Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Casimir, Blonski"'
Autor:
Cécile Baudoin-Dehoux, Casimir Blonski, Frédéric Rodriguez, David Soupaya, Pascal Hoffmann, Martine Briet, Franciane Ho A Kwie, Marie Maturano, Christian Lherbet
Publikováno v:
Chemical Biology & Drug Design. 77:86-92
Bisubstrate-type compound Lys-CoA has been shown to inhibit the p300 histone acetyl transferase activity efficiently and may constitute a lead compound for a novel class of anticancer therapeutics. Based on this strategy, we synthesized a series of C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f418f082047bac1ffabccfa20bbe3875
https://doi.org/10.1111/j.1747-0285.2010.01056.x
https://doi.org/10.1111/j.1747-0285.2010.01056.x
Publikováno v:
Synthetic Communications. 40:1082-1087
A series of carboxylic acids were converted into their corresponding methyl esters using bismuth(III) triflate as a catalyst in methanol. Good to excellent yields were obtained for different aliphatic or aromatic starting materials. In the reaction,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb4058cf168d5440d2fe63446197b37c
https://doi.org/10.1080/00397910903046846
https://doi.org/10.1080/00397910903046846
Autor:
Joseph Parello, Casimir Blonski, Ruth A. Gjerset, Jean-Louis Banères, Aimée Martin, Keya Bandyopadhyay
Publikováno v:
Cell Cycle. 8:2779-2788
Acetyl group turnover on specific lysine epsilon-amino groups of the core chromosomal histones regulates DNA accessibility function, and the acetylating and deacetylating enzymes that govern the turnover provide important targets for the development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61264775f7b61872790f7b92b535cef
https://doi.org/10.4161/cc.8.17.9416
https://doi.org/10.4161/cc.8.17.9416
Publikováno v:
Biochemistry. 48:4528-4537
Fructose-1,6-bisphosphate muscle aldolase is an essential glycolytic enzyme that catalyzes reversible carbon-carbon bond formation by cleaving fructose 1,6-bisphosphate to yield dihydroxyacetone phosphate (DHAP) and d-glyceraldehyde phosphate. To elu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6edeb8a08ea723acb7382e5d08849761
https://doi.org/10.1021/bi8021558
https://doi.org/10.1021/bi8021558
Autor:
Jérôme Dellacasagrande, Gérard Tiraby, Angélique Durand Dal-Maso, Casimir Blonski, Frédéric Legendre, Pascal Hoffmann
Publikováno v:
European Journal of Medicinal Chemistry. 43:1758-1766
The preparation of a series of novel water soluble cationic lipid derivatives possessing phosphonate ester groups linked to the para-position of N-methyl pyridinium moieties and bearing either identical or different alkyl chains is reported. The obta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e16d10dd68adf58236e3183b1b6adb
https://doi.org/10.1016/j.ejmech.2007.11.002
https://doi.org/10.1016/j.ejmech.2007.11.002
Publikováno v:
Synthetic Communications. 38:1688-1693
A procedure for the introduction of two different alkyl chains (myristyl, oleyl and phytanyl) leading to heterodialkyl‐H‐phosphonates is reported, based on two successive transesterification reactions of commercially available diphenyl‐H‐phos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec8a053e685c8ec7700c6b0931583519
https://doi.org/10.1080/00397910801982282
https://doi.org/10.1080/00397910801982282
Autor:
Marcos V.A.S. Navarro, Daniel J. Rigden, M. T. S. Giotto, Sandra Martha Gomes Dias, Richard Charles Garratt, Sabine Gavalda, Luciane V. Mello, Casimir Blonski
Publikováno v:
FEBS Journal. 274:5077-5089
Enolase is a validated drug target in Trypanosoma brucei. To better characterize its properties and guide drug design efforts, we have determined six new crystal structures of the enzyme, in various ligation states and conformations, and have carried
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47c489fd0a9e7ad60a6ba41cda1cc6d7
https://doi.org/10.1111/j.1742-4658.2007.06027.x
https://doi.org/10.1111/j.1742-4658.2007.06027.x
Autor:
Casimir Blonski, Jurgen Sygusch, Mathieu Coincon, Paul A.M. Michels, Chantal Dax, Nicolas Chabot, Francis Duffieux
Publikováno v:
Journal of Medicinal Chemistry. 49:1499-1502
An irreversible competitive inhibitor hydroxynaphthaldehyde phosphate was synthesized that is highly selective against the glycolytic enzyme fructose 1,6-bisphosphate aldolase from Trypanosoma brucei (causative agent of sleeping sickness). Inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73562f8ad4350960c3b647279e3de1f7
https://doi.org/10.1021/jm050237b
https://doi.org/10.1021/jm050237b
Publikováno v:
Biochemistry. 44:5430-5443
Interactions of phosphate derivatives of 2,6-dihydroxynaphthalene (NA-P(2)) and 1,6-dihydroxy-2-naphthaldehyde (HNA-P, phosphate at position 6) with fructose-1,6-bisphosphate aldolase from rabbit muscle were analyzed by enzyme kinetics, difference sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65c2ef425616790cada45c9e538399fd
https://doi.org/10.1021/bi0477992
https://doi.org/10.1021/bi0477992
Publikováno v:
Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2004, 12, pp.2965-2972. ⟨10.1016/j.bmc.2004.03.039⟩
Bioorganic and Medicinal Chemistry, 2004, 12, pp.2965-2972. ⟨10.1016/j.bmc.2004.03.039⟩
Bioorganic and Medicinal Chemistry, Elsevier, 2004, 12, pp.2965-2972. ⟨10.1016/j.bmc.2004.03.039⟩
Bioorganic and Medicinal Chemistry, 2004, 12, pp.2965-2972. ⟨10.1016/j.bmc.2004.03.039⟩
2-Keto-3-deoxy-6-phosphogluconate (KDPG) aldolase is a key enzyme in the Entner–Doudoroff pathway of bacteria. It catalyzes the reversible production of KDPG from pyruvate and d -glyceraldehyde 3-phosphate through a class I Schiff base mechanism. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::731bd634ad065354c9291ea226ae8a3e
https://doi.org/10.1016/j.bmc.2004.03.039
https://doi.org/10.1016/j.bmc.2004.03.039