Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Cassidy Whitefield"'
Publikováno v:
RSC Chemical Biology. 3:341-349
Heparanase is the only human enzyme known to hydrolyse heparin sulfate and is involved in many important physiological processes. However, it is also unregulated in many disease states, such as cancer, diabetes and Covid-19. It is thus an important d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4b059d313e90660b75c70f6f0b3ca5
https://doi.org/10.1039/d1cb00239b
https://doi.org/10.1039/d1cb00239b
Autor:
Cassidy Whitefield, Yen Vo, Brett D Schwartz, Caryn Hepburn, F. Hafna Ahmed, Hideki Onagi, Martin G. Banwell, Keats Nelms, Lara R. Malins, Colin J Jackson
Heparanase (HPSE) is the only mammalian endo-β-glucuronidase known to catalyse the degradation of heparan sulfate. Dysfunction of HPSE activity has been linked to several disease states, resulting in HPSE becoming the target of numerous therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de600e29d867970f528c2f6ba57ec3cb
https://doi.org/10.1101/2023.01.05.522817
https://doi.org/10.1101/2023.01.05.522817
Autor:
Xiaobai Zhang, Cassidy Whitefield, Laura Shuttleworth, Kasuni B Ekanayake, Richard Morewood, Gottfried Otting, Colin J. Jackson, Josemon George, Christoph Nitsche, Mithun C. Mahawaththa, Vishnu M. Sasi, Sven Ullrich
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
Specific anti-coronaviral drugs complementing available vaccines are urgently needed to fight the COVID-19 pandemic. Given its high conservation across the betacoronavirus genus and dissimilarity to human proteases, the SARS-C
Specific anti-coronaviral drugs complementing available vaccines are urgently needed to fight the COVID-19 pandemic. Given its high conservation across the betacoronavirus genus and dissimilarity to human proteases, the SARS-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ebe2685cd2a0204269d9eacb7bbeac7
https://doi.org/10.1016/j.bmcl.2021.128333
https://doi.org/10.1016/j.bmcl.2021.128333