Further development of local IL-2 therapy of cancer: multiple versus single IL-2 treatment of transplanted murine colon carcinoma

Autor: Willem Den Otter, Halina Kusnierczyk, Krzysztof Krawczyk, Caspaar Bijleveld, Elżbieta Pajtasz-Piasecka, J. W. Koten

Publikováno v: Cancer Immunology, Immunotherapy. 53:445-452

We have compared the effect of one and up to four local IL-2 treatments of transplanted MC38 colon carcinoma. A single IL-2 treatment prolonged the survival time ( p=0.015), but no cure was obtained. One local IL-2 treatment inhibited tumor growth fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d648ee67ef7552bf9c34d66e35049853
https://doi.org/10.1007/s00262-003-0490-8

Studies on the intracellular localization of acetyl-CoA carboxylase

Autor: Ronald J.A. Wanders, Caspaar Bijleveld, Math J.H. Geelen, Guillermo Velasco, Manuel Guzmán

Publikováno v: Biochemical and biophysical research communications, 233(1), 253-257. Academic Press Inc.
Biochemical and Biophysical Research Communications, 233, 253-257. Academic Press Inc.

The present work was performed to identify the subcellular localization of hepatic acetyl-CoA carboxylase (ACC). Cellular organelles involved in fatty acid oxidation that contain a malonyl-CoA sensitive carnitine palmitoyltransferase (CPT) activity o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0e8556639a7f31d7bec3afbfb3bd95
https://doi.org/10.1006/bbrc.1997.6437

Ovariectomy decreases plasma triglyceride levels in analbuminaemic rats by lowering hepatic triglyceride secretion

Autor: Caspaar Bijleveld, Arie van Tol, Jaap A. Joles, Hein A. Koomans, Math J.H. Geelen

Publikováno v: Atherosclerosis. 117:51-59

In mutant analbuminaemic rats (NAR), females demonstrate a more marked hypertriglyceridaemia than males. Ovariectomy decreases triglyceride levels in female NAR. We measured triglyceride secretion rates in vivo as well as the activity of acetyl CoA c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c41be2df7ee6c4d3f2e4f2c2751c81a
https://doi.org/10.1016/0021-9150(95)05557-d

Galectins as markers of aggressiveness of mouse mammary carcinoma: towards a lectin target therapy of human breast cancer

Autor: E. V. Moiseeva, E. M. Rapoport, J. E. Van Dijk, N. V. Bovin, Anatoly I. Miroshnikov, Caspaar Bijleveld, M. S. Krasilshschikova, A. V. Chaadaeva, V. K. Bojenko, W. Den Otter

Publikováno v: Breast cancer research and treatment. 91(3)

Galectins, beta-galactoside binding proteins, expressed selectively in human breast carcinoma are attractive targets to employ lectin-aimed therapeutics. We examined beta-galactoside binding potency of neoplastic cells using fluorescein-labelled synt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caac43d97fac129ebf21de9b2c4b87ba
https://pubmed.ncbi.nlm.nih.gov/15952056

Estrogen Replacement During Hypoalbuminemia May Enhance Atherosclerotic Risk

Autor: Math J.H. Geelen, Caspaar Bijleveld, J. A. Joles, A. van Tol, Hendrik A. Koomans

Publikováno v: Journal of the American Society of Nephrology, 1870-1876. American Society of Nephrology
ISSUE=8;STARTPAGE=1870;ENDPAGE=1876;ISSN=1046-6673;TITLE=Journal of the American Society of Nephrology

Estrogen replacement therapy is considered antiatherosclerotic because it reduces LDL cholesterol and fibrinogen and increases HDL cholesterol concentrations. However, exogenous estrogen is also known to increase hepatic triglyceride production. Hype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85599f93dcb76c68271f378d5c7402a
https://pure.eur.nl/en/publications/6398867e-b687-42b4-9aa6-7b5fe5ad67f8