Phagosomal granulocytic ROS in septic patients induce the bacterial SOS response

Autor: Stecy Chollet, Ana Catalina Hernandez Padilla, Thomas Daix, Margaux Gaschet, Bruno François, Christophe Piguet, Nathalie Gachard, Sandra Da Re, Robin Jeannet, Marie-Cécile Ploy

Publikováno v: iScience, Vol 27, Iss 6, Pp 109825- (2024)

Summary: Septic patients with worst clinical prognosis have increased circulating immature granulocytes (IG), displaying limited phagocytosis and reactive oxygen species (ROS) production. Here, we developed an ex vivo model of incubation of human gra

Externí odkaz: https://doaj.org/article/076484d225a9442a936637e93c4125a7

Immature granulocytes can help the diagnosis of pulmonary bacterial infections in patients with severe COVID-19 pneumonia

Autor: Thomas Daix, Robin Jeannet, Ana Catalina Hernandez Padilla, Philippe Vignon, Jean Feuillard, Bruno François

Publikováno v: Journal of Intensive Care, Vol 9, Iss 1, Pp 1-5 (2021)

Abstract During COVID-19, immature granulocyte (IG) concentration is heterogeneous with higher concentrations than those found in bacterial sepsis. We investigated the relationship between IG levels at ICU admission and on days 7 (± 2) and 15 (± 2)

Externí odkaz: https://doaj.org/article/3e423f1ddff64816870bd5bfb22f5573

Is prehospital endobronchial intubation a risk factor for subsequent ventilator associated pneumonia? A retrospective analysis.

Autor: Ana Catalina Hernandez Padilla, Timothée Trampont, Thomas Lafon, Thomas Daix, Dominique Cailloce, Olivier Barraud, François Dalmay, Philippe Vignon, Bruno François

Publikováno v: PLoS ONE, Vol 14, Iss 5, p e0217466 (2019)

More than half of patients under mechanical ventilation in the intensive care unit (ICU) are field-intubated, which is a known risk factor for ventilator associated pneumonia (VAP). We assessed whether field endobronchial intubation (EBI) is associat

Externí odkaz: https://doaj.org/article/52ab3b64c5cf40f7956b2e76c31f6a21

Comparative Early Hemodynamic Profiles in Patients Presenting to the Emergency Department with Septic and Nonseptic Acute Circulatory Failure Using Focused Echocardiography

Autor: Thomas Lafon, Bruno Evrard, Vincent Legarcon, Mathilde Hadj, Marine Goudelin, Paul Claveries, Philippe Vignon, Alexandra Appert, Ana Catalina Hernandez Padilla, Arthur Baisse, Vincent Bigrat

Publikováno v: Shock (Augusta, Ga.)

Study Objective: We evaluated the early hemodynamic profile of patients presenting with acute circulatory failure to the Emergency Department (ED) using focused echocardiography performed by emergency physicians after a dedicated training program. Me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d36ceb7a3e7fbf9bb68ca37d6d95796
http://europepmc.org/articles/PMC7237072

Efficacy and safety of suvratoxumab for prevention of Staphylococcus aureus ventilator-associated pneumonia (SAATELLITE)

Autor: Saad Nseir, Thierry Boulain, Georgios Baltopoulos, Julie Vignaud, Adel Maamar, Kathryn Shoemaker, Bertrand Souweine, Frédéric Dailler, Pierre-François Laterre, Pedro Moura, Jacques Creteur, Lucia Viña Soria, Terramika Bellamy, Andreas Meier-Hellmann, Alain Mercat, Matthias Gründling, Johann Motsch, Djillali Annane, Paula Ramirez, Christophe Guitton, Antonio Torres Marti, Marco Maggiorini, Tomas Suchy, Alain Lepape, Petr Svoboda, Michal Hanauer, Jan Pachl, Martin Balik, Jérôme Pugin, Jean-Christophe Navellou, Miguel Sánchez-García, Laurent Argaud, Arnaud Desachy, Vasilios Koulouras, Jean-Luc Pagani, Raúl De Pablo Sanchez, Pierre-François Dequin, Carole Schwebel, Ana Catalina Hernandez Padilla, Georgios Filntisis, Patrick Biston, Tomas Vymazal, Juan Carlos Valia, Vadryn Pierre, Frank E. J. Coenjaerts, Frank Wappler, Vladimir Sramek, Fabienne Tamion, Ildikó Krémer, Hasan S Jafri, Zsuzsa Marjanek, Didier Chochrad, Jose Lorente, Marc Simon, Herbert Spapen, Juan Carlos Montejo González, Omar Ali, Cédric Bretonnière, Maria Consuelo Pintado Delgado, Filip Dubovsky, Leen Timbermont, Apostolos Komnos, Christine Lammens, Pin Ren, Tobias Welte, Spyros Zakynthinos, Olivier Barraud, Tomas Hruby, Alain Dive, Herman Goossens, Alexey Ruzin, Marc J. M. Bonten, Ricard Ferrer Roca, Lorenz Reill, Yves Bouckaert, Epaminondas Zakynthinos, Zoltán Szentkereszty, Oliver A. Cornely, Josep Trenado, Antoine Gros, Marc Bourgeois, Ferhat Meziani, Katrin Schmidt, Bruno François, Philippe Eggimann, Ioanna Soultati, Jean-Marc Tadie, Frank Bloos, Agnes Sarkany, Francis Schneider, Susan Colbert, Maria Deja, Mark T. Esser, Gilles Francony, Caroline Rolfes, Martin Nováček, Ana Loza Vazquez, Yuling Wu, Jean-Yves Lefrant, Dolores Escudero, Jean Chastre, Frédéric Foret, René Robert, Vasileios Bekos, Vincent Huberlant, Ioannis Pnevmatikos

Publikováno v: The lancet infectious diseases
The Lancet. Infectious diseases, Vol. 21, no.9, p. 1313-1323 (2021)

Summary Background Staphylococcus aureus remains a common cause of ventilator-associated pneumonia, with little change in incidence over the past 15 years. We aimed to evaluate the efficacy of suvratoxumab, a monoclonal antibody targeting the α toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b15ccdd46639f0fdf9639d0d5e7f317
https://biblio.vub.ac.be/vubir/(5cde9a53-ceeb-4295-8185-cc8c8f24c7f3).html