Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Casper, Hempel"'
Autor:
Arjen Weller, Morten B. Hansen, Rodolphe Marie, Adam C. Hundahl, Casper Hempel, Paul J. Kempen, Henrik L. Frandsen, Ladan Parhamifar, Jannik B. Larsen, Thomas L. Andresen
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Unsuccessful clinical translation of orally delivered biological drugs remains a challenge in pharmaceutical development and has been linked to insufficient mechanistic understanding of intestinal drug transport. Live cell imaging could provide such
Externí odkaz:
https://doaj.org/article/e425fcb8956a43f1a5293643c45fd42a
Autor:
Serhii Kostrikov, Kasper B. Johnsen, Thomas H. Braunstein, Johann M. Gudbergsson, Frederikke P. Fliedner, Elisabeth A. A. Obara, Petra Hamerlik, Anders E. Hansen, Andreas Kjaer, Casper Hempel, Thomas L. Andresen
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Kostrikov et al. report a deficiency of transcardial perfusion in brain tumor vasculature, which leads to exaggeration of drug extravasation measurements. They then demonstrate how optical tissue clearing can help to overcome this limitation and prov
Externí odkaz:
https://doaj.org/article/351a278571824c1bab11d20eb4f1160f
Autor:
Diána Hudecz, Sara Björk Sigurdardóttir, Sarah Christine Christensen, Casper Hempel, Andrew J Urquhart, Thomas Lars Andresen, Morten S Nielsen
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249686 (2021)
The blood-brain barrier (BBB) is one of the main obstacles for therapies targeting brain diseases. Most macromolecules fail to pass the tight BBB, formed by brain endothelial cells interlinked by tight junctions. A wide range of small, lipid-soluble
Externí odkaz:
https://doaj.org/article/922698fa4c0a47eb9b69cb886bed49d9
Autor:
Filip C. Castberg, Lasse Maretty, Trine Staalsoe, Casper Hempel, Erik Clasen-Linde, Lars Hviid, Jørgen A. L. Kurtzhals
Publikováno v:
Malaria Journal, Vol 17, Iss 1, Pp 1-12 (2018)
Abstract Background Iron deficiency is the most widespread nutrient deficiency and an important cause of developmental impairment in children. However, some studies have indicated that iron deficiency can also protect against malaria, which is a lead
Externí odkaz:
https://doaj.org/article/c445d8c587374ee18f92d8baa5cfae9b
Publikováno v:
Malaria Journal, Vol 16, Iss 1, Pp 1-11 (2017)
Abstract Background Plasmodium falciparum-infected erythrocytes sequester in the microcirculation due to interaction between surface-expressed parasite proteins and endothelial receptors. Endothelial cells are covered in a carbohydrate-rich glycocaly
Externí odkaz:
https://doaj.org/article/dc697c3769fa4cec9d1478e961e00eaf
Publikováno v:
Danielsen, M, Hempel, C, Andresen, T L & Urquhart, A J 2022, ' Biopharmaceutical nanoclusters: Towards the self-delivery of protein and peptide therapeutics ', Journal of controlled release, vol. 347, pp. 282-307 . https://doi.org/10.1016/j.jconrel.2022.04.050
Protein and peptide biopharmaceuticals have had a major impact on the treatment of a number of diseases. There is a growing interest in overcoming some of the challenges associated with biopharmaceuticals, such as rapid degradation in physiological f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f0138058cd4a71d1b249ce36221b28
https://doi.org/10.1016/j.jconrel.2022.04.050
https://doi.org/10.1016/j.jconrel.2022.04.050
Publikováno v:
The Journal of Infectious Diseases. 226:1470-1479
BackgroundCerebral malaria (CM) is a rare, but severe and frequently fatal outcome of infection with Plasmodium falciparum. Pathogenetic mechanisms include endothelial activation and sequestration of parasitized erythrocytes in the cerebral microvess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad23bc178e4a6f728eb532f63de3403e
https://doi.org/10.1093/infdis/jiac200
https://doi.org/10.1093/infdis/jiac200
Autor:
Brian DellaValle, Alba Manresa-Arraut, Henrik Hasseldam, Allan Stensballe, Jørgen Rungby, Agnete Larsen, Casper Hempel
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
IntroductionMultiple sclerosis (MS) is a devastating autoimmune disease, afflicting people in the prime of their lives. Presently, after initial clinical presentation, there are no reliable markers for whether a patient will develop MS, or whether th
Externí odkaz:
https://doaj.org/article/c2f175ffbc9f486b82b42a3320915616
Investigating dye performance and crosstalk in fluorescence enabled bioimaging using a model system.
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188359 (2017)
Detailed imaging of biological structures, often smaller than the diffraction limit, is possible in fluorescence microscopy due to the molecular size and photophysical properties of fluorescent probes. Advances in hardware and multiple providers of h
Externí odkaz:
https://doaj.org/article/171aec2c692248ada8cad11e3dae1fcb
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189529 (2017)
The popularity of fluorescence microscopy arises from the inherent mode of action, where the fluorescence emission from probes is used to visualize selected features on a presumed dark background. However, the background is rarely truly dark, and ima
Externí odkaz:
https://doaj.org/article/5c4a3bc70add4fb899439aeff7e1bfce