Vinculin regulates directionality and cell polarity in two- and three-dimensional matrix and three-dimensional microtrack migration

Autor: Marsha C. Lampi, Francois Bordeleau, Zachary E. Goldblatt, Andrés J. García, Casey M. Kraning-Rush, Aniqua Rahman, Deanna Y. Lin, Cynthia A. Reinhart-King, Shawn P. Carey

Publikováno v: Molecular Biology of the Cell. 27:1431-1441

During metastasis, cells can use proteolytic activity to form tube-like “microtracks” within the extracellular matrix (ECM). Using these microtracks, cells can migrate unimpeded through the stroma. To investigate the molecular mechanisms of micro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e94a0a7bbe6d32aac35bcb6ae8b7475
https://doi.org/10.1091/mbc.e15-06-0432

Vinculin Regulates Directionality and Cell Polarity in 2D, 3D Matrix and 3D Microtrack Migration

Autor: Aniqua, Rahman, Shawn P, Carey, Casey M, Kraning-Rush, Zachary E, Goldblatt, Francois, Bordeleau, Marsha C, Lampi, Deanna Y, Lin, Andrés J, García, Cynthia A, Reinhart-King

Publikováno v: Molecular Biology of the Cell

Cells can maneuver through 3D matrices by using tracks that exist in the matrix. The focal adhesion protein vinculin mediates the unidirectional movement through these tracks. Moreover, vinculin also promotes directional migration in 2D and 3D matric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::847274c87045e224da5aae493f6ba80d
https://pubmed.ncbi.nlm.nih.gov/26960796

A physical sciences network characterization of non-tumorigenic and metastatic cells

Autor: Deirdre R. Meldrum, Hariharan Subramanian, David B. Agus, Yiider Tseng, Mark C. Lloyd, Claudia Fischbach, Kevin G. Philips, Thea D. Tlsty, Biana Godin, Jan Liphardt, Guillaume Lambert, Jonathan D. Licht, Matthew R. Dallas, Yue Geng, Jack R. Staunton, Kevin S. Kung, Jasmine Foo, Chira Chen-Tanyolac, Roger H. Johnson, Patti Senechal, Kelly Bethel, Kuldeepsinh Rana, Robert A. Gatenby, Veronica Estrella, Valerie M. Weaver, Scott S. Verbridge, Richard Bonneau, Eric C. Holland, Matthew J. Paszek, Cynthia A. Reinhart-King, Joseph E. Aslan, Wei Chiang Chen, Michael R. King, Alex Greenfield, Ahyoung Joo, Mauro Ferrari, Philippe Gascard, Vivek Nandakumar, Vadim Backman, Franziska Michor, Tyler Jacks, Sharon Gerecht, John F. Marko, Courtney Hemphill, S.P. Ashili, Laimonas Kelbauskas, Casey M. Kraning-Rush, Yolanda Stypula, Stephanie I. Fraley, Brian J. Kwee, Wadih Arap, Thomas V. O'Halloran, Abigail Hielscher, Luis Estévez-Salmerón, Jonathan E. Katz, Steven A. Curley, Arig Ibrahim-Hashim, Robert J. Gillies, Shannon M. Mumenthaler, Christine Will, Peter Kuhn, Srimeenakshi Srinivasan, Dhwanil Damania, Garth W. Tormoen, Parag Mallick, Robert H. Austin, Christian Frantz, Jenny C. Wan, Anna Lyubimova, Michael L. Shuler, Konstantinos Konstantopoulos, Nathan C. Choi, Jonathan W. Wojtkowiak, Carl Kesselman, Paolo Decuzzi, Paul Davies, Laura E. Dickinson, Gregg L. Semenza, Renata Pasqualini, Liyu Liu, Pei Hsun Wu, Barbara L. Hempstead, David Liao, W. Daniel Hillis, Owen J. T. McCarty, Robert Ros, Jenolyn F. Alexander, Alexander Fuhrmann, Jonathan Widom, Steve Oh, William M. Grady, Johnathon N. Lakins, Denis Wirtz, Alexander van Oudenaarden, Christopher S. Poultney

Publikováno v: Scientific Reports

To investigate the transition from non-cancerous to metastatic from a physical sciences perspective, the Physical Sciences–Oncology Centers (PS-OC) Network performed molecular and biophysical comparative studies of the non-tumorigenic MCF-10A and m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102c02fe957a17f01ad615604ee20289
http://europepmc.org/articles/PMC3636513

Controlling matrix stiffness and topography for the study of tumor cell migration

Autor: Cynthia A. Reinhart-King, Casey M. Kraning-Rush

Cellular studies have long been performed on the bench top, within Petri dishes and flasks that expose cells to surroundings that differ greatly from their native environment. The complexity of a human tissue is such that to truly replicate a cell’

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c90af3a9f61d1245072fac1b66a5c1a
https://europepmc.org/articles/PMC3427241/

Biophysical control of invasive tumor cell behavior by extracellular matrix microarchitecture

Autor: Casey M. Kraning-Rush, Cynthia A. Reinhart-King, Rebecca M. Williams, Shawn P. Carey

Publikováno v: Biomaterials. 33(16)

Fibrillar collagen gels, which are used extensively in vitro to study tumor–microenvironment interactions, are composed of a cell-instructive network of interconnected fibers and pores whose organization is sensitive to polymerization conditions su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe63b5e02ff1b4ce6f9e5c328c92584
https://pubmed.ncbi.nlm.nih.gov/22405848