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Supplemental Tables 1 through 3 from Lysyl Oxidase Is a Strong Determinant of Tumor Cell Colonization in Bone

Autor: Philippe Clézardin, Marie Brevet, Antoine E. Karnoub, Géraldine Aimond, Clémence Thomas, Floriane Pez, Edith Bonnelye, Martine Croset, Casina Kan, Paola Di Mauro, Laura Ferreras, Caroline Reynaud

Supplementary Table S1. Primer pairs used for quantitative real-time PCR analysis. Supplementary Table S2. Summary of the gene expression datasets used for meta-analysis. Supplementary Table S3. Expression levels of LOX-like mRNAs in Hct116 cells tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41cb0f506b1611ac8ebf2bea535cb7aa
https://doi.org/10.1158/0008-5472.22411907.v1

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Data from Lysyl Oxidase Is a Strong Determinant of Tumor Cell Colonization in Bone

Lysyl oxidase (LOX) is a secreted copper-dependent amine oxidase whose primary function is to drive collagen crosslinking and extracellular matrix stiffness. LOX in colorectal cancer synergizes with hypoxia-inducible factor-1 (HIF-1) to promote tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fa6ac9faf7030fa3eb06539061a20c7
https://doi.org/10.1158/0008-5472.c.6508325.v1

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Supplemental Figures 1 through 7 from Lysyl Oxidase Is a Strong Determinant of Tumor Cell Colonization in Bone

Figure S1: LOX expression and clinical outcomes. Figure S2:The LOX inhibitor βAPN inhibits osteolytic lesion formation in vivo. Figure S3: Measurement of LOX enzymatic activity. Figure S4: Correlation analysis of the expression intensity of LOX and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed28ac88e4401f5ca74264c0790f9bf
https://doi.org/10.1158/0008-5472.22411910.v1

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Lack of Association Between Select Circulating miRNAs and Bone Mass, Turnover, and Fractures: Data From the OFELY Cohort

Autor: Elodie Feurer, Martine Croset, Elisabeth Sornay-Rendu, Roland Chapurlat, Casina Kan

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 34(6)

Postmenopausal osteoporosis is characterized by the occurrence of fragility fracture with an increase in morbidity and mortality. Recently, microRNAs (miRNAs) have raised interest as regulators of translational repression, mediating a number of key p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aac8ec88d0df73b6cab7b6b47bb0627
https://pubmed.ncbi.nlm.nih.gov/30830972

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Abstract 486: MicroRNA-30 family members inhibit breast cancer invasion, osteomimicry, and bone destruction by directly targeting multiple bone metastasis-associated genes

Autor: Martine Croset, Francesco Pantano, Casina Kan, Edith Bonnelye, Francoise Descotes, Catherine Alix-Panabières, Charles Lecellier, Richard Bachelier, Nathalie Allioli, Saw See Hong, Kai Bartkowiak, Klaus Pantel, Philippe Clézardin

Publikováno v: Cancer Research. 78:486-486

MicroRNAs (miRNAs), which are master regulators of gene expression, have emerged as key players in cancer metastasis. Here, we established miR-30 family members (miR-30a, miR-30b, miR-30c, miR-30d and miR-30e) as breast cancer bone metastasis suppres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91a3d008251f0edb49e57de1a1bd438a
https://doi.org/10.1158/1538-7445.am2018-486

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Abstract 2584: Mutations in low-grade serous ovarian cancer and response to BRAF and MEK inhibitors

Autor: Tania Moujaber, Dariush Etemadmoghadam, Cristina Mapagu, Catherine Kennedy, Yoke-Eng Chiew, Casina Kan, Nikilyn Nevins, Sivatharsny Srirangan, Sian Fereday, Nadia Traficante, Australian Ovarian Cancer Study group, David Bowtell, Rosemary Balleine, Paul Harnett, Anna deFazio

Publikováno v: Cancer Research. 78:2584-2584

Low-grade serous ovarian cancer (LGSC) responds poorly to platinum based chemotherapy and is characterized by activating RAS-MAPK pathway mutations, including oncogenic BRAF. Drugs that target this pathway are effective in BRAF-mutant melanoma but ot

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https://doi.org/10.1158/1538-7445.am2018-2584

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Genomic alterations as mediators of miRNA dysregulation in ovarian cancer

Autor: Deborah J. Marsh, Michael A Hahn, Viive M. Howell, Casina Kan

Publikováno v: Genes, Chromosomes and Cancer. 54:1-19

Ovarian cancer is the fifth most common cause of cancer death in women worldwide. Serous epithelial ovarian cancer (SEOC) is the most common and aggressive histological subtype. Widespread genomic alterations go hand-in-hand with aberrant DNA damage

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https://doi.org/10.1002/gcc.22221

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Publikováno v: Oncotarget
Oncotarget, Impact journals, 2016, 7 (47), pp.77071-77086. ⟨10.18632/oncotarget.12787⟩
Oncotarget, 2016, 7 (47), pp.77071-77086. ⟨10.18632/oncotarget.12787⟩

International audience; Bone metastases are one of the main complications of prostate cancer and they are incurable. We investigated whether and how estrogen receptor-related receptor alpha (ERRalpha) is involved in bone tumor progression associated

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