Zobrazeno 1 - 10
of 197
pro vyhledávání: '"Catarina Brito"'
Autor:
Catarina M. Gomes, Maria João Sebastião, Gabriela Silva, Filipa Moura, Daniel Simão, Patrícia Gomes-Alves, Paula M. Alves, Catarina Brito
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Introduction: Engineered 3D models employing human induced pluripotent stem cell (hiPSC) derivatives have the potential to recapitulate the cell diversity and structure found in the human central nervous system (CNS). Therefore, these complex cellula
Externí odkaz:
https://doaj.org/article/0f7b8e5722b64a128671efc652b70aa4
Publikováno v:
Portuguese Journal of Pediatrics, Vol 55, Iss 1 (2024)
Cell degeneration of the enamel’s starry reticulum gives rise to the primary cyst before the mineralized tissue is formed. This cyst appears in place of a normal, un-erupted or supra-numerous teeth and is frequently observed among young people in m
Externí odkaz:
https://doaj.org/article/afc5b1bad9f340d592530dd7bc90ce95
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe clinical prognosis of the HER2-overexpressing (HER2-OE) subtype of breast cancer (BC) is influenced by the immune infiltrate of the tumor. Specifically, monocytic cells, which are promoters of pro-tumoral immunosuppression, and NK cel
Externí odkaz:
https://doaj.org/article/fc659e035e6d4e68ba2a754c63433e51
Autor:
Akash Khandelwal, Francisca Arez, Paula M. Alves, Lassina Badolo, Catarina Brito, Christoph Fischli, Diana Fontinha, Claude Oeuvray, Miguel Prudêncio, Matthias Rottmann, Justin Wilkins, Özkan Yalkinoglu, Wilhelmina M. Bagchus, Thomas Spangenberg
Publikováno v:
Malaria Journal, Vol 21, Iss 1, Pp 1-7 (2022)
Abstract Background Targeting the asymptomatic liver stage of Plasmodium infection through chemoprevention could become a key intervention to reduce malaria-associated incidence and mortality. Methods M5717, a Plasmodium elongation factor 2 inhibitor
Externí odkaz:
https://doaj.org/article/1a184acca8e44dcf9fd53edb5f8e0845
Autor:
Fernanda Silva, Filipa Coelho, Ana Peixoto, Pedro Pinto, Carmo Martins, Ann-Sophie Frombach, Vítor E. Santo, Catarina Brito, António Guimarães, Ana Félix
Publikováno v:
Cancer Cell International, Vol 22, Iss 1, Pp 1-17 (2022)
Highlights IPOLFG-SOC43 cell line represents the heterogeneity of Epithelial Ovarian Cancer Genetic alterations in cancer cells confer a selective advantage 3D cultures preserve the phenotypical features of the original tumor
Externí odkaz:
https://doaj.org/article/71cd59d565b44b1b83724cd94dc06196
Autor:
Megan C. Cox, Rita Mendes, Fernanda Silva, Teresa F. Mendes, Adelyn Zelaya-Lazo, Kathleen Halwachs, Julie J. Purkal, Inês A. Isidro, Ana Félix, Erwin R. Boghaert, Catarina Brito
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The current standard preclinical oncology models are not able to fully recapitulate therapeutic targets and clinically relevant disease biology, evidenced by the 90% attrition rate of new therapies in clinical trials. Three-dimensional (3D)
Externí odkaz:
https://doaj.org/article/6ba6021cf4734f4ebc89722a5ae55c02
Autor:
Ana Luísa Cartaxo, Jaime Almeida, Emilio J. Gualda, Maria Marsal, Pablo Loza-Alvarez, Catarina Brito, Inês A. Isidro
Publikováno v:
BMC Bioinformatics, Vol 21, Iss 1, Pp 1-19 (2020)
Abstract Background Antibodies revolutionized cancer treatment over the past decades. Despite their successfully application, there are still challenges to overcome to improve efficacy, such as the heterogeneous distribution of antibodies within tumo
Externí odkaz:
https://doaj.org/article/df4bf2858d754636adb4c2d6c8f2e02d
Autor:
Ana Luísa Cartaxo, Marta F. Estrada, Giacomo Domenici, Ruben Roque, Fernanda Silva, Emilio J. Gualda, Pablo Loza-Alvarez, George Sflomos, Cathrin Brisken, Paula M. Alves, Saudade André, Catarina Brito
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-14 (2020)
Abstract Background Estrogen receptor α (ERα) signaling is a defining and driving event in most breast cancers; ERα is detected in malignant epithelial cells of 75% of all breast cancers (classified as ER-positive breast cancer) and, in these case
Externí odkaz:
https://doaj.org/article/fc981856c13b4158bcfc1adff2fdfb38
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
Endothelial cells (ECs) are an important component of the tumor microenvironment, playing key roles in tumor development and progression that span from angiogenesis to immune regulation and drug resistance. Heterotypic tumor spheroids are one of the
Externí odkaz:
https://doaj.org/article/b6b29b156f1f4c86909cf3a8ddead809
Autor:
João Vasconcelos E Sá, Daniel Simão, Ana P Terrasso, Marta M Silva, Catarina Brito, Inês A Isidro, Paula M Alves, Manuel J T Carrondo
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 4, p e1007780 (2020)
Metabolism plays an essential role in cell fate decisions. However, the methods used for metabolic characterization and for finding potential metabolic regulators are still based on characterizing cellular metabolic steady-state which is dependent on
Externí odkaz:
https://doaj.org/article/9b3b68e0e4e940bfb6016c23fac899e2