Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Cassandra L. Ramage"'
Autor:
Yannan Jia, Lina Han, Cassandra L. Ramage, Zhe Wang, Connie C. Weng, Lei Yang, Simona Colla, Helen Ma, Weiguo Zhang, Michael Andreeff, Naval Daver, Nitin Jain, Naveen Pemmaraju, Kapil Bhalla, Satu Mustjoki, Peiyi Zhang, Guangrong Zheng, Daohong Zhou, Qi Zhang, Marina Konopleva
Publikováno v:
Haematologica, Vol 108, Iss 10 (2023)
BCL-XL and BCL-2 are key anti-apoptotic proteins and validated cancer targets. 753B is a novel BCL-XL/BCL-2 proteolysis targeting chimera (PROTAC) that targets both BCL-XL and BCL-2 to the von Hippel-Lindau (VHL) E3 ligase, leading to BCLX L/BCL-2 ub
Externí odkaz:
https://doaj.org/article/44723b7d8a04476c9f09a39b30c15fb8
Autor:
Qi Zhang, Bridget Riley-Gillis, Lina Han, Yanan Jia, Alessia Lodi, Haijiao Zhang, Saravanan Ganesan, Rongqing Pan, Sergej N. Konoplev, Shannon R. Sweeney, Jeremy A. Ryan, Yulia Jitkova, Kenneth Dunner, Shaun E. Grosskurth, Priyanka Vijay, Sujana Ghosh, Charles Lu, Wencai Ma, Stephen Kurtz, Vivian R. Ruvolo, Helen Ma, Connie C. Weng, Cassandra L. Ramage, Natalia Baran, Ce Shi, Tianyu Cai, Richard Eric Davis, Venkata L. Battula, Yingchang Mi, Jing Wang, Courtney D. DiNardo, Michael Andreeff, Jeffery W. Tyner, Aaron Schimmer, Anthony Letai, Rose Ann Padua, Carlos E. Bueso-Ramos, Stefano Tiziani, Joel Leverson, Relja Popovic, Marina Konopleva
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract Despite high initial response rates, acute myeloid leukemia (AML) treated with the BCL-2–selective inhibitor venetoclax (VEN) alone or in combinations commonly acquires resistance. We performed gene/protein expression, metabolomic and meth
Externí odkaz:
https://doaj.org/article/d7945566353e4cff944fa98c53fc192d
Autor:
Qi Zhang, Bridget Riley-Gillis, Lina Han, Yannan Jia, Alessia Lodi, Haijiao Zhang, Saravanan Ganesan, Rongqing Pan, Sergej N. Konoplev, Shannon R. Sweeney, Jeremy A. Ryan, Yulia Jitkova, Kenneth Dunner, Shaun E. Grosskurth, Priyanka Vijay, Sujana Ghosh, Charles Lu, Wencai Ma, Stephen Kurtz, Vivian R. Ruvolo, Helen Ma, Connie C. Weng, Cassandra L. Ramage, Natalia Baran, Ce Shi, Tianyu Cai, Richard Eric Davis, Venkata L. Battula, Yingchang Mi, Jing Wang, Courtney D. DiNardo, Michael Andreeff, Jeffery W. Tyner, Aaron Schimmer, Anthony Letai, Rose Ann Padua, Carlos E. Bueso-Ramos, Stefano Tiziani, Joel Leverson, Relja Popovic, Marina Konopleva
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/0bea0028687644349367928f6f176be8
Autor:
Yannan Jia, Lina Han, Cassandra L Ramage, Connie C. Weng, Lei Yang, Simona Colla, Helen Ma, Weiguo Zhang, Michael Andreeff, Naval Daver, Nitin Jain, Naveen Pemmaraju, Kapil N. Bhalla, Satu Mustjoki, Peiyi Zhang, Guangrong Zheng, Daohong Zhou, Qi Zhang, Marina Konopleva
Publikováno v:
Blood. 140:3347-3349
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b96387884c03220fe87842bf507e977
https://doi.org/10.1182/blood-2022-164541
https://doi.org/10.1182/blood-2022-164541
Autor:
Natalia Baran, Lina Han, Lucille Stuani, Antonio Cavazos, Laurie M. Cooper, Cassandra L. Ramage, Vinitha M. Kuruvilla, Qi Zhang, Marie Sabatier, Emeline Boet, Jason P. Gay, Ningping Feng, Lokesh Battula, Emeline Chu-Van, Florence Castelli, Martin Carrol, Sergej Konoplev, Beenu Thakral, Hagop M. Kantarjian, Naval Daver, Joseph Marszalek, Michael Andreeff, Jean-Emmanuel Sarry, Marina Konopleva
Publikováno v:
Blood Cancer Discovery. 4:A24-A24
Acute myeloid leukemia (AML) stem cells (AMLSCs) are thought to be responsible for disease initiation, chemoresistance and treatment failure. AMLSCs and residual cytarabine (AraC)-resistant AML cells (constituting minimal residual disease, MRD) were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::213121fec07d32eaa5a71862d7defe5a
https://doi.org/10.1158/2643-3249.aml23-a24
https://doi.org/10.1158/2643-3249.aml23-a24
Autor:
Natalia Baran, Shraddha Patel, Cassandra L Ramage, Alessia Lodi, Jose Enriquez Ortiz, Yogesh Dhungana, Meghan Collins, Anna Skwarska, Connie Weng, Kala Hayes, Zhihong Zeng, Laurie Cooper, Richard Eric Davis, Gheath Alatrash, Joseph R Marszalek, Jiyang Yu, Pratip K Bhattacharya, Stefano Tiziani, Marina Konopleva
Publikováno v:
Blood. 140:8831-8832
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97058679e9060e58ad16bebb3a6688c5
https://doi.org/10.1182/blood-2022-170713
https://doi.org/10.1182/blood-2022-170713
Autor:
Alessia Lodi, Jiyang Yu, Eric Davis, Gheath Alatrash, Anna Skwarska, Joseph R. Marszalek, Cassandra L Ramage, Marina Konopleva, Pratip K. Bhattacharya, Connie C. Weng, Natalia Baran, Kala Hayes, Meghan Collins, Stefano Tiziani, Shraddha Patel, Zhihong Zeng, Yogesh Dhungana, Jose Enriquez Ortiz
Publikováno v:
Blood. 138:680-680
Metabolic reprogramming is recognized as one of the key hallmarks in acquiring aggressive phenotype and chemoresistance in solid tumors and hematologic malignancies. We have previously demonstrated that T-ALL are characterized by significant dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ad02802d67be17f273821aa8e29cf89
https://doi.org/10.1182/blood-2021-152845
https://doi.org/10.1182/blood-2021-152845
Autor:
Shelley M. Herbrich, Yuki Nishida, Connie C. Weng, Cassandra L Ramage, Mark P. Chao, Yannan Jia, Naval Daver, Roy Louis Maute, Michael Andreeff, Qi Zhang, Weiguo Zhang, Marina Konopleva
Publikováno v:
Blood. 138:510-510
CD47 expressed on cells functions as a "don't eat me" signal by binding SIRPa on macrophages and blocking phagocytosis. Cancer cells including AML evade phagocytosis by overexpressing CD47, and high CD47 expression in AML has been associated with inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb87a2b467ecd8cf5f03ec8338df8283
https://doi.org/10.1182/blood-2021-147479
https://doi.org/10.1182/blood-2021-147479