Increased SGK1 activity potentiates mineralocorticoid/NaCl-induced kidney injury

Autor: Esteban Porrini, Ana Rodríguez-Rodríguez, Diego Alvarez de la Rosa, Silvia Velazquez-Garcia, Guadalberto Hernández, Ayse Gokce Keskus, Catalina Sierra-Ramos, Sergio Luis-Lima, Ozlen Konu, Juan F. Navarro-González, Arianna Vastola-Mascolo

Publikováno v: American Journal of Physiology: Renal Physiology

Serum and glucocorticoid-regulated kinase 1 (SGK1) stimulates aldosterone-dependent renal Na reabsorption and modulates blood pressure. In addition, genetic ablation or pharmacological inhibition of SGK1 limits the development of kidney inflammation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77afcbca489a39f585089a04d6670bcb
https://doi.org/10.1152/ajprenal.00505.2020

SGK1 activation exacerbates diet-induced obesity, metabolic syndrome and hypertension

Autor: Catalina Sierra-Ramos, Diego Alvarez de la Rosa, Guadalberto Hernández, Nourdine Faresse, Silvia Velazquez-Garcia, Arianna Vastola-Mascolo

The serum- and glucocorticoid-induced kinase 1 (SGK1) is a transcriptional target of steroid hormones including glucocorticoids or aldosterone in addition to other stimuli such as glucose. SGK1 is activated via phosphoinositide 3-kinase, placing it d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144ebc83746ae9d5387280c4245356b6
https://www.zora.uzh.ch/id/eprint/176831/

SAT-153 Role Of Increased Serum- And Glucocorticoid-inducible Kinase 1 (SGK1) Activity In Gluconeogenesis And Liver Metabolism During Metabolic Syndrome

Autor: Arianna Vastola, Silvia Velazquez-Garcia, Guadalberto Hernández, Catalina Sierra-Ramos, Diego Alvarez de la Rosa

Publikováno v: Journal of the Endocrine Society

SGK1 is a serine/threonine kinase expressed in different tissues included liver. At the cellular level, SGK1 expression is upregulated by multiple stimuli including gluco- and mineralo-corticoids, glucose and growth factors. Its activation depends on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032da0f24fa141aeb1b784010e086015
http://europepmc.org/articles/PMC6551854

Adipocyte Mineralocorticoid Receptor Activation Leads to Metabolic Syndrome and Induction of Prostaglandin D2 Synthase

Autor: Didier Quilliot, Catalina Sierra-Ramos, Alessandra Feraco, Soumaya El Mogrhabi, Riccardo Urbanet, Rhian M. Touyz, Aurelie Nguyen Dinh Cat, Nicolas Venteclef, Francesco Fallo, Gail K. Adler, Frederic Jaisser, Diego Alvarez de la Rosa, Patrick Rossignol

Publikováno v: Hypertension
Hypertension, American Heart Association, 2015, 66 (1), pp.149-157. ⟨10.1161/HYPERTENSIONAHA.114.04981⟩
Hypertension, 2015, 66 (1), pp.149-157. ⟨10.1161/HYPERTENSIONAHA.114.04981⟩

Metabolic syndrome is a major risk factor for the development of diabetes mellitus and cardiovascular diseases. Pharmacological antagonism of the mineralocorticoid receptor (MR), a ligand-activated transcription factor, limits metabolic syndrome in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f955be3aa01ea5b4281755f80e8acf11
https://hal.univ-lorraine.fr/hal-01659124

Aldosterone-specific activation of cardiomyocyte mineralocorticoid receptor in vivo

Autor: Jean-Marie Launay, Jane-Lise Samuel, Antoine Ouvrard-Pascaud, Nicolette Farman, Catalina Sierra-Ramos, Véronique Pelloux, Karine Clément, Smail Messaoudi, Claude Delcayre, Frederic Jaisser, Antoine Tarjus, Diego Alvarez de la Rosa, Basile Gravez

Publikováno v: Hypertension (Dallas, Tex. : 1979). 61(2)

Inappropriate mineralocorticoid receptor (MR) activation is involved in cardiac diseases. Whether and how aldosterone is involved in the deleterious effects of cardiac mineralocorticoid activation is still unclear. Mice overexpressing MR in cardiomyo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::524c470209ca6f47c661138885b48c86
https://pubmed.ncbi.nlm.nih.gov/23297371