavath, Eric D Morrell, Pavan K Bhatraju, Jessica A Hamerman, Cate Speake, Uma Malhotra, Mark M Wurfel, Steven E Ziegler, Carmen Mikacenic
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0285638 (2024)
Acute respiratory distress syndrome (ARDS) has a fibroproliferative phase that may be followed by pulmonary fibrosis. Pulmonary fibrosis following COVID-19 pneumonia has been described at autopsy and following lung transplantation. We hypothesized th
Externí odkaz:
https://doaj.org/article/bc9a11fe4f674f569d7165ab02b57dda
Autor:
Jillian R. Jaycox, Carolina Lucas, Inci Yildirim, Yile Dai, Eric Y. Wang, Valter Monteiro, Sandra Lord, Jeffrey Carlin, Mariko Kita, Jane H. Buckner, Shuangge Ma, Melissa Campbell, Albert Ko, Saad Omer, Carrie L. Lucas, Cate Speake, Akiko Iwasaki, Aaron M. Ring
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Whilst SARS-CoV-2 mRNA vaccines have demonstrated efficacy in reducing infection severity, research has shown that SARS-CoV-2 infection is associated with new autoantibodies. Whether this would also be observed during mRNA vaccination is unclear. Her
Externí odkaz:
https://doaj.org/article/3239ac58f1844ac3945c8c32a8186dce
Autor:
Elisa Balmas, Janice Chen, Alex K. Hu, Hannah A. DeBerg, Mario G. Rosasco, Vivian H. Gersuk, Elisavet Serti, Cate Speake, Carla J. Greenbaum, Gerald T. Nepom, Peter S. Linsley, Karen Cerosaletti
Publikováno v:
JCI Insight, Vol 8, Iss 21 (2023)
Variation in the preservation of β cell function in clinical trials in type 1 diabetes (T1D) has emphasized the need to define biomarkers to predict treatment response. The T1DAL trial targeted T cells with alefacept (LFA-3–Ig) and demonstrated C-
Externí odkaz:
https://doaj.org/article/fc5124fb6eab4bc1a3e7082177f0b113