Associations of long-term exposure to air pollution and noise with body composition in children and adults: Results from the LEAD general population study

Autor: Hicran Altug, Katherine Ogurtsova, Robab Breyer-Kohansal, Caspar Schiffers, Alina Ofenheimer, Lilian Tzivian, Sylvia Hartl, Barbara Hoffmann, Sarah Lucht, Marie-Kathrin Breyer

Publikováno v: Environment International, Vol 189, Iss , Pp 108799- (2024)

Background: While long-term air pollution and noise exposure has been linked to increasing cardiometabolic disease risk, potential effects on body composition remains unclear. This study aimed to investigate the associations of long-term air pollutio

Externí odkaz: https://doaj.org/article/340acd623e824e4d800bac59679a8abc

Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies

Autor: Caspar Schiffers, Niki L. Reynaert, Emiel F. M. Wouters, Albert van der Vliet

Publikováno v: Antioxidants, Vol 10, Iss 11, p 1799 (2021)

With a rapidly growing elderly human population, the incidence of age-related lung diseases such as chronic obstructive pulmonary disease (COPD) continues to rise. It is widely believed that reactive oxygen species (ROS) play an important role in age

Externí odkaz: https://doaj.org/article/6f3022a396f0489db2db729818152b76

Prevalence of restrictive lung function in children and adults in the general population

Autor: Caspar Schiffers, Alina Ofenheimer, Marie-Kathrin Breyer, Tobias Mraz, Bernd Lamprecht, Otto Chris Burghuber, Sylvia Hartl, Emiel F.M. Wouters, Robab Breyer-Kohansal

Publikováno v: Respiratory Medicine, 210:107156. Elsevier Saunders

Background: Restrictive lung function (RLF) is characterized by a reduced lung expansion and size. In the absence of lung volume measurements, restriction can be indirectly assessed with restrictive spirometric patterns (RSP) by spirometry. Prevalenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b798a988f4869eaa52c945ea735139
https://doi.org/10.1016/j.rmed.2023.107156

Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema

Autor: Christopher M. Dustin, Nirav Daphtary, Caspar Schiffers, Lennart K. A. Lundblad, Niki L. Reynaert, Emiel F.M. Wouters, Albert van der Vliet, Minara Aliyeva, David J. Seward, Milena Hristova, Yvonne M. W. Janssen-Heininger, Aida Habibovic

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology, 321(1), L144-L158. American Physiological Society
Am J Physiol Lung Cell Mol Physiol

Aging is associated with a gradual loss of lung function due to increased cellular senescence, decreased regenerative capacity, and impaired innate host defense. One important aspect of innate airway epithelial host defense to nonmicrobial triggers i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7b682d676a388c62b278898341509c
https://doi.org/10.1152/ajplung.00021.2021

The Transient Receptor Potential Channel Vanilloid 1 Is Critical in Innate Airway Epithelial Responses to Protease Allergens

Autor: Christopher M. Dustin, Caspar Schiffers, Aida Habibovic, Niki L. Reynaert, Milena Hristova, Karamatullah Danyal, Emiel F.M. Wouters, Albert van der Vliet

Publikováno v: American Journal of Respiratory Cell and Molecular Biology, 63(2), 198-208. American Thoracic Society
Am J Respir Cell Mol Biol

The airway epithelium plays a critical role in innate responses to airborne allergens by secreting IL-1 family cytokines such as IL-1 alpha and IL-33 as alarmins that subsequently orchestrate appropriate immune responses. Previous studies revealed th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814fc8ca72168db75d483cf27c8b3abf
https://doi.org/10.1165/rcmb.2019-0170oc