siRNA targeting Schlemm's canal endothelial tight junctions enhances outflow facility and reduces IOP in a steroid-induced OHT rodent model.

Autor: Cassidy PS; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Kelly RA; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Reina-Torres E; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.; Department of Bioengineering, Imperial College London, London, UK., Sherwood JM; Department of Bioengineering, Imperial College London, London, UK., Humphries MM; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Kiang AS; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Farrar GJ; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., O'Brien C; Department of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland., Campbell M; Neurovascular Research Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., Stamer WD; Department of Ophthalmology, Duke University, Durham, NC, USA., Overby DR; Department of Bioengineering, Imperial College London, London, UK., Humphries P; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland., O'Callaghan J; Ocular Genetics Unit, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.; Neurovascular Research Laboratory, Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland.

Publikováno v: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2020 Oct 31; Vol. 20, pp. 86-94. Date of Electronic Publication: 2020 Oct 31 (Print Publication: 2021).

Open-angle glaucoma: therapeutically targeting the extracellular matrix of the conventional outflow pathway.

Autor: O'Callaghan J; a Ocular Genetics Unit, Smurfit Institute of Genetics , University of Dublin, Trinity College , Dublin , Ireland., Cassidy PS; a Ocular Genetics Unit, Smurfit Institute of Genetics , University of Dublin, Trinity College , Dublin , Ireland., Humphries P; a Ocular Genetics Unit, Smurfit Institute of Genetics , University of Dublin, Trinity College , Dublin , Ireland.

Publikováno v: Expert opinion on therapeutic targets [Expert Opin Ther Targets] 2017 Nov; Vol. 21 (11), pp. 1037-1050. Date of Electronic Publication: 2017 Oct 05.

Enhancement of Outflow Facility in the Murine Eye by Targeting Selected Tight-Junctions of Schlemm's Canal Endothelia.

Autor: Tam LC; Neurovascular Genetics, Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland., Reina-Torres E; Neurovascular Genetics, Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland.; Department of Bioengineering, Imperial College London, London, UK., Sherwood JM; Department of Bioengineering, Imperial College London, London, UK., Cassidy PS; Neurovascular Genetics, Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland., Crosbie DE; Neurovascular Genetics, Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland., Lütjen-Drecoll E; Department of Anatomy, University of Erlangen-Nürnberg, Erlangen, Germany., Flügel-Koch C; Department of Anatomy, University of Erlangen-Nürnberg, Erlangen, Germany., Perkumas K; Department of Ophthalmology, Duke University, Durham, NC, USA., Humphries MM; Neurovascular Genetics, Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland., Kiang AS; Neurovascular Genetics, Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland., O'Callaghan J; Neurovascular Genetics, Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland., Callanan JJ; Ross University School of Veterinary Medicine, P. O. Box 334, Basseterre, St. Kitts, West Indies., Read AT; Department of Ophthalmology and Vision Sciences, University of Toronto, Canada., Ethier CR; Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, USA., O'Brien C; Ophthalmology, Mater Hospital, UCD School of Medicine, Dublin, Ireland., Lawrence M; RxGen, Hamden, CT, USA., Campbell M; Neurovascular Genetics, Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland., Stamer WD; Department of Ophthalmology, Duke University, Durham, NC, USA., Overby DR; Department of Bioengineering, Imperial College London, London, UK., Humphries P; Neurovascular Genetics, Smurfit Institute of Genetics, Trinity College, University of Dublin, Dublin 2, Ireland.

Publikováno v: Scientific reports [Sci Rep] 2017 Jan 16; Vol. 7, pp. 40717. Date of Electronic Publication: 2017 Jan 16.

Three Na+, K+-ATPase forms in rat heart as revealed by K+/ouabain antagonism.

Autor: Mansier P, Cassidy PS, Charlemagne D, Preteseille M, Lelievre LG

Publikováno v: FEBS letters [FEBS Lett] 1983 Mar 21; Vol. 153 (2), pp. 357-60.

Exogenous calmodulin increases Ca2+ sensitivity of isometric tension activation and myosin phosphorylation in skinned smooth muscle.

Autor: Cassidy PS, Kerrick WG, Hoar PE, Malencik DA

Publikováno v: Pflugers Archiv : European journal of physiology [Pflugers Arch] 1981 Dec; Vol. 392 (2), pp. 115-20.