Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Cassandra K Hayne"'
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135447 (2015)
Mycobacterium tuberculosis harbors over 160 genes encoding PE/PPE proteins, several of which have roles in the pathogen's virulence. A number of PE/PPE proteins are secreted via Type VII secretion systems known as the ESX secretion systems. One PE pr
Externí odkaz:
https://doaj.org/article/9ef0013cda7144d49e32575daab18155
Autor:
Monica C. Pillon, Meredith N. Frazier, Lucas B. Dillard, Jason G. Williams, Seda Kocaman, Juno M. Krahn, Lalith Perera, Cassandra K. Hayne, Jacob Gordon, Zachary D. Stewart, Mack Sobhany, Leesa J. Deterding, Allen L. Hsu, Venkata P. Dandey, Mario J. Borgnia, Robin E. Stanley
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nsp15 is a uridine specific endoribonuclease present in all coronaviruses. Here, the authors determine the cryo-EM structures of SARS-CoV-2 Nsp15 in the apo and UTP-bound states, which together with biochemical experiments, mass spectrometry and mole
Externí odkaz:
https://doaj.org/article/3b3bd68422cc4508a02721056de1a082
Autor:
Cassandra K. Hayne, Kevin John U. Butay, Zachary D. Stewart, Juno M. Krahn, Lalith Perera, Jason G. Williams, Robert M. Petrovitch, Leesa J. Deterding, A. Gregory Matera, Mario J. Borgnia, Robin E. Stanley
Across all walks of life, certain transfer RNA (tRNA) transcripts contain introns. Pre-tRNAs with introns require splicing to form the mature anticodon stem loop (ASL). In eukaryotes, tRNA splicing is initiated by the heterotetrameric tRNA splicing e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac763c77b08f3f0f5d0e63fa16f7b75
https://doi.org/10.1101/2022.09.02.506201
https://doi.org/10.1101/2022.09.02.506201
Publikováno v:
WIREs RNA. 13
The splicing of transfer RNA (tRNA) introns is a critical step of tRNA maturation, for intron-containing tRNAs. In eukaryotes, tRNA splicing is a multi-step process that relies on several RNA processing enzymes to facilitate intron removal and exon l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51eec0fbc795c19f79caeab954034817
https://doi.org/10.1002/wrna.1717
https://doi.org/10.1002/wrna.1717
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df7e7391573cd221fcb4e499989844cc
https://doi.org/10.1096/fasebj.2021.35.s1.00444
https://doi.org/10.1096/fasebj.2021.35.s1.00444
Autor:
Lucas B. Dillard, Cassandra K. Hayne, Meredith N Frazier, Lalith Perera, Robin E. Stanley, Allen L. Hsu, Leesa J. Deterding, Jason Williams, Zachary D. Stewart, Mario J. Borgnia, Jacob Gordon, Venkata P. Dandey, Monica C. Pillon, Mack Sobhany, Seda Kocaman, Juno M. Krahn
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
bioRxiv
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
bioRxiv
Nsp15, a uridine specific endoribonuclease conserved across coronaviruses, processes viral RNA to evade detection by host defense systems. Crystal structures of Nsp15 from different coronaviruses have shown a common hexameric assembly, yet how the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fd88fa61a41e36bf913df39126d8bfb
Autor:
Monica C. Pillon, Meredith N. Frazier, Lucas B. Dillard, Jason G. Williams, Seda Kocaman, Juno M. Krahn, Lalith Perera, Cassandra K. Hayne, Jacob Gordon, Zachary D. Stewart, Mack Sobhany, Leesa J. Deterding, Allen L. Hsu, Venkata P. Dandey, Mario J. Borgnia, Robin E. Stanley
Publikováno v:
Nature Communications
Nsp15, a uridine specific endoribonuclease conserved across coronaviruses, processes viral RNA to evade detection by host defense systems. Crystal structures of Nsp15 from different coronaviruses have shown a common hexameric assembly, yet how the en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c681bcbdd8d24dd78f6f58a25417f339
https://pubmed.ncbi.nlm.nih.gov/33504779
https://pubmed.ncbi.nlm.nih.gov/33504779
Publikováno v:
Nucleic Acids Res
The splicing of tRNA introns is a critical step in pre-tRNA maturation. In archaea and eukaryotes, tRNA intron removal is catalyzed by the tRNA splicing endonuclease (TSEN) complex. Eukaryotic TSEN is comprised of four core subunits (TSEN54, TSEN2, T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af92f19aad904f0127f74840fca0ea42
https://pubmed.ncbi.nlm.nih.gov/32476018
https://pubmed.ncbi.nlm.nih.gov/32476018
The splicing of tRNA introns is a critical step in pre-tRNA maturation. In archaea and eukaryotes, tRNA intron removal is catalyzed by the tRNA splicing endonuclease (TSEN) complex. Eukaryotic TSEN is comprised of four core subunits (TSEN54, TSEN2, T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301dc59e33ed60d40414e88cf73d9a80
Publikováno v:
Biochemistry. 56:525-533
Lipoprotein lipase (LPL) is responsible for the hydrolysis of triglycerides from circulating lipoproteins. Whereas most identified mutations in the LPL gene are deleterious, one mutation, LPLS447X, causes a gain of function. This mutation truncates t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93a6052f19c12e3fac1eefaae2e246d2
https://doi.org/10.1021/acs.biochem.6b00945
https://doi.org/10.1021/acs.biochem.6b00945