Identification of the human DPR core promoter element using machine learning

Autor: Cassidy Yunjing Huang, James T. Kadonaga, Long Vo Ngoc, California Jack Cassidy, Claudia Medrano

Publikováno v: Nature, vol 585, iss 7825

The RNA polymerase II (Pol II) core promoter is the strategic site of convergence of the signals that lead to the initiation of DNA transcription1-5, but the downstream core promoter in humans has been difficult to understand1-3. Here we analyse the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebdcb614414e46bcb4c7223bb0e58be
https://escholarship.org/uc/item/1wj60543

The human initiator is a distinct and abundant element that is precisely positioned in focused core promoters

Autor: Sascha H. Duttke, California Jack Cassidy, Long Vo Ngoc, James T. Kadonaga, Cassidy Yunjing Huang

Publikováno v: Ngoc, LV; Cassidy, CJ; Huang, CY; Duttke, SHC; & Kadonaga, JT. (2017). The human initiator is a distinct and abundant element that is precisely positioned in focused core promoters. GENES & DEVELOPMENT, 31(1), 6-11. doi: 10.1101/gad.293837.116. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/84b5j6sd
Genes & development, vol 31, iss 1

DNA sequence signals in the core promoter, such as the initiator (Inr), direct transcription initiation by RNA polymerase II. Here we show that the human Inr has the consensus of BBCA+1BW at focused promoters in which transcription initiates at a sin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf87bee23f47db76c241b563624d527
http://www.escholarship.org/uc/item/84b5j6sd

The human initiator is a distinct and abundant element that is precisely positioned in focused core promoters.

Autor: Long Vo ngoc¹, Cassidy, California Jack¹, Cassidy Yunjing Huang¹, Duttke, Sascha H. C.¹, Kadonaga, James T.¹ jkadonaga@ucsd.edu

Publikováno v: Genes & Development. Jan2017, Vol. 31 Issue 1, p6-11. 6p.