Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Cataldo Martucci"'
Autor:
Cataldo Martucci, Andrew Dennis Allen, Nadia Moretto, Valentina Bagnacani, Alessandro Fioni, Riccardo Patacchini, Maurizio Civelli, Gino Villetti, Fabrizio Facchinetti
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Inhibition of p38 mitogen-activated protein kinase (MAPKs) is a potential therapeutic approach for the treatment of acute and chronic pulmonary inflammatory conditions. Here, we report the in vitro and in vivo characterization of the anti-inflammator
Externí odkaz:
https://doaj.org/article/e024c104ed8c452b84fdb9c6bcc61046
Autor:
Elisabetta Armani, Carmelida Capaldi, Valentina Bagnacani, Francesca Saccani, Giancarlo Aquino, Paola Puccini, Fabrizio Facchinetti, Cataldo Martucci, Nadia Moretto, Gino Villetti, Riccardo Patacchini, Maurizio Civelli, Chris Hurley, Andrew Jennings, Lilian Alcaraz, Dawn Bloomfield, Michael Briggs, Stephen Daly, Terry Panchal, Vince Russell, Sharon Wicks, Harry Finch, Mary Fitzgerald, Craig Fox, Maurizio Delcanale
Publikováno v:
Journal of Medicinal Chemistry. 65:7170-7192
The identification of novel inhaled p38α/β mitogen-activated protein kinases (MAPK) (MAPK14/11) inhibitors suitable for the treatment of pulmonary inflammatory conditions has been described. A rational drug design approach started from the identifi
Autor:
Valentina Mileo, Anna Maria Capelli, Daniela Miglietta, P. Ronchi, Cataldo Martucci, Maurizio Civelli, Paola Maria Gallo, Matteo Biagetti, Silvia Capacchi, Serena Bertolini, A. Fioni, Gino Villetti
Publikováno v:
C60. ASTHMA: CELLULAR AND ANIMAL MODELS.
Autor:
Andrea Armirotti, Gian Filippo Ruda, Giampiero Colombano, Andrea Cavalli, Cataldo Martucci, Tiziano Bandiera, Rita Scarpelli, Rosalia Bertorelli, Giuliana Ottonello, Sine Mandrup Bertozzi, Federico Falchi, Claudio Fiorelli
Publikováno v:
Analytical Chemistry. 88:9510-9517
We propose a new QSRR model based on a Kernel-based partial least-squares method for predicting UPLC retention times in reversed phase mode. The model was built using a combination of classical (physicochemical and topological) and nonclassical (fing
Autor:
Andrew Allen, Veronica Puviani, Cataldo Martucci, Gino Villetti, Alice Pappani, Maurizio Civelli, Fabrizio Facchinetti, Chiara Carnini, Daniela Miglietta, Riccardo Patacchini
Publikováno v:
Airway Pharmacology and Treatment.
Inhibition of p38 MAPK is considered a possible new therapeutic approach for the treatment of COPD and severe asthma for which inhaled corticosteroids (ICS) have limited efficacy. We report here the effect of CHF6297, a potent and selective inhaled p
CHI-91040, a novel inhaled p38α inhibitor, counteracts lung inflammation induced by IL-1β in the rat
Autor:
Chiara Carnini, Maurizio Civelli, Giancarlo Aquino, Gino Villetti, Mary Fitzgerlad, Riccardo Patacchini, Valentina Bagnacani, Hanry Finch, Cataldo Martucci, Annalisa Murgo, Craig Fox
Publikováno v:
1.5 Diffuse Parenchymal Lung Disease.
INTRODUCTION: Intratracheal (i.t.) instillation of IL-1β in rodents has been reported to induce airway neutrophilia. Moreover, it has been shown that p38α MAPK is involved in IL-1β signalling in lung cells. In the present study CHI-91040, a new in
Publikováno v:
Anesthesia & Analgesia. 104:949-954
Background We examined the changes in cerebrospinal fluid (CSF) concentrations of prostaglandin E2 (PGE2) and tumor necrosis factor-alpha (TNF-alpha) after intraplantar administration of complete Freund's adjuvant (CFA) in rats. In addition, we inves
Autor:
Marilou Pannacci, Cataldo Martucci, Federica Colleoni, Paola Sacerdote, Valeria Lucini, Francesco Scaglione, Silvia Grosso
Publikováno v:
Brain, Behavior, and Immunity. 20:546-551
The effect of Panax ginseng C.A. Meyer G115 on inflammatory cytokine production and toll-like receptor 4 (TLR4) RNA expression was examined in mice during 4 weeks of swimming stress. Mice were assigned to four groups: (1) control (no exercise); (2) c
Autor:
Silvia Franchi, Paola Sacerdote, Hui Tian, Elisa Giannini, Cataldo Martucci, Pietro Melchiorri, Lucia Negri
Publikováno v:
British Journal of Pharmacology. 147:225-234
The small protein Bv8, isolated from the amphibian skin, belongs to a novel family of secreted proteins linked to several biological effects. We describe the expression of Bv8/prokineticins and their receptors in mouse macrophages, and characterize t
Publikováno v:
Brain Research. 1019:255-258
We previously described a rat model where the injection of formalin in the tail induced a facilitation of the hindpaw withdrawal reflexes (hyperalgesia). In the present work, after injecting formalin in the tail, we measured the levels of pro-nocicep