Výsledky vyhledávání - "Cassie L. Keener"

Acetaminophen-induced liver injury is attenuated in male glutamate-cysteine ligase transgenic mice

Autor: Warren C. Ladiges, Michael J. Dabrowski, Nelson Fausto, Dianne Botta, Terrance J. Kavanagh, Sengkeo L. Srinouanprachanh, Charles L. White, Robert H. Pierce, Shengli Shi, Federico M. Farin, Carol B. Ware, Cassie L. Keener

Publikováno v: The Journal of biological chemistry. 281(39)

Acetaminophen overdose is a leading cause of drug-related acute liver failure in the United States. Glutathione, a tripeptide antioxidant protects cells against oxidative damage from reactive oxygen species and plays a crucial role in the detoxificat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f864b46c8f0f73947d05df5d4f490e6e
https://pubmed.ncbi.nlm.nih.gov/16840778

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Variants in the Glutamate-Cysteine-Ligase Gene Are Associated with Cystic Fibrosis Lung Disease

Autor: Mark R. Tonelli, Peter D. Paré, Edward F. McKone, Jing Shao, Cynthia Shephard, Moira L. Aitken, Cassie L. Keener, Andrew J. Sandford, Terrance J. Kavanagh, Federico M. Farin, Daisy D. Frangolias

Chronic progressive lung disease is the most serious complication of cystic fibrosis (CF). Glutathione plays an important role in the protection of the CF lung against oxidant-induced lung injury.We hypothesized that a polymorphism in a novel candida

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7d472b423d63afee3d59c45c558cdd
https://europepmc.org/articles/PMC2648118/

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Tissue specific changes in the expression of glutamate-cysteine ligase mRNAs in mice exposed to methylmercury

Autor: Dolores Diaz, Cecile M. Krejsa, Cassie L. Keener, Federico M. Farin, Charles L. White, Terrance J. Kavanagh

Publikováno v: Toxicology letters. 122(2)

Glutamate-cysteine ligase (GLCL), the rate-limiting enzyme in glutathione (GSH) synthesis is composed of two subunits, a catalytic (GLCLc) and a regulatory subunit (GLCLr). These two subunits are known to be differentially regulated in vitro, in diff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f97557cce38750ae304de7219250bf
https://pubmed.ncbi.nlm.nih.gov/11439218

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Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism

Autor: Cornelia M. Ulrich, Mark M. Schubert, Sue Li, Hao Liu, Jeannette Bigler, John L. Wagner, Yutaka Yasui, Federico M. Farin, John D. Potter, Kiley S. Ariail, Cassie L. Keener, Rainer Storb

Publikováno v: Blood. 98(1)

This study investigated whether a polymorphism in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene (C677T) modifies responses to methotrexate (MTX) in patients undergoing bone marrow transplantation. About 10% to 12% of the population carry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c6ac01ca771cafdbbea180c2c185d0
https://pubmed.ncbi.nlm.nih.gov/11592264

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