Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Casim A. Sarkar"'
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Energy landscapes can provide intuitive depictions of population heterogeneity and dynamics. However, it is unclear whether individual cell behavior, hypothesized to be determined by initial position and noise, is faithfully recapitulated. U
Externí odkaz:
https://doaj.org/article/dbd72642ec304b8a925f90879db4a4ef
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract A limited number of accessible and representative models of human trophoblast cells currently exist for the study of placentation. Current stem cell models involve either a transition through a naïve stem cell state or precise dynamic contr
Externí odkaz:
https://doaj.org/article/8939c68ec69b4d698b7275fdae324fdf
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Arising through multiple binding elements, multivalency can specify the avidity, duration, cooperativity, and selectivity of biomolecular interactions, but quantitative prediction and design of these properties has remained challenging. Here the auth
Externí odkaz:
https://doaj.org/article/4632e55c80a540eeaf858c70fac5eede
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Site-specific recombination (SSR) is an important tool in synthetic biology, but its applications are limited by the inability to predictably tune SSR reaction rates. Here, using quantitative high-throughput experiments and machine learning, the auth
Externí odkaz:
https://doaj.org/article/7f7889d4d2ad476dacac02e6588e024f
Autor:
George C. Markou, Casim A. Sarkar
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Plant immune receptors are often difficult to express heterologously, hindering study of direct interactions between these receptors and their targets with traditional biochemical approaches. The cell-free method ribosome display (RD) enable
Externí odkaz:
https://doaj.org/article/b98896deaf604f76a05d79e840e7c07e
Autor:
Najaf A. Shah, Casim A. Sarkar
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-12 (2019)
Abstract Background Modules of interacting components arranged in specific network topologies have evolved to perform a diverse array of cellular functions. For a network with a constant topological structure, its function within a cell may still be
Externí odkaz:
https://doaj.org/article/2e106f526efa4f79abdf811f9221b0a4
Autor:
Santhosh Palani, Casim A. Sarkar
Publikováno v:
Cell Reports, Vol 1, Iss 3, Pp 215-224 (2012)
Progenitor cells within a clonal population show variable proclivity toward lineage commitment and differentiation. This cell-to-cell variability has been attributed to transcriptome-wide gene expression noise generated by fluctuations in the amount
Externí odkaz:
https://doaj.org/article/fdcb14701e014238bab6559e1ae22ea4
Autor:
Ayako Ohoka, Casim A. Sarkar
Publikováno v:
ACS Synthetic Biology. 12:634-638
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55508199453029cfe327e1822d0f183b
https://doi.org/10.1021/acssynbio.2c00563
https://doi.org/10.1021/acssynbio.2c00563
Publikováno v:
bioRxiv
SummaryEnergy landscapes can provide intuitive depictions of population heterogeneity and dynamics. However, it is unclear whether individual cell behavior, hypothesized to be determined by initial position and noise, is faithfully recapitulated. Usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31bc6a303fe4cf0f50612fd1b52b3cc7
https://doi.org/10.1101/2023.05.22.541793
https://doi.org/10.1101/2023.05.22.541793
Publikováno v:
Applied Biochemistry and Biotechnology. 194:1636-1644
Sea lamprey immunization can yield leucine-rich repeat (LRR) protein binders analogous to globular antibodies developed from mammals. A novel minimal LRR was discovered through lamprey immunization with human immunoglobulin G Fc domain (IgG Fc). Init
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::110e9897e040c6e8d5ad525f6b89468c
https://doi.org/10.1007/s12010-021-03768-6
https://doi.org/10.1007/s12010-021-03768-6