Role of brain c-Jun N-terminal kinase 2 in the control of the insulin receptor and its relationship with cognitive performance in a high-fat diet pre-clinical model

Autor: Busquets O, Eritja À, López BM, Ettcheto M, Manzine PR, Castro-Torres RD, Verdaguer E, Olloquequi J, Vazquez M, Auladell C, Folch J, Camins A

Publikováno v: JOURNAL OF NEUROCHEMISTRY
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu

Insulin resistance has negative consequences on the physiological functioning of the nervous system. The appearance of type 3 diabetes in the brain leads to the development of the sporadic form of Alzheimer's disease. The c-Jun N-terminal kinases (JN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::31c76e5f98ecd87c22408a11c2f60945
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15836

A mammalian-specific Alex3/Gα q protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival.

Autor: Izquierdo-Villalba I; Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Barcelona 08028, Spain., Mirra S; Department of Cell Biology, Physiology and Immunology, and Institute of Neurosciences, University of Barcelona, Barcelona 08028, Spain.; Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona 08028, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBER-CIBERNED), ISCIII, Madrid 28031, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Raras (CIBER-CIBERER), ISCIII, Madrid 28031, Spain.; Institut de Biomedicina- Institut de Recerca Sant Joan de Déu (IBUB-IRSJD), Universitat de Barcelona, Barcelona 08028, Spain., Manso Y; Department of Cell Biology, Physiology and Immunology, and Institute of Neurosciences, University of Barcelona, Barcelona 08028, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBER-CIBERNED), ISCIII, Madrid 28031, Spain., Parcerisas A; Department of Cell Biology, Physiology and Immunology, and Institute of Neurosciences, University of Barcelona, Barcelona 08028, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBER-CIBERNED), ISCIII, Madrid 28031, Spain.; Biosciences Department, Faculty of Sciences, Technology and Engineering, University of Vic, Central University of Catalonia (UVic-UCC); and Tissue Repair and Regeneration Laboratory (TR2Lab), Institut de Recerca i Innovació en Ciències de la Vida i de la Salut a la Catalunya Central (IRIS-CC), 08500 Vic, Spain., Rubio J; Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Barcelona 08028, Spain., Del Valle J; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBER-CIBERNED), ISCIII, Madrid 28031, Spain.; Department of Cell Biology, Physiology and Immunology, and Institute of Neurosciences, Universitat Autonoma de Barcelona, Bellaterra, Barcelona 08193, Spain., Gil-Bea FJ; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBER-CIBERNED), ISCIII, Madrid 28031, Spain.; Neurosciences Area, Biodonostia Health Research Institute, San Sebastián 20014, Spain., Ulloa F; Department of Cell Biology, Physiology and Immunology, and Institute of Neurosciences, University of Barcelona, Barcelona 08028, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBER-CIBERNED), ISCIII, Madrid 28031, Spain., Herrero-Lorenzo M; Department of Cell Biology, Physiology and Immunology, and Institute of Neurosciences, University of Barcelona, Barcelona 08028, Spain., Verdaguer E; Department of Cell Biology, Physiology and Immunology, and Institute of Neurosciences, University of Barcelona, Barcelona 08028, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBER-CIBERNED), ISCIII, Madrid 28031, Spain., Benincá C; Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Barcelona 08028, Spain., Castro-Torres RD; Department of Cell Biology, Physiology and Immunology, and Institute of Neurosciences, University of Barcelona, Barcelona 08028, Spain., Rebollo E; Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Barcelona 08028, Spain., Marfany G; Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona 08028, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Raras (CIBER-CIBERER), ISCIII, Madrid 28031, Spain.; Institut de Biomedicina- Institut de Recerca Sant Joan de Déu (IBUB-IRSJD), Universitat de Barcelona, Barcelona 08028, Spain., Auladell C; Department of Cell Biology, Physiology and Immunology, and Institute of Neurosciences, University of Barcelona, Barcelona 08028, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBER-CIBERNED), ISCIII, Madrid 28031, Spain., Navarro X; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBER-CIBERNED), ISCIII, Madrid 28031, Spain.; Department of Cell Biology, Physiology and Immunology, and Institute of Neurosciences, Universitat Autonoma de Barcelona, Bellaterra, Barcelona 08193, Spain., Enríquez JA; Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, Madrid 28029, Spain.; Centro de Investigación Biomédica en Red en Fragilidad y Envejecimiento Saludable (CIBER-CIBERFES), Madrid 28031, Spain., López de Munain A; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBER-CIBERNED), ISCIII, Madrid 28031, Spain.; Neurosciences Area, Biodonostia Health Research Institute, San Sebastián 20014, Spain.; Neurology Department, Donostia University Hospital, San Sebastián 20014, Spain., Soriano E; Department of Cell Biology, Physiology and Immunology, and Institute of Neurosciences, University of Barcelona, Barcelona 08028, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBER-CIBERNED), ISCIII, Madrid 28031, Spain., Aragay AM; Institut de Biologia Molecular de Barcelona (IBMB-CSIC), Barcelona 08028, Spain.

