Effect of TNBS-induced colitis on enteric neuronal subpopulations in adult zebrafish

Autor: Leen Uyttebroek, Casper Pype, Guy Hubens, Jean-Pierre Timmermans, Luc van Nassauw

Publikováno v: European Journal of Histochemistry, Vol 64, Iss 3 (2020)

Inflammatory bowel disease (IBD) includes inflammation of the gastrointestinal (GI) tract and is characterized by periods of acute inflammation and remission. Therapeutic management of IBD is still problematic, because of incomplete understanding its

Externí odkaz: https://doaj.org/article/e0be6a5dc844457a8a91f7d0e70e1505

UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes

Autor: Moayad Saad, Sebastiaan Bijttebier, An Matheeussen, Evy Verbueken, Casper Pype, Christophe Casteleyn, Chris Van Ginneken, Louis Maes, Paul Cos, Steven Van Cruchten

Publikováno v: Data in Brief, Vol 16, Iss , Pp 644-648 (2018)

This article represents data regarding a study published in Toxicology in vitro entitled “ in vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds” (Saad et al., 2017) [1]. Data were acquired with ultra-per

Externí odkaz: https://doaj.org/article/48e3e647dda84afaa61eb29259879acf

UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes

Autor: Christophe Casteleyn, An Matheeussen, Louis Maes, Sebastiaan Bijttebier, Evy Verbueken, Moayad A. Saad, Steven Van Cruchten, Casper Pype, Paul Cos, Chris Van Ginneken

Publikováno v: Data in Brief
Data in Brief, Vol 16, Iss, Pp 644-648 (2018)

This article represents data regarding a study published in Toxicology in vitro entitled "in vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds" (Saad et al., 2017) [1]. Data were acquired with ultra-performa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71f94fecd3ea3288eabb9ec502c0e18
https://doi.org/10.1016/j.dib.2017.11.079

Incubation at 32.5°C and above causes malformations in the zebrafish embryo

Autor: Christophe Casteleyn, Evy Verbueken, Dries Knapen, Casper Pype, Moayad A. Saad, Steven Van Cruchten, Chris J. Van Ginneken

Publikováno v: Reproductive toxicology

Zebrafish embryos are increasingly used for developmental toxicity screening of candidate drugs and are occasionally co-incubated with a metabolic activation system at 32 °C for 1, 2 or 4 h, depending on their developmental stage. As this temperatur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3d1610e1459045b42185cbe15471de
https://doi.org/10.1016/j.reprotox.2015.05.006

In Vitro Biotransformation of Two Human CYP3A Probe Substrates and Their Inhibition during Early Zebrafish Development

Autor: Chris Van Ginneken, Steven Van Cruchten, Els Van Peer, Christophe Casteleyn, Casper Pype, Evy Verbueken, Moayad A. Saad, Derek Alsop, Joanna Y. Wilson

Publikováno v: International Journal of Molecular Sciences, Vol 18, Iss 1, p 217 (2017)
International journal of molecular sciences
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 18; Issue 1; Pages: 217

At present, the zebrafish embryo is increasingly used as an alternative animal model to screen for developmental toxicity after exposure to xenobiotics. Since zebrafish embryos depend on their own drug-metabolizing capacity, knowledge of their intrin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3299c1c236f2c883aa8e72d2e3fa4127
http://www.mdpi.com/1422-0067/18/1/217