Výsledky vyhledávání - "Casey L. Kilpatrick"

DHHC7 Palmitoylates Glucose Transporter 4 (Glut4) and Regulates Glut4 Membrane Translocation

Autor: Casey L. Kilpatrick, Keyong Du, Bernhard Lüscher, Shoko Murakami, Yingmin Sun

Publikováno v: Journal of Biological Chemistry. 292:2979-2991

Insulin-dependent translocation of glucose transporter 4 (Glut4) to the plasma membrane plays a key role in the dynamic regulation of glucose homeostasis. We recently showed that this process is critically dependent on palmitoylation of Glut4 at Cys-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c215c35a6193e5f1b7eac568c25bbd4c
https://doi.org/10.1074/jbc.m116.747139

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Dissociation of Golgi-associated DHHC-type Zinc Finger Protein (GODZ)- and Sertoli Cell Gene with a Zinc Finger Domain-β (SERZ-β)-mediated Palmitoylation by Loss of Function Analyses in Knock-out Mice

Autor: Keyong Du, Casey L. Kilpatrick, Shoko Murakami, Gong Chen, Bernhard Lüscher, Xia Wu, Rachnanjali Lal, Mengyang Feng

Publikováno v: Journal of Biological Chemistry. 291:27371-27386

The γ2 subunit of GABA type A receptors (GABAARs) is thought to be subject to palmitoylation by both Golgi-associated DHHC-type zinc finger protein (GODZ; also known as DHHC3) and its paralog Sertoli cell gene with a zinc finger domain-β (SERZ-β;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61fbe08ee9863f755fbf444dc19861b
https://doi.org/10.1074/jbc.m116.732768

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The Absence of DHHC3 Affects Primary and Latent Herpes Simplex Virus 1 Infection

Autor: Shaohui Wang, Marianne Cilluffo, Shoko Murakami, Sita Awasthi, Alexander V. Ljubimov, Konstantin G. Kousoulas, Homayon Ghiasi, Bernhard Lüscher, Kevin R. Mott, Casey L. Kilpatrick

Publikováno v: Journal of virology, vol 92, iss 4

UL20, an essential herpes simplex virus 1 (HSV-1) protein, is involved in cytoplasmic envelopment of virions and virus egress. We reported recently that UL20 can bind to a host protein encoded by the zinc finger DHHC-type containing 3 ( ZDHHC3 ) gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430dd8d01142c601d47c98cf31fe84d1
https://escholarship.org/uc/item/17s8j2zw

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Pharmacodynamics of PI3K, MEK, and AKT inhibitors through isoform-specific measurements of MEK, ERK, AKT, and ribosomal protein S6 in needle biopsies

Autor: Casey L. Kilpatrick, Howard Stotler, James H. Doroshow, Dominic Esposito, Ralph E. Parchment, William Herrick, Melinda G. Hollingshead, Apurva K. Srivastava

Publikováno v: Journal of Clinical Oncology. 37:3134-3134

3134 Background: The success of drugs targeting the MAPK or PI3K pathways in cancer has been slowed by insufficient pathway suppression or onset of resistance through rebound or cross-pathway activation. Isoform-specific measurement of key signaling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f919f5698bd882eeb2551d33c2d65500
https://doi.org/10.1200/jco.2019.37.15_suppl.3134

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GABAA Receptor Trafficking-Mediated Plasticity of Inhibitory Synapses

Autor: Thomas Fuchs, Casey L. Kilpatrick, Bernhard Lüscher

Publikováno v: Neuron. 70:385-409

Proper developmental, neural cell-type-specific, and activity-dependent regulation of GABAergic transmission is essential for virtually all aspects of CNS function. The number of GABA(A) receptors in the postsynaptic membrane directly controls the ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4b70d11eb442063e94ba99ec80c7aa
https://doi.org/10.1016/j.neuron.2011.03.024

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Abstract B081: Elucidating the pharmacodynamics of PI3K and Ras-Raf signaling through isoform-specific multiplexed quantification of downstream effector phosphorylation

Autor: James H. Doroshow, Casey L. Kilpatrick, Apurva K. Srivastava, Ralph E. Parchment, Melinda G. Hollingshead, William Herrick

Publikováno v: Molecular Cancer Therapeutics. 17:B081-B081

Background: Ras-extracellular signal-regulated kinase (Ras-ERK) and phosphatidylinositol 3-kinase/AKT (PI3K/AKT) signaling pathways are signal transducers that influence many cell functions, making them attractive targets for therapeutic development.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6881eeb647a200f35c50d9e3c20a7437
https://doi.org/10.1158/1535-7163.targ-17-b081

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