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Influence of Cholesterol on the Oxygen Permeability of Membranes: Insight from Atomistic Simulations
Publikováno v:
Biophys J
Cholesterol is widely known to alter the physical properties and permeability of membranes. Several prior works have implicated cell membrane cholesterol as a barrier to tissue oxygenation, yet a good deal remains to be explained with regard to the m
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783319388083
High cellular membrane cholesterol is known to generate membrane resistance and reduce oxygen (O2) permeability. As such, cholesterol may contribute to the Warburg effect in tumor cells by stimulating intracellular hypoxia that cannot be detected fro
Cross-Validation of Simulation and EPR Oximetry Approaches: Membrane Cholesterol Reduces Oxygen Flux
Publikováno v:
Biophysical Journal. 110(3)
Prior EPR oximetry work by Subczynski and colleagues has shown that cholesterol increases membrane resistance to oxygen permeation by 3- to 5-fold when present in a 1:1 ratio with phospholipid. In the current study, we use molecular dynamics simulati
Publikováno v:
Biophysical Journal. 110:411a
Molecular oxygen delivery to mitochondria is essential for aerobic metabolism. Oxygen must diffuse across multiple membranes on the cellular and tissue levels. A steady supply of oxygen is essential for normal cellular bioenergetics, so even modest m
Publikováno v:
Experimental and Molecular Pathology. 90:320-321
Publikováno v:
World Journal of Hepatology. 3:275
In the November 27, 2010 issue of the World Journal of Hepatology (WJH), three case reports were published which involved patients who had consumed various dietary supplements and conventional foods generally marketed as weight loss products. The ref
Autor:
Casey R. Smith
Publikováno v:
Nutrition Bulletin. 28:226-226