MAST CELLS AND MAST CELL PRECURSORS ACCUMULATE IN THE PATHOGENIC ALZHEIMER’S DISEASE BRAIN

Autor: Emiliano Trias, Mariángeles Kovacs, Catalina Alamón, Lucas Tarragó, Valentina Varela, Cecilia Maciel, Benoît Delatour, Olivier Hermine, Luis Barbeito

Publikováno v: IBRO Neuroscience Reports, Vol 15, Iss , Pp S507-S508 (2023)

Externí odkaz: https://doaj.org/article/8d363bcd46124704a1ebe8a4cb63af6e

Closo-Carboranyl- and Metallacarboranyl [1,2,3]triazolyl-Decorated Lapatinib-Scaffold for Cancer Therapy Combining Tyrosine Kinase Inhibition and Boron Neutron Capture Therapy

Autor: Marcos Couto, Catalina Alamón, María Fernanda García, Mariángeles Kovacs, Emiliano Trias, Susana Nievas, Emiliano Pozzi, Paula Curotto, Silvia Thorp, María Alejandra Dagrosa, Francesc Teixidor, Clara Viñas, Hugo Cerecetto

Publikováno v: Cells, Vol 9, Iss 6, p 1408 (2020)

One of the driving forces of carcinogenesis in humans is the aberrant activation of receptors; consequently, one of the most promising mechanisms for cancer treatment is receptor inhibition by chemotherapy. Although a variety of cancers are initially

Externí odkaz: https://doaj.org/article/35b73e026e414961b9a8cebd8b962df2

A Potential Boron Neutron Capture Therapy Agent Selectively Suppresses High-Grade Glioma: In Vitro and in Vivo Exploration

Autor: Catalina Alamón, Belén Dávila, María Fernanda García, Susana Nievas, María Alejandra Dagrosa, Silvia Thorp, Mariángeles Kovacs, Emiliano Trias, Ricardo Faccio, Martín Gabay, Nidal Zeineh, Abraham Weizman, Francesc Teixidor, Clara Viñas, Moshe Gavish, Hugo Cerecetto, Marcos Couto

Glioblastoma (GBM), as the most central nervous system (CNS) intractable disease, has spoiled millions of lives due to its high mortality. Even though several efforts have been made, the existing treatments have had limited success. In this sense, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32b346c7445f1350ce61db86da99f86
http://hdl.handle.net/10261/329781

PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical β-coronavirus disease

Autor: Maite Duhalde Vega, Daniela Olivera, Gustavo Gastão Davanzo, Mauricio Bertullo, Verónica Noya, Gabriela Fabiano de Souza, Stéfanie Primon Muraro, Icaro Castro, Ana Paula Arévalo, Martina Crispo, Germán Galliussi, Sofía Russo, David Charbonnier, Florencia Rammauro, Mathías Jeldres, Catalina Alamón, Valentina Varela, Carlos Batthyany, Mariela Bollati-Fogolín, Pablo Oppezzo, Otto Pritsch, José Luiz Proença-Módena, Helder I. Nakaya, Emiliano Trias, Luis Barbeito, Ignacio Anegon, María Cristina Cuturi, Pedro Moraes-Vieira, Mercedes Segovia, Marcelo Hill

Publikováno v: Science Advances
Science Advances, 2022, 8 (38), pp.eabn6545. ⟨10.1126/sciadv.abn6545⟩

Severe COVID-19 is associated with hyperinflammation and weak T cell responses against SARS-CoV-2. However, the links between those processes remain partially characterized. Moreover, whether and how therapeutically manipulating T cells may benefit p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a852d837a96af8bf4932798ed6665d9
https://www.hal.inserm.fr/inserm-03872232/document

Sunitinib-Containing Carborane Pharmacophore with the Ability to Inhibit Tyrosine Kinases Receptors FLT3, KIT and PDGFR-β, Exhibits Powerful In Vivo Anti-Glioblastoma Activity

Autor: Marcos Couto, Moshe Gavish, Hugo Cerecetto, Carina Sánchez, Emiliano Trias, Clara Viñas, Luis Barbeito, Mariángeles Kovacs, Francesc Teixidor, Belén Dávila, Nidal Zeineh, Martín Gabay, Catalina Alamón, María Fernanda García

Publikováno v: Cancers
COLIBRI
Universidad de la República
instacron:Universidad de la República
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cancers, Vol 12, Iss 3423, p 3423 (2020)
Volume 12
Issue 11

Malignant gliomas are the most common malignant and aggressive primary brain tumors in adults, the prognosis being&mdash
especially for glioblastomas&mdash
extremely poor. There are no effective treatments yet. However, tyrosine kinase rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf34554d120fa9f188ae10d86d2f635
https://pubmed.ncbi.nlm.nih.gov/33218150