The Enigmatic Canal-Associated Neurons Regulate Caenorhabditis elegans Larval Development Through a cAMP Signaling Pathway

Autor: Catarina Mörck, Sarah Grosche, Gian Garriga, Fred W. Wolf, Nebeyu Yosef, Jason Chien

Publikováno v: Genetics, vol 213, iss 4
Genetics

Caenorhabditis elegans larval development requires the function of the two Canal-Associated Neurons (CANs): killing the CANs by laser microsurgery or disrupting their development by mutating the gene ceh-10 results in early larval arrest. How these c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820f48d956d1851efcc4a69c3ea53c2f
https://escholarship.org/uc/item/5vd8p55t

The C. elegans M3 neuron guides the growth cone of its sister cell M2 via the Krüppel-like zinc finger protein MNM-2

Autor: Marc Pilon, Manish Rauthan, Catarina Mörck

Publikováno v: Developmental Biology. 311(1):185-199

The invariant cell-cell interactions occurring during C. elegans development offer unique opportunities to discover how growing axons may receive guidance cues from neighboring cells. The mnm-2 mutant was isolated because of its defects in the axon t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e70bb16883981e95627a7b21b606332

pha-2 encodes the C. elegans ortholog of the homeodomain protein HEX and is required for the formation of the pharyngeal isthmus

Autor: Fredrik Wågberg, Manish Rauthan, Marc Pilon, Catarina Mörck

Publikováno v: Developmental Biology. 272(2):403-418

The pha-2 mutant was isolated in 1993 by Leon Avery in a screen for worms with visible defects in pharyngeal feeding behavior. In pha-2 mutant worms, the pharyngeal isthmus is abnormally thick and short and, in contrast to wild-type worms, harbors se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1873c40336147130786a0f50327554

Caloric Restriction and Autophagy inCaenorhabditis elegans

Autor: Catarina Mörck, Marc Pilon

Publikováno v: BMC Developmental Biology

Background Mutations that cause feeding defects in the nematode C. elegans are known to increase life span. Here we show that feeding defective mutants also have a second general trait in common, namely that they are small. Results Our measurements o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b74613dab23c8e19009ed91ef1aaea7
https://doi.org/10.4161/auto.3418

Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans

Autor: Marc Pilon, Emma Svensson, Marika Hellqvist, Annika Enejder, Louise Cathrine Braun Olsen, Annelie Persson, Catarina Mörck, Nadia Jin Storm, Nils J. Færgeman, Caroline Kurth, John-Olov Jansson

Publikováno v: Mörck, C, Elmelund-Præstekær, L C B, Kurth, C, Persson, A, Storm, N J, Svensson, E, Jansson, J-O, Hellqvist, M, Enejder, A, Færgeman, N J & Pilon, M 2009, ' Statins inhibit protein lipidation and induce the unfolded protein response in the non-sterol producing nematode Caenorhabditis elegans ', Proceedings of the National Academy of Science of the United States of America, vol. 106, no. 43, pp. 18285-18290 . https://doi.org/10.1073/pnas.0907117106

Statins are compounds prescribed to lower blood cholesterol in millions of patients worldwide. They act by inhibiting HMG-CoA reductase, the rate-limiting enzyme in the mevalonate pathway that leads to the synthesis of farnesyl pyrophosphate, a precu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::782f59e759c943569bdb3c037ca62253
https://portal.findresearcher.sdu.dk/da/publications/33738b40-b9d0-11de-ab49-000ea68e967b