HERVs establish a distinct molecular subtype in stage II/III colorectal cancer with poor outcome

Autor: Mahdi Golkaram, Michael L. Salmans, Shannon Kaplan, Raakhee Vijayaraghavan, Marta Martins, Nafeesa Khan, Cassandra Garbutt, Aaron Wise, Joyee Yao, Sandra Casimiro, Catarina Abreu, Daniela Macedo, Ana Lúcia Costa, Cecília Alvim, André Mansinho, Pedro Filipe, Pedro Marques da Costa, Afonso Fernandes, Paula Borralho, Cristina Ferreira, Fernando Aldeia, João Malaquias, Jim Godsey, Alex So, Traci Pawlowski, Luis Costa, Shile Zhang, Li Liu

Publikováno v: npj Genomic Medicine, Vol 6, Iss 1, Pp 1-11 (2021)

Abstract Colorectal cancer (CRC) is one of the most lethal malignancies. The extreme heterogeneity in survival rate is driving the need for new prognostic biomarkers. Human endogenous retroviruses (hERVs) have been suggested to influence tumor progre

Externí odkaz: https://doaj.org/article/957481dcdc6e4e478acc8a847c3b62c1

MicroRNA-mRNA networks define translatable molecular outcome phenotypes in osteosarcoma

Autor: David H. Ebb, Cassandra Garbutt, Christopher E. Lietz, Brian Lawney, Vikram Deshpande, Zhenfeng Duan, Yen-Lin Chen, Francis J. Hornicek, Dimitrios Spentzos, Santiago A. Lozano-Calderon, G. Petur Nielsen, Benjamin Haibe-Kains, Gregory M. Cote, John Quackenbush, William T. Barry, Yaoyu E. Wang, Edwin Choy

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific reports, vol 10, iss 1
Scientific Reports

BackgroundThere is a lack of well validated biomarkers in osteosarcoma, a rare, recalcitrant disease with variable outcome and poorly understood biologic behavior, for which treatment standards have stalled for decades. The only standard prognostic f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca039caccc14ac83bdb0f2362b2f8d2
http://link.springer.com/article/10.1038/s41598-020-61236-3

An imprinted non-coding genomic cluster at 14q32 defines clinically relevant molecular subtypes in osteosarcoma across multiple independent datasets

Autor: Dimitrios Spentzos, William H. Barry, Cassandra Garbutt, G.M. Cote, Haydn T. Kissick, Mark C. Gebhardt, John Quackenbush, Francis J. Hornicek, Jeff Goldsmith, Katherine A. Janeway, Ahmed Rattani, Katherine E. Hill, Edwin Choy, Antonio R. Perez-Atayde, Marieke L. Kuijjer, Mohamed S. Arredouani, Zhenfeng Duan, Andrew Kelly, Benjamin Haibe-Kains

Publikováno v: Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-22 (2017)
Journal of Hematology & Oncology

Background A microRNA (miRNA) collection on the imprinted 14q32 MEG3 region has been associated with outcome in osteosarcoma. We assessed the clinical utility of this miRNA set and their association with methylation status. Methods We integrated codi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6cf6c4a570b5fdb661050950db15327
http://link.springer.com/article/10.1186/s13045-017-0465-4

Clinical and Molecular Analysis of Pathologic Fracture-associated Osteosarcoma: MicroRNA profile Is Different and Correlates with Prognosis

Autor: Dimitrios Spentzos, Ivan Chebib, Yen-Lin Chen, Cassandra Garbutt, Kevin A. Raskin, John Quackenbush, Yaoyu E. Wang, G. Petur Nielsen, Vikram Deshpande, Karen De Amorim Bernstein, Gregory M. Cote, Renee Rubio, Thomas F. DeLaney, Jason Kim, Christopher E. Lietz, Joseph H. Schwab, Santiago A. Lozano Calderón

Publikováno v: Clin Orthop Relat Res

Background MicroRNAs are small, noncoding RNAs that regulate the expression of posttranslational genes. The presence of some specific microRNAs has been associated with increased risk of both local recurrence and metastasis and worse survival in pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8813d3925720b1d8837401893cf079
https://pubmed.ncbi.nlm.nih.gov/31389890

Intragenic antagonistic roles of protein and circRNA in tumorigenesis

Autor: Cassandra Garbutt, Jesse Katon, Antonella Papa, Carlos Cordon-Cardo, Mark Simpson, Cristian Loretelli, Spentzos Dimitrios, John G. Clohessy, Pier Paolo Pandolfi, Andreas Petri, Akinobu Matsumoto, Mona Batish, Riccardo Panella, Jlenia Guarnerio, Vikram Deshpande, Sakari Kauppinen, Gunnlaugur P. Nielsen, Giulia Cheloni, Yang Zhang, Mireia Castillo-Martin

Publikováno v: Guarnerio, J, Zhang, Y, Cheloni, G, Panella, R, Mae Katon, J, Simpson, M, Matsumoto, A, Papa, A, Loretelli, C, Petri, A, Kauppinen, S, Garbutt, C, Petur Nielsen, G, Deshpande, V, Castillo-Martin, M, Cordon-Cardo, C, Dimitrios, S, Clohessy, J G, Batish, M & Pandolfi, P P 2019, ' Intragenic antagonistic roles of protein and circRNA in tumorigenesis ', Cell Research, vol. 29, no. 8, pp. 628-640 . https://doi.org/10.1038/s41422-019-0192-1
Cell Res

circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20f5fb07d4781923862ecd99002fa22
https://pubmed.ncbi.nlm.nih.gov/31911670