Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Cassandra A Boguth"'
Full-length Gαq–phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain
Publikováno v:
Nature structural & molecular biology
Phospholipase C-β (PLCβ) is directly activated by Gαq, but the molecular basis for how its distal C-terminal domain (CTD) contributes to maximal activity is poorly understood. Herein we present both the crystal structure and cryo-EM three-dimensio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c6e9d064a243e0af5efcec10fc4e7c
https://doi.org/10.1038/nsmb.2497
https://doi.org/10.1038/nsmb.2497
Structure and Function of Heterotrimeric G Protein-Regulated Rho Guanine Nucleotide Exchange Factors
Publikováno v:
Molecular Pharmacology. 77:111-125
Activation of certain classes of G protein-coupled receptors (GPCRs) can lead to alterations in the actin cytoskeleton, gene transcription, cell transformation, and other processes that are known to be regulated by Rho family small-molecular-weight G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76c21923e3741d4e33d22608fc72c95a
https://doi.org/10.1124/mol.109.061234
https://doi.org/10.1124/mol.109.061234
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b6d144f4ecd881c395cd3865553f438
https://doi.org/10.1096/fasebj.27.1_supplement.656.1
https://doi.org/10.1096/fasebj.27.1_supplement.656.1
Autor:
Valerie M. Tesmer, John J.G. Tesmer, Angeline M. Lyon, John K. Northup, Vishan D. Dhamsania, David M. Thal, Joanne Guiterrez, Cassandra A. Boguth, Shoaib Chowdhury
Publikováno v:
The FASEB Journal. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d191afb3626648e88ba5c92ce5e7022c
https://doi.org/10.1096/fasebj.26.1_supplement.667.1
https://doi.org/10.1096/fasebj.26.1_supplement.667.1
Publikováno v:
The FASEB Journal. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3f3deaa08689163f895f7d1c80b7445
https://doi.org/10.1096/fasebj.25.1_supplement.lb404
https://doi.org/10.1096/fasebj.25.1_supplement.lb404
Publikováno v:
The EMBO journal. 29(19)
G protein-coupled receptor (GPCR) kinases (GRKs) selectively recognize and are allosterically regulated by activated GPCRs, but the molecular basis for this interaction is not understood. Herein, we report crystal structures of GRK6 in which regions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f06806a83e497af94fc34f4656c235
https://pubmed.ncbi.nlm.nih.gov/20729810
https://pubmed.ncbi.nlm.nih.gov/20729810
Autor:
Franca Uhlemann, Susanne Lutz, Cassandra A. Boguth, Aruna Shankaranarayanan, Christiane Vettel, Mohamed Aittaleb, John J.G. Tesmer, Thomas Wieland
Galpha(q) directly activates p63RhoGEF and closely related catalytic domains found in Trio and Kalirin, thereby linking G(q)-coupled receptors to the activation of RhoA. Although the crystal structure of G alpha(q) in complex with the catalytic domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a3362fe5071d8ca86ba6b169dadad5
https://europepmc.org/articles/PMC2862694/
https://europepmc.org/articles/PMC2862694/
