Výsledky vyhledávání - "Cassiana Siebert"

P2X7 receptor deletion attenuates oxidative stress and liver damage in sepsis

Autor: Roberta Ciarlini-Magalhães, Tiago Marcon dos Santos, Angela T. S. Wyse, Christina Maeda Takiya, Maria Luciana Larrouyet-Sarto, Luiz Eduardo Baggio Savio, Cassiana Siebert, Thuany Prado Rangel, Augusto Shuiti Tamura, Robson Coutinho-Silva, Vinícius Santos Alves, Josiane R. Hartwig, Patricia T. Santana

Publikováno v: Purinergic Signal

Sepsis is a severe disease characterized by an uncontrolled systemic inflammation and consequent organ dysfunction generated in response to an infection. Extracellular ATP acting through the P2X7 receptor induces the maturation and release of pro-inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7665595abd61d19a87240486e422ffe
https://doi.org/10.1007/s11302-020-09746-7

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Changes in Inflammatory Response, Redox Status and Na+, K+-ATPase Activity in Primary Astrocyte Cultures from Female Wistar Rats Subject to Ovariectomy

Autor: A.T.S. Wyse, Cassiana Siebert, André Quincozes-Santos, Tiago Marcon dos Santos, Larissa Daniele Bobermin

Publikováno v: Neurotoxicity Research. 37:445-454

Astrocytes are dynamic glial cells that maintain brain homeostasis, particularly metabolic functions, inflammatory response, and antioxidant defense. Since menopause may be associated with brain dysfunction, in the present study, we evaluated anti- a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbca2e2bd48fa833450252bd76752393
https://doi.org/10.1007/s12640-019-00128-5

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Chronic mild Hyperhomocysteinemia impairs energy metabolism, promotes DNA damage and induces a Nrf2 response to oxidative stress in rats brain

Autor: Angela T. S. Wyse, Tiago Marcon dos Santos, Vanusa Manfredini, Cassiana Siebert, Micaela Federizzi de Oliveira

Publikováno v: Cellular and Molecular Neurobiology. 39:687-700

Homocysteine (HCY) has been linked to oxidative stress and varied metabolic changes that are dependent on its concentration and affected tissues. In the present study we evaluate parameters of energy metabolism [succinate dehydrogenase (SDH), complex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f60ec5076bc2a9139378ee88b0de4d
https://doi.org/10.1007/s10571-019-00674-8

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Mild Hyperhomocysteinemia Causes Anxiety-like Behavior and Brain Hyperactivity in Rodents: Are ATPase and Excitotoxicity by NMDA Receptor Overstimulation Involved in this Effect?

Autor: André Quincozes-Santos, Cassiana Siebert, Angela T. S. Wyse, Larissa Daniele Bobermin, Tiago Marcon dos Santos

Publikováno v: Cellular and molecular neurobiology. 42(8)

Mild hyperhomocysteinemia is a risk factor for psychiatric and neurodegenerative diseases, whose mechanisms between them are not well-known. In the present study, we evaluated the emotional behavior and neurochemical pathways (ATPases, glutamate home

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b21a68f5e7d89a97e9e4139c3a360ac
https://pubmed.ncbi.nlm.nih.gov/34324129

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Vitamin D partially reverses the increase in p‐NF‐κB/p65 immunocontent and interleukin‐6 levels, but not in acetylcholinesterase activity in hippocampus of adult female ovariectomized rats

Autor: Cassiana Siebert, Angela T. S. Wyse, Tiago Marcon dos Santos, Daniella de S Moreira, Carolina Gessinger Bertó, Fernanda Silva Ferreira

Publikováno v: International Journal of Developmental Neuroscience. 71:122-129

The aim of this study was to verify the effects of ovariectomy (OVX) and/or vitamin D supplementation (VIT D) on inflammatory and cholinergic parameters in hippocampus, as well as on serum estradiol and VIT D levels of rats. Ninety-day-old female Wis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f8d22fa05f2bedc7a0299e138bc8d9
https://doi.org/10.1016/j.ijdevneu.2018.08.008

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Vitamin D3 Reverses the Hippocampal Cytoskeleton Imbalance But Not Memory Deficits Caused by Ovariectomy in Adult Wistar Rats

Autor: Matheus Coimbra Sebotaio, Cassiana Siebert, Fernanda Silva Ferreira, Eduardo Peil Marques, Regina Pessoa-Pureur, Paula Pierozan, Helena Biasibetti, Carlos Alexandre Netto, Janaína Kolling, Aline Longoni, Tiago Marcon dos Santos, Angela T. S. Wyse

Publikováno v: NeuroMolecular Medicine. 19:345-356

The objective of study was to investigate changes caused by ovariectomy (OVX) on aversive and non-aversive memories, as well as on cytoskeleton phosphorylating system and on vitamin D receptor (VDR) immunocontent in hippocampus. The neuroprotective r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84f0c52e3dc831a64038cd38e2d7dca8
https://doi.org/10.1007/s12017-017-8449-7

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1,25-Dihydroxyvitamin D3 prevents deleterious effects of homocysteine on mitochondrial function and redox status in heart slices

Autor: Janaína Kolling, Aline Longoni, João Paulo dos Santos, Jussemara Souza da Silva, Adriano Martimbianco de Assis, Leo Anderson Meira-Martins, Cassiana Siebert, Angela T. S. Wyse, Letícia Ferreira Pettenuzzo, Carlos Alberto Gonçalves

Publikováno v: Nutrition Research. 38:52-63

Because homocysteine (Hcy) is a risk factor for cardiovascular disease, and vitamin D deficiency can contribute to cardiovascular pathologies. In the present study, we tested the hypothesis that Hcy could impair energy metabolism, mitochondrial funct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61fe93a9b0dfcc041e2f61abd2f269f0
https://doi.org/10.1016/j.nutres.2017.01.007

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Intrastriatal Quinolinic Acid Administration Impairs Redox Homeostasis and Induces Inflammatory Changes: Prevention by Kynurenic Acid

Autor: Angela T. S. Wyse, Eduardo Peil Marques, Felipe Schmitz, Fernanda Silva Ferreira, Cassiana Siebert

Publikováno v: Neurotoxicity research. 38(1)

Kynurenic acid (KYNA) and quinolinic acid (QUIN) are metabolites formed in the degradation of tryptophan (Trp). QUIN is a selective NMDA receptor antagonist and may exert neurotoxic effects, whereas KYNA is an agonist of glutamatergic and cholinergic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afd81d0392f1466dc21b43bbf77a37d
https://pubmed.ncbi.nlm.nih.gov/32219734

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Chronic mild hyperhomocysteinemia induces anxiety-like symptoms, aversive memory deficits and hippocampus atrophy in adult rats: New insights into physiopathological mechanisms

Autor: Carlos Alexandre Netto, Angela T. S. Wyse, Janaína Kolling, T.M. Dos Santos, Eduardo Farias Sanches, Cassiana Siebert

Publikováno v: Brain research. 1728

In the last decade, increased homocysteine levels have been implicated as a risk factor for neurodegenerative and psychiatric disorders. We have developed an experimental model of chronic mild hyperhomocysteinemia (HHcy) in order to observe metabolic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9d2b8aae98bec830784a4385fde553
https://pubmed.ncbi.nlm.nih.gov/31816318

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