Enzyme controlled glucose auto-delivery for high cell density cultivations in microplates and shake flasks

Autor: Casteleijn Marco G, Wilmanowski Robert, Vasala Antti, Šiurkus Juozas, Panula-Perälä Johanna, Neubauer Peter

Publikováno v: Microbial Cell Factories, Vol 7, Iss 1, p 31 (2008)

Abstract Background Here we describe a novel cultivation method, called EnBase™, or enzyme-based-substrate-delivery, for the growth of microorganisms in millilitre and sub-millilitre scale which yields 5 to 20 times higher cell densities compared t

Externí odkaz: https://doaj.org/article/18558a5fb2b84e8d9dd4161e9c27d618

Spin coated chitin films for biosensors and its analysis are dependent on chitin-surface interactions

Autor: Casteleijn, Marco G., Richardson, Dominique, Parkkila, Petteri, Granqvist, Niko, Urtti, Arto, Viitala, Tapani

Publikováno v: In Colloids and Surfaces A: Physicochemical and Engineering Aspects 20 February 2018 539:261-272

High-temperature cultivation and 5′ mRNA optimization are key factors for the efficient overexpression of thermostable Deinococcus geothermalis purine nucleoside phosphorylase in Escherichia coli

Autor: Szeker, Kathleen, Niemitalo, Olli, Casteleijn, Marco G., Juffer, André H., Neubauer, Peter

Publikováno v: In Journal of Biotechnology 2011 156(4):268-274

Characterization, stability, and in vivo efficacy studies of recombinant human CNTF and its permeation into the neural retina in ex vivo organotypic retinal explant culture models

Autor: Itkonen, Jaakko, Annala, Ada, Tavakoli, Shirin, Arango-Gonzalez, Blanca, Ueffing, Marius, Toropainen, Elisa, Ruponen, Marika, Casteleijn, Marco G., Urtti, Arto

Publikováno v: Itkonen, J, Annala, A, Tavakoli, S, Arango-Gonzalez, B, Ueffing, M, Toropainen, E, Ruponen, M, Casteleijn, M G & Urtti, A 2020, ' Characterization, stability, and in vivo efficacy studies of recombinant human CNTF and its permeation into the neural retina in ex vivo organotypic retinal explant culture models ', Pharmaceutics, vol. 12, no. 7, 611, pp. 1-31 . https://doi.org/10.3390/pharmaceutics12070611
Pharmaceutics, Vol 12, Iss 611, p 611 (2020)
Pharmaceutics
Volume 12
Issue 7

Ciliary neurotrophic factor (CNTF) is one of the most studied neuroprotective agents with acknowledged potential in treating diseases of the posterior eye segment. Although its efficacy and mechanisms of action in the retina have been studied extensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e7a6b977ccd07ce2ca5b5e2478181f64
https://cris.vtt.fi/en/publications/b49c5c47-67a4-48f6-97e8-b95e21c17279

Pharmacokinetic aspects of retinal drug delivery

Autor: del Amo, Eva M., Rimpelä, Anna-Kaisa Irmeli, Heikkinen, Emma, Kari, Otto K., Ramsay, Eva, Lajunen, Tatu, Schmitt, Mechthild, Pelkonen, Laura, Bhattacharya, Madhushree, Richardson, Dominique, Subrizi, Astrid, Turunen, Tiina, Reinisalo, Mika, Itkonen, Jaakko, Toropainen, Elisa, Casteleijn, Marco G., Kidron, Heidi, Antopolsky, Maxim, Vellonen, Kati-Sisko, Ruponen, Marika, Urtti, Arto

Drug delivery to the posterior eye segment is an important challenge in ophthalmology, because many diseases affect the retina and choroid leading to impaired vision or blindness. Currently, intravitreal injections are the method of choice to adminis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1593::55b0dc4cc3b6a127c8d6de8f0f502ecb
http://hdl.handle.net/10138/218281