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Prostate Cancer Drug Therapy

Publikováno v: American Journal of Men's Health. 16(4)

Due to the COVID-19 pandemic, major congresses and many teaching opportunities as well as the usual visits from medical advisors of pharmaceutical firms have been postponed and canceled. The major trials of prostate cancer in the last 5 years in each

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od________83::3d0eee68fe9092d6325bc77a97a8ece3
https://doi.org/10.1177/15579883221115593

Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence

Autor: Linder, Simon, Hoogstraat, Marlous, Stelloo, Suzan, Eickhoff, Nils, Schuurman, Karianne, de Barros, Hilda, Alkemade, Maartje, Bekers, Elise M., Severson, Tesa M., Sanders, Joyce, Huang, Chia Chi Flora, Morova, Tunc, Altintas, Umut Berkay, Hoekman, Liesbeth, Kim, Yongsoo, Baca, Sylvan C., Sjöström, Martin, Zaalberg, Anniek, Hintzen, Dorine C., de Jong, Jeroen, Kluin, Roelof J.C., de Rink, Iris, Giambartolomei, Claudia, Seo, Ji Heui, Pasaniuc, Bogdan, Altelaar, Maarten, Medema, René H., Feng, Felix Y., Zoubeidi, Amina, Freedman, Matthew L., Wessels, Lodewyk F.A., Butler, Lisa M., Lack, Nathan A., van der Poel, Henk, Bergman, Andries M., Zwart, Wilbert, Afd Biomol.Mass Spect. and Proteomics, Biomolecular Mass Spectrometry and Proteomics

Publikováno v: Cancer Discovery, 12(9), 2074-2097. American Association for Cancer Research Inc.
Cancer Discovery, 12(9), 2074. American Association for Cancer Research Inc.
Linder, S, Hoogstraat, M, Stelloo, S, Eickhoff, N, Schuurman, K, de Barros, H, Alkemade, M, Bekers, E M, Severson, T M, Sanders, J, Huang, C-C F, Morova, T, Altintas, U B, Hoekman, L, Kim, Y, Baca, S C, Sjöström, M, Zaalberg, A, Hintzen, D C, de Jong, J, Kluin, R J C, de Rink, I, Giambartolomei, C, Seo, J-H, Pasaniuc, B, Altelaar, M, Medema, R H, Feng, F Y, Zoubeidi, A, Freedman, M L, Wessels, L F A, Butler, L M, Lack, N A, van der Poel, H, Bergman, A M & Zwart, W 2022, ' Drug-Induced Epigenomic Plasticity Reprograms Circadian Rhythm Regulation to Drive Prostate Cancer toward Androgen Independence ', Cancer discovery, vol. 12, no. 9, pp. 2074-2097 . https://doi.org/10.1158/2159-8290.CD-21-0576
Cancer Discov
Cancer discovery, 12(9)
Cancer discovery, vol 12, iss 9
Cancer discovery, 12(9), 2074-2097. American Association for Cancer Research Inc.

In prostate cancer, androgen receptor (AR)–targeting agents are very effective in various disease stages. However, therapy resistance inevitably occurs, and little is known about how tumor cells adapt to bypass AR suppression. Here, we performed in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039c32e9b5e18899785f8d02a47ca186
https://doi.org/10.1158/2159-8290.cd-21-0576

Exercise prescription dose for castrate-resistant prostate cancer patients: a phase I prescription dose escalation trial

Autor: Piet Ost, Jörgen Van Bauwel, Valérie Fonteyne, Renée Bultijnck, Karel Decaestecker, Noëmi Borrey, Elke Rammant, Adelheid Steyaert, Benedicte Deforche, Nicolaas Lumen, Maarten Lievens

Publikováno v: World Journal of Urology. 39:357-364

PURPOSE: To determine the start exercise prescription dose in metastatic castrate-resistant prostate cancer (mCRPC) patients receiving second-line hormone treatment and recommended phase II exercise prescription. METHODS: Patients were enrolled in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6deb95015c15c85009b3c07f92c5cfd
https://doi.org/10.1007/s00345-020-03098-y

Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer

Autor: Stephane OUDARD, David Olmos Hidalgo, María J. Ribal, Tomasz Drewa, ARANZAZU GONZALEZ-DEL-ALBA, Marcin Słojewski, Susan Ellard, Louis Lacombe, PABLO MAROTO REY, Javier Angulo, Adel Izmailov, Gwenaelle Gravis, Lisa Horvath, Boris Hadaschik, Ernesto Sanchez Sanchez, Florence Joly, Emmanuelle Bompas, Anders Kjellman, Hakim MAHAMMEDI, Arnauld VILLERS, Jose Luis Perez-Gracia, Carlos Ferrer Albiach

Publikováno v: The New England Journal of Medicine, 378, 15, pp. 1408-1418
Poulsen, M H & SPARTAN Investigators 2018, ' Apalutamide treatment and metastasis-free survival in prostate cancer ', New England Journal of Medicine, vol. 378, no. 15, pp. 1408-1418 . https://doi.org/10.1056/NEJMoa1715546
The New England Journal of Medicine, 378, 1408-1418

Contains fulltext : 193640.pdf (Publisher’s version ) (Open Access) BACKGROUND: Apalutamide, a competitive inhibitor of the androgen receptor, is under development for the treatment of prostate cancer. We evaluated the efficacy of apalutamide in me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea90d31f6d3252422ae43378828f8e7c
https://doi.org/10.1056/nejmoa1715546