Publikováno v: Science signaling [Sci Signal] 2024 Feb 06; Vol. 17 (822), pp. eabq1007. Date of Electronic Publication: 2024 Feb 06.

c-Jun N-Terminal Kinases in Alzheimer's Disease: A Possible Target for the Modulation of the Earliest Alterations.

Autor: Busquets O; Department of Pharmacology, Toxicology and Therapeutic Chemistry; Pharmacy and Food Sciences Faculty, Universitat de Barcelona, Barcelona, Spain.; Department of Biochemistry and Biotechnology, Medicine and Health Sciences Faculty, Universitat Rovira i Virgili, Reus, Spain.; Centre for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.; Dominick P. Purpura Department of Neurosciences, Albert Einstein College of Medicine, New York City, NY, USA., Parcerisas A; Centre for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.; Department of Cell Biology, Physiology and Immunology, Biology Faculty, Universitat de Barcelona, Barcelona, Spain., Verdaguer E; Centre for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.; Department of Cell Biology, Physiology and Immunology, Biology Faculty, Universitat de Barcelona, Barcelona, Spain., Ettcheto M; Department of Pharmacology, Toxicology and Therapeutic Chemistry; Pharmacy and Food Sciences Faculty, Universitat de Barcelona, Barcelona, Spain.; Centre for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain., Camins A; Department of Pharmacology, Toxicology and Therapeutic Chemistry; Pharmacy and Food Sciences Faculty, Universitat de Barcelona, Barcelona, Spain.; Centre for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain., Beas-Zarate C; Department of Cell and Molecular Biology, Laboratory of Neural Regeneration, C.U.C.B.A., Universidad de Guadalajara, Jalisco, Mexico., Castro-Torres RD; Department of Cell and Molecular Biology, Laboratory of Biology of Neurotransmission, C.U.C.B.A., Universidad de Guadalajara, Jalisco, Mexico., Auladell C; Centre for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.; Institut de Neurociències, Universitat de Barcelona, Barcelona, Spain.; Department of Cell Biology, Physiology and Immunology, Biology Faculty, Universitat de Barcelona, Barcelona, Spain.

Publikováno v: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2021; Vol. 82 (s1), pp. S127-S139.

Involvement of JNK1 in Neuronal Polarization During Brain Development.

Autor: Castro-Torres RD; Department of Cell and Molecular Biology, Laboratory of Biology of Neurotransmission, C.U.C.B.A., Universidad de Guadalajara, 45200 Jalisco, Mexico., Busquets O; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacy and Food Sciences Faculty, Universitat de Barcelona, 08028 Barcelona, Spain.; Department of Biochemistry and Biotechnology, Medicine and Health Sciences Faculty, Universitat Rovira i Virgil, 43201 Reus, Spain.; Centre for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Institut de Neurociències, Universitat de Barcelona, 08035 Barcelona, Spain., Parcerisas A; Centre for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Institut de Neurociències, Universitat de Barcelona, 08035 Barcelona, Spain.; Department of Cell Biology, Physiology and Immunology, Biology Faculty, Universitat de Barcelona, 08028 Barcelona, Spain., Verdaguer E; Centre for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Institut de Neurociències, Universitat de Barcelona, 08035 Barcelona, Spain.; Department of Cell Biology, Physiology and Immunology, Biology Faculty, Universitat de Barcelona, 08028 Barcelona, Spain., Olloquequi J; Laboratory of Cellular and Molecular Pathology, Biomedical Sciences Institute, Health Sciences Faculty, Universidad Autónoma de Chile, 3460000 Talca, Chile., Ettcheto M; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacy and Food Sciences Faculty, Universitat de Barcelona, 08028 Barcelona, Spain.; Department of Biochemistry and Biotechnology, Medicine and Health Sciences Faculty, Universitat Rovira i Virgil, 43201 Reus, Spain.; Centre for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Institut de Neurociències, Universitat de Barcelona, 08035 Barcelona, Spain., Beas-Zarate C; Department of Cell and Molecular Biology, Laboratory of Neural Regeneration, C.U.C.B.A., Universidad de Guadalajara, 44340 Jalisco, Mexico., Folch J; Department of Biochemistry and Biotechnology, Medicine and Health Sciences Faculty, Universitat Rovira i Virgil, 43201 Reus, Spain.; Centre for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain., Camins A; Department of Pharmacology, Toxicology and Therapeutic Chemistry, Pharmacy and Food Sciences Faculty, Universitat de Barcelona, 08028 Barcelona, Spain.; Department of Biochemistry and Biotechnology, Medicine and Health Sciences Faculty, Universitat Rovira i Virgil, 43201 Reus, Spain.; Centre for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Institut de Neurociències, Universitat de Barcelona, 08035 Barcelona, Spain., Auladell C; Centre for Biomedical Research of Neurodegenerative Diseases (CIBERNED), Instituto de Salud Carlos III, 28029 Madrid, Spain.; Institut de Neurociències, Universitat de Barcelona, 08035 Barcelona, Spain.; Department of Cell Biology, Physiology and Immunology, Biology Faculty, Universitat de Barcelona, 08028 Barcelona, Spain.

