Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant

Autor: Gabriela Alves de Souza, Soraia John da Silva, Catarina de Nigris Del Cistia, Paulo Pitasse-Santos, Lucas de Oliveira Pires, Yulli Moraes Passos, Yraima Cordeiro, Cristiane Martins Cardoso, Rosane Nora Castro, Carlos Mauricio R. Sant’Anna, Arthur Eugen Kümmerle

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 631-637 (2019)

A series of 3-substituted-7-aminoalcoxy-coumarin was designed and evaluated as cholinesterase inhibitors and antioxidants. All compounds were effective in inhibiting AChE with potencies in the nanomolar range. The 3-(4-(dimethylamino)phenyl)-7-aminoe

Externí odkaz: https://doaj.org/article/e9dead6f6ad94242a6049c23caa5acd4

Solvent-Free Synthesis, DNA-Topoisomerase II Activity and Molecular Docking Study of New Asymmetrically N,N'-Substituted Ureas

Autor: Aurea Echevarria, Carlos Maurício R. Sant'Anna, Catarina de Nigris Del Cistia, Daniel Rosa da Silva, Claudio E. Rodrigues-Santos, Andressa Esteves-Souza

Publikováno v: Molecules, Vol 17, Iss 11, Pp 12882-12894 (2012)

A new series of asymmetrically N,N'-substituted ureas 20–25 was prepared using solvent free conditions, which is an eco-friendly methodology, starting with Schiff bases derived from cinnamaldehyde and p-substituted anilines, which are subsequently

Externí odkaz: https://doaj.org/article/767608b250cd47fcade3e19df222e96c

Regioselective microwave synthesis and derivatization of 1,5-diaryl-3-amino-1,2,4-triazoles and a study of their cholinesterase inhibition properties

Autor: Arthur Eugen Kümmerle, Gabriela Alves de Souza, Renata Barbosa Lacerda, Thiago Moreira Pereira, Catarina de Nigris Del Cistia, Daiana Portella Franco, Sabrina Neves Santos, Carlos Mauricio R. Sant'Anna

Publikováno v: RSC advances. 9(35)

Herein we describe the development of an efficient one-pot regioselective synthesis protocol to obtain N-protected or N-deprotected 1,5-diaryl-3-amino-1,2,4-triazoles from N-acyl-N-Boc-carbamidothioates. This improved protocol using microwave irradia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::344df6ee72c4ab60787d3e805c5f31c7
https://pubmed.ncbi.nlm.nih.gov/35514684

Novel 3,4-methylenedioxyde-6-X-benzaldehyde-thiosemicarbazones: Synthesis and antileishmanial effects against Leishmania amazonensis

Autor: Aurea Echevarria, Cláudio E. Rodrigues-Santos, Catarina de Nigris Del Cistia, Viviane dos Santos Faiões, Eduardo Caio Torres-Santos, Carlos Mauricio R. Sant'Anna, Jorge Luiz R. de Melos

Publikováno v: European Journal of Medicinal Chemistry. 103:409-417

A series of eleven 3,4-methylenedioxyde-6-X-benzaldehyde-thiosemicarbazones (16–27) was synthesised as part of a study to search for potential new drugs with a leishmanicidal effect. The thiosemicarbazones, ten of which are new compounds, were prep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc809949b9d35e5ca9958f65992a805
https://doi.org/10.1016/j.ejmech.2015.09.009

The Effectiveness of Natural Diarylheptanoids against Trypanosoma cruzi: Cytotoxicity, Ultrastructural Alterations and Molecular Modeling Studies

Autor: Carlos Mauricio R. Sant´Anna, Catarina de Nigris Del Cistia, Adriano D. Andricopulo, Eliomara Sousa Sobral Alves, Marcos A. Vannier-Santos, Marco Edilson Freire de Lima, Debora Decote-Ricardo, Gustavo Peron Mendes-Silva, Luma G. Magalhães, Rosane Nora Castro, Celio Geraldo Freire-de-Lima, Vitor Sueth-Santiago, Julliane de Brito Braz Moraes

Publikováno v: PLoS ONE
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS ONE, Vol 11, Iss 9, p e0162926 (2016)

Curcumin (CUR) is the major constituent of the rhizomes of Curcuma longa and has been widely investigated for its chemotherapeutic properties. The well-known activity of CUR against Leishmania sp., Trypanosoma brucei and Plasmodium falciparum led us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7acfe3e999482c8b8414ceb2a637c99a
http://europepmc.org/articles/PMC5033595