Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Cassandra D. M. Churchill"'
Autor:
Alicja Kuban-Jankowska, Magdalena Gorska, Jack A. Tuszynski, Cassandra D. M. Churchill, Philip Winter, Mariusz Klobukowski, Michal Wozniak
Publikováno v:
Cellular Physiology and Biochemistry, Vol 36, Iss 3, Pp 1069-1083 (2015)
Background/Aims: Protein tyrosine phosphatases are crucial enzymes controlling numerous physiological and pathophysiological events and can be regulated by oxidation of the catalytic domain cysteine residue. Peracids are highly oxidizing compounds, a
Externí odkaz:
https://doaj.org/article/f809817639ac42f7907393a705927769
Autor:
Marc St George, Ahmed T Ayoub, Asok Banerjee, Cassandra D M Churchill, Philip Winter, Mariusz Klobukowski, Carol E Cass, Richard F Ludueña, Jack A Tuszynski, Sambasivarao Damaraju
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129168 (2015)
Our previous work identified an intermediate binding site for taxanes in the microtubule nanopore. The goal of this study was to test derivatives of paclitaxel designed to bind to this intermediate site differentially depending on the isotype of β-t
Externí odkaz:
https://doaj.org/article/f52f0efb56234a809812dbd19309eb40
Publikováno v:
iScience, Vol 11, Iss, Pp 42-56 (2019)
iScience
iScience
Summary The emerging field of bioelectricity has revealed numerous new roles for ion channels beyond the nervous system, which can be exploited for applications in regenerative medicine. Developing such biomedical interventions for birth defects, can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5041f44adf159f0d49928b2c312923df
http://www.sciencedirect.com/science/article/pii/S2589004218302323
http://www.sciencedirect.com/science/article/pii/S2589004218302323
Probing the Basis of α-Synuclein Aggregation by Comparing Simulations to Single-Molecule Experiments
Autor:
Cassandra D. M. Churchill, Jordane Preto, Michael T. Woodside, Jack A. Tuszynski, Mark A. Healey
Publikováno v:
Biophys J
Intrinsically disordered proteins often play an important role in protein aggregation. However, it is challenging to determine the structures and interactions that drive the early stages of aggregation because they are transient and obscured in a het
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::120c41c816b9ae01b1200aabf2a9320f
https://pubmed.ncbi.nlm.nih.gov/31477241
https://pubmed.ncbi.nlm.nih.gov/31477241
Autor:
Cassandra D. M. Churchill, Frederick G. West, Peter E. Ghaly, Jack A. Tuszynski, Rabab M. Abou El-Magd
Publikováno v:
Oncotarget
// Peter E. Ghaly 1 , Rabab M. Abou El-Magd 2, 4 , Cassandra D. M. Churchill 1 , Jack A. Tuszynski 2, 3 , F. G. West 1 1 Department of Chemistry, University of Alberta, Edmonton, AB T6G 2G2, Canada 2 Department of Oncology, University of Alberta, Edm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc41f6b55822645407ef3e8ee213e921
https://doi.org/10.18632/oncotarget.9642
https://doi.org/10.18632/oncotarget.9642
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 34:1455-1469
Laulimalide (LA) is a microtubule-stabilizing agent, currently in preclinical studies. However, studying the binding of this species and successfully synthesizing potent analogues have been challenging. The LA binding site is located between tubulin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89e1bcb35f14056152b5a625258404c
https://doi.org/10.1080/07391102.2015.1078115
https://doi.org/10.1080/07391102.2015.1078115
Publikováno v:
The Journal of Physical Chemistry B. 120:1195-1204
Four uracil-containing intrastrand cross-links have been detected in human cells upon UV irradiation of 5-bromouracil-containing DNA, namely 5'-G[8-5]U-3', 5'-U[5-8]G-3', 5'-A[8-5]U-3', and 5'-A[2-5]U-3'. These lesions feature unique composition and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fbb6f919d2ed3708a3d81cdfec82c1
https://doi.org/10.1021/acs.jpcb.5b10381
https://doi.org/10.1021/acs.jpcb.5b10381
Autor:
Jordane Preto, Francesco Gentile, Jack A. Tuszynski, Sara Ibrahim Omar, Cassandra D. M. Churchill, Philip Winter
Publikováno v:
Springer Proceedings in Mathematics & Statistics ISBN: 9783319765983
The main objective of this review chapter is to give the reader a practical toolbox for applications in quantitative biology and computational drug discovery. The computational technique of molecular dynamics is discussed, with special attention to f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2752968fb14957b5f789dd6e1f47ccb6
https://doi.org/10.1007/978-3-319-76599-0_14
https://doi.org/10.1007/978-3-319-76599-0_14
Publikováno v:
Chemical Biology & Drug Design. 86:1253-1266
The clinically approved taxanes (paclitaxel, docetaxel and cabazitaxel) target the tubulin protein in microtubules. Despite the clinical success of these agents, the mechanism of action of this class of drugs remains elusive, making rational design o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3975e5ddeefb85f65bbaea7f43f62b77
https://doi.org/10.1111/cbdd.12595
https://doi.org/10.1111/cbdd.12595
Autor:
Philip Winter, Jack A. Tuszynski, Michal Wozniak, Mariusz Klobukowski, Magdalena M. Gorska, Alicja Kuban-Jankowska, Cassandra D. M. Churchill
Publikováno v:
Cellular Physiology and Biochemistry, Vol 36, Iss 3, Pp 1069-1083 (2015)
Background/Aims: Protein tyrosine phosphatases are crucial enzymes controlling numerous physiological and pathophysiological events and can be regulated by oxidation of the catalytic domain cysteine residue. Peracids are highly oxidizing compounds, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ba4fa61d14fbd0ad54183532856380
http://www.karger.com/Article/FullText/430280
http://www.karger.com/Article/FullText/430280