Loss of adipose ATF3 promotes adipose tissue lipolysis and the development of MASH.

Autor: Hu S; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.; Department of Internal Medicine, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, 85004, USA., Cassim Bawa FN; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA., Zhu Y; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.; School of Biomedical Sciences, Kent State University Kent, Kent, OH, 44240, USA., Pan X; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA., Wang H; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.; School of Biomedical Sciences, Kent State University Kent, Kent, OH, 44240, USA., Gopoju R; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.; Department of Internal Medicine, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, 85004, USA., Xu Y; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA.; Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Pathology of School of Basic Medical Sciences, Fudan University, Shanghai, China., Zhang Y; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, 44272, USA. yzhang8@arizona.edu.; Department of Internal Medicine, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, 85004, USA. yzhang8@arizona.edu.

Publikováno v: Communications biology [Commun Biol] 2024 Oct 10; Vol. 7 (1), pp. 1300. Date of Electronic Publication: 2024 Oct 10.

Nuclear receptor corepressors non-canonically drive glucocorticoid receptor-dependent activation of hepatic gluconeogenesis.

Autor: Hauck AK; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Mehmood R; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Carpenter BJ; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Frankfurter MT; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Tackenberg MC; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Inoue SI; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Krieg MK; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Cassim Bawa FN; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Midha MK; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Zundell DM; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Batmanov K; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lazar MA; Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. lazar@pennmedicine.upenn.edu.; Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. lazar@pennmedicine.upenn.edu.

Publikováno v: Nature metabolism [Nat Metab] 2024 May; Vol. 6 (5), pp. 825-836. Date of Electronic Publication: 2024 Apr 15.

Hepatocyte Sirtuin 6 Protects against Atherosclerosis and Steatohepatitis by Regulating Lipid Homeostasis.

Autor: Zhu Y; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA.; School of Biomedical Sciences, Kent State University, Kent, OH 44240, USA., Hu S; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA., Pan X; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA., Gopoju R; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA., Cassim Bawa FN; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA., Yin L; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA., Xu Y; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA., Zhang Y; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272, USA.

Publikováno v: Cells [Cells] 2023 Aug 05; Vol. 12 (15). Date of Electronic Publication: 2023 Aug 05.

Hepatic retinoic acid receptor alpha mediates all-trans retinoic acid's effect on diet-induced hepatosteatosis.

Autor: Cassim Bawa FN; School of Biomedical Sciences, Kent State University Kent, Kent, Ohio, USA.; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio, USA., Xu Y; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio, USA.; Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Pathology of School of Basic Medical Sciences, Fudan University, Shanghai, China., Gopoju R; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio, USA., Plonski NM; School of Biomedical Sciences, Kent State University Kent, Kent, Ohio, USA., Shiyab A; School of Biomedical Sciences, Kent State University Kent, Kent, Ohio, USA.; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio, USA., Hu S; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio, USA., Chen S; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio, USA., Zhu Y; School of Biomedical Sciences, Kent State University Kent, Kent, Ohio, USA.; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio, USA., Jadhav K; School of Biomedical Sciences, Kent State University Kent, Kent, Ohio, USA.; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio, USA., Kasumov T; Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, Ohio, USA., Zhang Y; Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, Ohio, USA.

Publikováno v: Hepatology communications [Hepatol Commun] 2022 Oct; Vol. 6 (10), pp. 2665-2675. Date of Electronic Publication: 2022 Jul 19.