Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Cassandra E Thompson"'
Autor:
Forrest C Walker, Ebrahim Hassan, Stefan T Peterson, Rachel Rodgers, Lawrence A Schriefer, Cassandra E Thompson, Yuhao Li, Gowri Kalugotla, Carla Blum-Johnston, Dylan Lawrence, Broc T McCune, Vincent R Graziano, Larissa Lushniak, Sanghyun Lee, Alexa N Roth, Stephanie M Karst, Timothy J Nice, Jonathan J Miner, Craig B Wilen, Megan T Baldridge
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009402 (2021)
Interferons (IFNs) are key controllers of viral replication, with intact IFN responses suppressing virus growth and spread. Using the murine norovirus (MNoV) system, we show that IFNs exert selective pressure to limit the pathogenic evolutionary pote
Externí odkaz:
https://doaj.org/article/90fb07bf8a2e40fb883cfc49c1867b66
Autor:
Catherine A. Doyle, Gregory W. Busey, Wesley H. Iobst, Volker Kiessling, Chloe Renken, Hansa Doppalapudi, Marta E. Stremska, Mohan C. Manjegowda, Mohd Arish, Weiming Wang, Shardul Naphade, Joel Kennedy, Louis-Marie Bloyet, Cassandra E. Thompson, Paul W. Rothlauf, Eric J. Stipes, Sean P. J. Whelan, Lukas K. Tamm, Alex J. B. Kreutzberger, Jie Sun, Bimal N. Desai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The majority of viruses classified as pandemic threats are enveloped viruses which enter the cell through receptor-mediated endocytosis and take advantage of endosomal acidification to activate their fusion machinery. Here we report that the
Externí odkaz:
https://doaj.org/article/dee6605d5bdc48a684b5ee4df122fe09
Autor:
Marjorie C Pontelli, Ítalo A Castro, Ronaldo B Martins, Leonardo La Serra, Flávio P Veras, Daniele C Nascimento, Camila M Silva, Ricardo S Cardoso, Roberta Rosales, Rogério Gomes, Thais M Lima, Juliano P Souza, Brenda C Vitti, Diego B Caetité, Mikhael H F de Lima, Spencer D Stumpf, Cassandra E Thompson, Louis-Marie Bloyet, Juliana E Toller-Kawahisa, Marcela C Giannini, Letícia P Bonjorno, Maria I F Lopes, Sabrina S Batah, Li Siyuan, Rodrigo Luppino-Assad, Sergio C L Almeida, Fabiola R Oliveira, Maíra N Benatti, Lorena L F Pontes, Rodrigo C Santana, Fernando C Vilar, Maria Auxiliadora-Martins, Pei-Yong Shi, Thiago M Cunha, Rodrigo T Calado, José C Alves-Filho, Dario S Zamboni, Alexandre T Fabro, Paulo Louzada-Junior, Rene D R Oliveira, Sean P J Whelan, Fernando Q Cunha, Eurico Arruda
Publikováno v:
Journal of Molecular Cell Biology. 14
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a hyperinflammatory state and lymphocytopenia, a hallmark that appears as both signature and prognosis of disease severity outcome. Although cytokine storm
Autor:
Dong Hee Chung, Partha Karmakar, Michael A Tartell, Andrea M. Klingler, Vishnu C. Damalanka, Markus Hoffmann, Cassandra E Thompson, Sean P. J. Whelan, Matthew Mahoney, Stefan Pöhlmann, Paul W. Rothlauf, Melody Lee, Jorine Voss, Anthony J. O’Donoghue, André Luiz Lourenço, Charles S. Craik, Christina L. Stallings, Marc E. Rothenberg, James W. Janetka, Nurit P. Azouz, Anne E. Mayer Bridwell, Dustin Pwee, Lidija Klampfer
Publikováno v:
bioRxiv
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 43
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 43
Proceedings of the National Academy of Sciences of the United States of America
Significance MM3122 represents an advanced lead candidate for clinical development as a novel antiviral drug for COVID-19. In addition to being novel drugs, these selective TMRSS2 inhibitors can be used as valuable chemical probes to help elucidate m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375bc698f0a068ad5bcd60e5bac8a49a
https://europepmc.org/articles/PMC8204910/
https://europepmc.org/articles/PMC8204910/
Autor:
Victoria R. Saykally, Cassandra E. Thompson, Joshua J. Glazier, Timothy Notton, Leor S. Weinberger
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
It has long been known that noncoding genomic regions can be obligate cis elements acted upon in trans by gene products. In viruses, cis elements regulate gene expression, encapsidation, and other maturation processes, but mapping these elements reli
Autor:
Timothy, Notton, Joshua J, Glazier, Victoria R, Saykally, Cassandra E, Thompson, Leor S, Weinberger
Publikováno v:
mBio
Recent studies have renewed interest in developing novel antiviral therapeutics and vaccines based on defective interfering particles (DIPs)—a subset of viral deletion mutants that conditionally replicate. Identifying and engineering DIPs require t
Autor:
Alexa N. Roth, Lawrence A. Schriefer, Cassandra E Thompson, Rachel Rodgers, Megan T. Baldridge, Jonathan J. Miner, Yuhao Li, Ebrahim Hassan, Stephanie M. Karst, Forrest C. Walker, Dylan Lawrence, Carla Blum-Johnston, Sanghyun Lee, Vincent R. Graziano, Broc T. McCune, Gowri Kalugotla, Larissa Lushniak, Stefan T. Peterson, Craig B. Wilen, Timothy J. Nice
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 3, p e1009402 (2021)
PLoS Pathogens, Vol 17, Iss 3, p e1009402 (2021)
Interferons (IFNs) are key controllers of viral replication, with intact IFN responses suppressing virus growth and spread. Using the murine norovirus (MNoV) system, we show that IFNs exert selective pressure to limit the pathogenic evolutionary pote
Autor:
Charles Chin, Cassandra E. Thompson, Michael L. Simpson, Brandon S. Razooky, Leor S. Weinberger, Roy D. Dar, Elena Ingerman, Winnie Y. Wen, Maike M. K. Hansen
Publikováno v:
Cell. 173:1609-1621.e15
Diverse biological systems utilize fluctuations (‘noise’) in gene-expression to drive lineage-commitment decisions. However, once a commitment is made, noise becomes detrimental to reliable function, and the mechanisms enabling post-commitment no