Publikováno v: Cells [Cells] 2020 Aug 13; Vol. 9 (8). Date of Electronic Publication: 2020 Aug 13.

Epigallocatechin-3-Gallate (EGCG) Improves Cognitive Deficits Aggravated by an Obesogenic Diet Through Modulation of Unfolded Protein Response in APPswe/PS1dE9 Mice.

Autor: Ettcheto M; Departament of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, University of Barcelona, Barcelona, Spain.; Department of Biochemistry and Biotechnology, Faculty of Medicine and Life Science, University Rovira i Virgili, Reus, Spain.; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Madrid, Spain.; Institute of Neuroscience, University of Barcelona, Barcelona, Spain., Cano A; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Madrid, Spain.; Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Barcelona, Spain.; Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Science, University of Barcelona, Barcelona, Spain., Manzine PR; Department of Gerontology, Federal University of São Carlos (UFSCar), São Carlos, 13565-905, Brazil., Busquets O; Departament of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, University of Barcelona, Barcelona, Spain.; Department of Biochemistry and Biotechnology, Faculty of Medicine and Life Science, University Rovira i Virgili, Reus, Spain.; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Madrid, Spain.; Institute of Neuroscience, University of Barcelona, Barcelona, Spain., Verdaguer E; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Madrid, Spain.; Institute of Neuroscience, University of Barcelona, Barcelona, Spain.; Department of Cellular Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Barcelona, Spain., Castro-Torres RD; Departament of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, University of Barcelona, Barcelona, Spain.; Department of Biochemistry and Biotechnology, Faculty of Medicine and Life Science, University Rovira i Virgili, Reus, Spain.; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Madrid, Spain.; Institute of Neuroscience, University of Barcelona, Barcelona, Spain.; Department of Cellular Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Barcelona, Spain.; Department of Cellular and Molecular Biology, Neuroscience Division, C.U.C.B.A., University of Guadalajara, Sierra Mojada, Col. Independencia, Guadalajara, Jalisco, México., García ML; Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Barcelona, Spain.; Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Science, University of Barcelona, Barcelona, Spain., Beas-Zarate C; Department of Cellular and Molecular Biology, Neuroscience Division, C.U.C.B.A., University of Guadalajara, Sierra Mojada, Col. Independencia, Guadalajara, Jalisco, México., Olloquequi J; Laboratory of Cellular and Molecular Pathology, Facultad de Ciencias de la Salud, Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Talca, Chile., Auladell C; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Madrid, Spain.; Institute of Neuroscience, University of Barcelona, Barcelona, Spain.; Department of Cellular Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Barcelona, Spain., Folch J; Department of Biochemistry and Biotechnology, Faculty of Medicine and Life Science, University Rovira i Virgili, Reus, Spain.; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Madrid, Spain., Camins A; Departament of Pharmacology, Toxicology and Therapeutic Chemistry, Faculty of Pharmacy and Food Science, University of Barcelona, Barcelona, Spain. camins@ub.edu.; Biomedical Research Networking Centre in Neurodegenerative Diseases (CIBERNED), Madrid, Spain. camins@ub.edu.; Institute of Neuroscience, University of Barcelona, Barcelona, Spain. camins@ub.edu.; Laboratory of Cellular and Molecular Pathology, Facultad de Ciencias de la Salud, Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Talca, Chile. camins@ub.edu.; Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Av. Joan XXIII 27/31, E-08028, Barcelona, Spain. camins@ub.edu.

Publikováno v: Molecular neurobiology [Mol Neurobiol] 2020 Apr; Vol. 57 (4), pp. 1814-1827. Date of Electronic Publication: 2019 Dec 14.