Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Cassie L. Rayner"'
Autor:
Ling Zhu, Rui Zhang, Weiyong Shen, Victoria Pye, Yoshio Hirabayashi, Pankaj Seth, Ashish Easow Mathai, Michelle Yam, Shigeki Furuya, So Ra Lee, James B. Hurley, Jianhai Du, Mark C Gillies, Cassie L. Rayner, Nigel L. Barnett
Publikováno v:
Glia. 69:1966-1986
The importance of Müller glia for retinal homeostasis suggests that they may have vulnerabilities that lead to retinal disease. Here, we studied the effect of selectively knocking down key metabolic genes in Müller glia on photoreceptor health. Imm
Autor:
Shuko Suzuki, Smith Tai Mountford, Damien G. Harkin, Nestor Sabat, Cassie L. Rayner, Traian V. Chirila
Publikováno v:
Ophthalmic Plastic & Reconstructive Surgery. 35:600-603
Purpose: A follow-up experimental study on the exposure of animal tarsal plate to ultraviolet-A radiation aimed at establishing an optimum range for safe irradiation conditions. Methods: Sheep tarsus specimens were excised postmortem and then subject
Publikováno v:
Advances in Tissue Engineering & Regenerative Medicine: Open Access. 5
Publikováno v:
Neurochemistry International. 92:1-12
Nitroxides have been exploited as profluorescent probes for the detection of oxidative stress. In addition, they deliver potent antioxidant action and attenuate reactive oxygen species (ROS) in various models of oxidative stress, with these results a
Publikováno v:
Experimental Eye Research. 129:48-56
Changes to the redox status of biological systems have been implicated in the pathogenesis of a wide variety of disorders including cancer, Ischemia-reperfusion (I/R) injury and neurodegeneration. In times of metabolic stress e.g. ischaemia/reperfusi
Autor:
Jason Tong, Nigel L. Barnett, Kathryn E. Fairfull-Smith, Steven E. Bottle, David A. Wink, Cassie L. Rayner, Terry W. Moody, Robert T. Jensen, Lisa A. Ridnour, Komba Thomas
Publikováno v:
Eur J Med Chem
Dual-acting hybrid anti-oxidant/anti-inflammatory agents were developed employing the principle of pharmacophore hybridization. Hybrid agents were synthesized by combining stable anti-oxidant nitroxides with conventional non-steroidal anti-inflammato
Publikováno v:
Clinical & Experimental Ophthalmology. 41:119-133
Purpose: To evaluate the utility of a novel profluorescent nitroxide (PFN) probe that selectively detects superoxide radicals in live cells, as a reporter of retinal oxidative status in models of retinal metabolic challenge.Method: (i) Cultured RGC-5
Publikováno v:
Experimental Eye Research. 107:11-20
The role of individual ocular tissues in mediating changes to the sclera during myopia development is unclear. The aim of this study was to examine the effects of retina, RPE and choroidal tissues from myopic and hyperopic chick eyes on the DNA and g
Publikováno v:
Ophthalmicphysiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists). 33(3)
Purpose: In animal models hemi-field deprivation results in localised, graded vitreous chamber elongation and presumably deprivation induced localised changes in retinal processing. The aim of this research was to determine if there are variations in
Publikováno v:
Experimental eye research. 110
Intravitreal injections of GABA antagonists, dopamine agonists and brief periods of normal vision have been shown separately to inhibit form-deprivation myopia (FDM). Our study had three aims: (i) establish whether GABAergic agents modify the myopia