Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Casper K Lumby"'
Publikováno v:
eLife, Vol 9 (2020)
Strains of the influenza virus form coherent global populations, yet exist at the level of single infections in individual hosts. The relationship between these scales is a critical topic for understanding viral evolution. Here we investigate the wit
Externí odkaz:
https://doaj.org/article/9ed1d3bb14354e0391c9594d3391f019
Publikováno v:
PLoS Genetics, Vol 14, Iss 10, p e1007718 (2018)
Transmission between hosts is a critical part of the viral lifecycle. Recent studies of viral transmission have used genome sequence data to evaluate the number of particles transmitted between hosts, and the role of selection as it operates during t
Externí odkaz:
https://doaj.org/article/c80309154add4771ac16bf8941a89adb
Autor:
Nicolas J. Walker, Mamunur Rashid, Shirong Yu, Helen Bignell, Casper K. Lumby, Carmen M. Livi, Kate Howell, David J. Morley, Sandro Morganella, Daniel Barrell, Shabhonam Caim, Walraj Gosal, Jens Füllgrabe, Thomas J. Charlesworth, Louella Vasquez, Miika Ahdesmäki, Jordan Eizenga, Parul Prabhat, Vitali Proutski, Marie Laurie Murat-Onana, Catherine J. Greenwood, Lisa Kirkwood, Meeta Maisuria-Armer, Mengjie Li, Emma Coats, Victoria Winfield, Lachlan MacBean, Toby Stock, Alice Tomé-Fernandez, Yat Chan, Nasir Sheikh, Paula Golder, Michael Steward, Tobias W. B. Ost, Douglas Stewart, Albert Vilella, Mojtaba Noursalehi, Benedict Paten, Debora Lucarelli, Joanne Mason, Gareth Ridge, Jason Mellad, Suman Shirodkar, Shankar Balasubaramanian, Joanna D. Holbrook
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Early detection of cancer will improve survival rates. The blood biomarker 5-hydroxymethylcytosine has been shown to discriminate cancer. In a large covariate-controlled study of over two thousand individual blood samples, we created, tested
Externí odkaz:
https://doaj.org/article/d0f8987336da4809bf0d43cd15a3ea02
Autor:
Jens Füllgrabe, Walraj S. Gosal, Páidí Creed, Sidong Liu, Casper K. Lumby, David J. Morley, Tobias W. B. Ost, Albert J. Vilella, Shirong Yu, Helen Bignell, Philippa Burns, Tom Charlesworth, Beiyuan Fu, Howerd Fordham, Nicolas J. Harding, Olga Gandelman, Paula Golder, Christopher Hodson, Mengjie Li, Marjana Lila, Yang Liu, Joanne Mason, Jason Mellad, Jack M. Monahan, Oliver Nentwich, Alexandra Palmer, Michael Steward, Minna Taipale, Audrey Vandomme, Rita Santo San-Bento, Ankita Singhal, Julia Vivian, Natalia Wójtowicz, Nathan Williams, Nicolas J. Walker, Nicola C. H. Wong, Gary N. Yalloway, Joanna D. Holbrook, Shankar Balasubramanian
Publikováno v:
Nature Biotechnology.
DNA comprises molecular information stored in genetic and epigenetic bases, both of which are vital to our understanding of biology. Most DNA sequencing approaches address either genetics or epigenetics and thus capture incomplete information. Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d8005a9ad5fe3c2a23faf8b6338fb23
https://doi.org/10.1038/s41587-022-01652-0
https://doi.org/10.1038/s41587-022-01652-0
Autor:
Jens Füllgrabe, Walraj S Gosal, Páidí Creed, Sidong Liu, Casper K Lumby, David J Morley, Tobias W B Ost, Albert J Vilella, Shirong Yu, Helen Bignell, Philippa Burns, Tom Charlesworth, Beiyuan Fu, Howerd Fordham, Nick Harding, Olga Gandelman, Paula Golder, Christopher Hodson, Mengjie Li, Marjana Lila, Yang Liu, Joanne Mason, Jason Mellad, Jack Monahan, Oliver Nentwich, Alexandra Palmer, Michael Steward, Minna Taipale, Audrey Vandomme, Rita Santo San-Bento, Ankita Singhal, Julia Vivian, Natalia Wójtowicz, Nathan Williams, Nicolas J Walker, Nicola C H Wong, Gary Yalloway, Joanna D Holbrook, Shankar Balasubaramanian
DNA comprises molecular information stored via genetic bases (G, C, T, A) and also epigenetic bases, principally 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). Both genetic and epigenetic information are vital to our understanding of biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac2af7acf13559572475f1c21b6cbf27
https://doi.org/10.1101/2022.07.08.499285
https://doi.org/10.1101/2022.07.08.499285
Autor:
Fabio Puddu, Casper K. Lumby, Nick Harding, David J. Morley, Jamie Scotcher, Robert Crawford, Jens Füllgrabe, Walraj S. Gosal, Shirong Yu, Daniel Brudzewsky, Jane Haywood, Andrada Tomoni, Philippa Burns, Joanna D. Holbrook, Paidi Creed
Publikováno v:
Cancer Research. 83:6602-6602
Liquid biopsy for profiling of cell free DNA (cfDNA) in blood holds huge promise to transform how we experience and manage cancer by early detection and identification of residual disease and subtype. However, a standard blood draw yields an average
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f4fa5e12c44cd2ab268ab0a366036b6
https://doi.org/10.1158/1538-7445.am2023-6602
https://doi.org/10.1158/1538-7445.am2023-6602
Autor:
Helena J. Tutill, Tim Best, Rachel Williams, Judy Breuer, Austen Worth, Macarena Oporto, Paul Veys, Casper K Lumby, Christopher J. R. Illingworth, Lei Zhao, Divya K. Shah
Publikováno v:
Clinical Infectious Diseases. 71:e191-e194
A combination of favipiravir and zanamivir successfully cleared influenza B infection in a child who had undergone bone marrow transplant for X-linked severe combined immunodeficiency, with no recovery of T lymphocytes. Deep sequencing of viral sampl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39c708ced9e78d38b2efd316951d110
https://doi.org/10.1093/cid/ciaa023
https://doi.org/10.1093/cid/ciaa023
Publikováno v:
Journal of Virology
Viral populations undergo a repeated cycle of within-host growth followed by transmission. Viral evolution is affected by each stage of this cycle. The number of viral particles transmitted from one host to another, known as the transmission bottlene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c55a9588df1049dad0daec068661eed
https://eprints.gla.ac.uk/253370/1/253370.pdf
https://eprints.gla.ac.uk/253370/1/253370.pdf
Strains of the influenza virus form coherent global populations, yet exist at the level of single infections in individual hosts. The relationship between these scales is a critical topic for understanding viral evolution. Here we investigate the wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635c45585416412a7f0059ab8c3fd422