A Novel UPLC-MS Metabolomic Analysis-Based Strategy to Monitor the Course and Extent of iPSC Differentiation to Hepatocytes

Autor: Moreno-Torres M, Kumar M, García-Llorens G, Quintás G, Tricot T, Boon R, Tolosa L, Toprakhisar B, Chesnais F, Verfaillie C, Castell JV

Publikováno v: JOURNAL OF PROTEOME RESEARCH
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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Typical protocols to differentiate induced pluripotent stem cells (iPSCs) from hepatocyte-like cells (HLCs) imply complex strategies that include transfection with key hepatic transcription factors and the addition to culture media of nutrients, grow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::9a76b4ad50d7525022c71a4ee84fb918
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=15446

Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways

Autor: Petrov PD, Soluyanova P, Sánchez-Campos S, Castell JV, Jover R

Publikováno v: FOOD AND CHEMICAL TOXICOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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Treatment of ß-lactamase positive bacterial infections with a combination of amoxicillin (AMOX) and clavulanic acid (CLAV) causes idiosyncratic drug-induced liver injury (iDILI) in a relevant number of patients, often with features of intrahepatic c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::0330895a7c055050d2a6e3be9d0b8b06
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=15111

Toward Rapid Screening of Liver Grafts at the Operating Room Using Mid-infrared Spectroscopy

Autor: Pérez-Guaita D, Moreno-Torres M, Jover R, Pareja E, Lendl B, Kuligowski J, Quintás G, Castell JV

Publikováno v: ANALYTICAL CHEMISTRY
r-FISABIO. Repositorio Institucional de Producción Científica
instname
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)

The estimation of steatosis in a liver graft is mandatory prior to liver transplantation, as the risk of graft failure increases with the level of infiltrated fat. However, the assessment of liver steatosis before transplantation is typically based o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6b64c357ff53ec7719e26f5692308332
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=8114

A Network Involving Gut Microbiota, Circulating Bile Acids, and Hepatic Metabolism Genes That Protects Against Non-Alcoholic Fatty Liver Disease

Autor: Petrov PD, García-Mediavilla MV, Guzmán C, Porras D, Nistal E, Martínez-Flórez S, Castell JV, González-Gallego J, Sánchez-Campos S, Jover R

Publikováno v: MOLECULAR NUTRITION & FOOD RESEARCH
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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Gut microbiota contributes to non-alcoholic fatty liver disease (NAFLD) pathogenesis by multiple mechanisms not yet completely understood. Novel differential features between germ-free mice (GFm) transplanted with protective or non-protective cecal m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::18814ac1935172dedbd08837a717672e
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=11094

Direct conversion of human fibroblast to hepatocytes using a single inducible polycistronic vector

Autor: Ballester M, Bolonio M, Santamaria R, Castell JV, Ribes-Koninckx C, Bort R

Publikováno v: STEM CELL RESEARCH & THERAPY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
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Human fibroblasts can be reprogrammed into induced hepatocyte-like cells through the expression of a set of transcription factors. Although the generation of induced hepatocyte-like cells by HNF4A, HNF1A, and FOXA3 expression has proven to be a robus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=RECOLECTA___::37016c3c8cc4dc672d3c0a950490ccc6
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=11355