Direct recognition of an intact foreign protein by an αβ T cell receptor

Autor: Catarina F. Almeida, Benjamin S. Gully, Claerwen M. Jones, Lukasz Kedzierski, Sachith D. Gunasinghe, Michael T. Rice, Richard Berry, Nicholas A. Gherardin, Trang T. Nguyen, Yee-Foong Mok, Josephine F. Reijneveld, D. Branch Moody, Ildiko Van Rhijn, Nicole L. La Gruta, Adam P. Uldrich, Jamie Rossjohn, Dale I. Godfrey

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract αβ T cell receptors (αβTCRs) co-recognise antigens when bound to Major Histocompatibility Complex (MHC) or MHC class I-like molecules. Additionally, some αβTCRs can bind non-MHC molecules, but how much intact antigen reactivities are a

Externí odkaz: https://doaj.org/article/a4fb52352ddb44ba9d2176f3352758f0

Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors

Autor: Catarina F. Almeida, Srinivasan Sundararaj, Jérôme Le Nours, T. Praveena, Benjamin Cao, Satvika Burugupalli, Dylan G. M. Smith, Onisha Patel, Manfred Brigl, Daniel G. Pellicci, Spencer J. Williams, Adam P. Uldrich, Dale I. Godfrey, Jamie Rossjohn

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Natural killer T (NKT) cells include type I that express semi-invariant T cell receptor (TCR), and type II that cover a broader repertoire. Here the authors describe the crystal structure of a type II NKT TCR complexed with CD1d/antigen to propose th

Externí odkaz: https://doaj.org/article/d1409e5d6e6042d8b4b0882766610142

MAIT cells contribute to protection against lethal influenza infection in vivo

Autor: Bonnie van Wilgenburg, Liyen Loh, Zhenjun Chen, Troi J. Pediongco, Huimeng Wang, Mai Shi, Zhe Zhao, Marios Koutsakos, Simone Nüssing, Sneha Sant, Zhongfang Wang, Criselle D’Souza, Xiaoxiao Jia, Catarina F. Almeida, Lyudmila Kostenko, Sidonia B. G. Eckle, Bronwyn S. Meehan, Axel Kallies, Dale I. Godfrey, Patrick C. Reading, Alexandra J. Corbett, James McCluskey, Paul Klenerman, Katherine Kedzierska, Timothy S. C. Hinks

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)

MAIT cells are abundant in the lungs and confer protection against bacterial pathogens. Whilst activation of these cells has been described during viral infections, here van Wilgenburg and colleagues show that in a murine model MAIT cells contribute

Externí odkaz: https://doaj.org/article/e15ac8dd044648a69319eb56458d539f

Benzofuran sulfonates and small self-lipid antigens activate type II NKT cells via CD1d

Autor: Catriona V. Nguyen-Robertson, Spencer J. Williams, D. Branch Moody, Shihan Li, Dale I. Godfrey, Sidonia B G Eckle, Dylan G.M. Smith, Tan-Yun Cheng, Tram Nguyen, Scott J. J. Reddiex, Christopher M. Harpur, Jamie Rossjohn, Elena Batleska, Tamara Thelemann, Adam P Uldrich, Ildiko Van Rhijn, Daniel G. Pellicci, Catarina F. Almeida

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 118(34), 1. National Academy of Sciences
Proc Natl Acad Sci U S A

Natural killer T (NKT) cells detect lipids presented by CD1d. Most studies focus on type I NKT cells that express semi-invariant αβ T cell receptors (TCR) and recognize α-galactosylceramides. However, CD1d also presents structurally distinct lipid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620121843dcda6f950fef0976d9dfa78
https://doi.org/10.1073/pnas.2104420118

CD36 family members are TCR-independent ligands for CD1 antigen-presenting molecules

Autor: K. H. Gourley, Daniel G. Pellicci, R. De Rose, Catriona V. Nguyen-Robertson, Nicholas A Gherardin, Shihan Li, Hamish E G McWilliam, Jose A Villadangos, Dale I. Godfrey, Adam P Uldrich, Shian Su, DB Moody, Rebecca Seneviratna, Matthew E. Ritchie, Samuel J. Redmond, Catarina F. Almeida

CD1c presents lipid-based antigens to CD1c-restricted T cells which are thought to be a major component of the human T cell pool. The study of CD1c-restricted T cells, however, is hampered by the presence of an abundantly expressed CD1c-binding partn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b9901e8625f43e0d2cd9802ee12b263
https://doi.org/10.1101/2021.03.10.434884