Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Casey J. Brewer"'
Autor:
Lianjun Zhang, Le Xuan Truong Nguyen, Ying-Chieh Chen, Dijiong Wu, Guerry J. Cook, Dinh Hoa Hoang, Casey J. Brewer, Xin He, Haojie Dong, Shu Li, Man Li, Dandan Zhao, Jing Qi, Wei-Kai Hua, Qi Cai, Emily Carnahan, Wei Chen, Xiwei Wu, Piotr Swiderski, Russell C. Rockne, Marcin Kortylewski, Ling Li, Bin Zhang, Guido Marcucci, Ya-Huei Kuo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
miR-126 is highly expressed in inv(16) Acute myeloid leukemia (AML) but its role is unclear. Here, the authors show that the aberrant expression of miR-126 in inv(16) AML is directly due to the CBFB-MYH11 fusion gene and that it can promote AML devel
Externí odkaz:
https://doaj.org/article/ba8150db19cd424e95fcc1bef2ef61ff
Autor:
Wei-Kai Hua, Xiwei Wu, Ying-Chieh Chen, Guido Marcucci, Russell C. Rockne, Emily Carnahan, Dijiong Wu, Qi Cai, Xin He, Man Li, Lianjun Zhang, Guerry J. Cook, Dinh Hoa Hoang, Piotr Swiderski, Jing Qi, Marcin Kortylewski, Shu Li, Le Xuan Truong Nguyen, Haojie Dong, Dandan Zhao, Casey J Brewer, Bin Zhang, Wei Chen, Ya-Huei Kuo, Ling Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications
Acute myeloid leukemia (AML) harboring inv(16)(p13q22) expresses high levels of miR-126. Here we show that the CBFB-MYH11 (CM) fusion gene upregulates miR-126 expression through aberrant miR-126 transcription and perturbed miR-126 biogenesis via the
Autor:
Elizabeth K. Baker, Casey J. Brewer, Leonardo Ferreira, Mark Schapiro, Jeffrey Tenney, Heather M. Wied, Beth M. Kline‐Fath, Teresa A. Smolarek, K. Nicole Weaver, Robert J. Hopkin
Publikováno v:
American journal of medical genetics. Part AREFERENCES.
Deletion of 17p13.3 has varying degrees of severity on brain development based on precise location and size of the deletion. The most severe phenotype is Miller-Dieker syndrome (MDS) which is characterized by lissencephaly, dysmorphic facial features
Autor:
Bin Zhang, Mhairi Copland, Herman Wu, Stephen J. Forman, Dandan Zhao, Ravi Bhatia, Huafeng Wang, Guido Marcucci, Le Xuan Truong Nguyen, Adrienne M. Dorrance, David S. Snyder, Piotr Swiderski, Tessa L. Holyoake, Ching-Cheng Chen, Vinod Pullarkat, Allen Lin, Bijender Kumar, Lisa E. M. Hopcroft, Tinisha McDonald, Haris Ali, Anthony S. Stein, Francesca Pellicano, Estelle Troadec, Danilo Perrotti, Nadia Carlesso, Casey J Brewer, Ya-Huei Kuo, Ling Li, Marcin Kortylewski, Calvin J. Kuo, Yu-Lin Su, Yate Ching Yuan
Publikováno v:
Nature medicine
Leukemia stem cells (LSCs) in individuals with chronic myelogenous leukemia (CML) (hereafter referred to as CML LSCs) are responsible for initiating and maintaining clonal hematopoiesis. These cells persist in the bone marrow (BM) despite effective i
Autor:
Joseph Fierro, Casey J Brewer, Hanlin Gao, Hai-Yun Yen, Jie Mickey Li, William A Scaringe, Che-Yu Lee, Samuel P. Strom, Meghan Gillespie
Publikováno v:
The Journal of molecular diagnostics : JMD. 22(5)
When a potential disease-causing variant is detected in a proband, parental testing is used to determine the mode of inheritance. This study demonstrates that next-generation sequencing (NGS) is uniquely well suited for parental testing, in particula
Autor:
Bin Zhang, Guerry J. Cook, Herman Wu, Ya-Huei Kuo, Ling Li, Dijiong Wu, Casey J Brewer, Man Li, Marcin Kortylewski, Guido Marcucci, Jing Qi, Le Xuan Truong Nguyen, Xin He, Lianjun Zhang, Dandan Zhao
Publikováno v:
Blood. 134:3914-3914
Inv(16)(p13q22) or t(16;16)(p13.1;q22) [hereafter inv(16)], a chromosomal rearrangement occurred in 5-12% acute myeloid leukemia (AML) patients, disrupts the core-binding factor (CBF) transcription complex and creates a leukemogenic fusion gene CBFb-
Autor:
Herman Wu, Yate-Ching Yuan, Guerry J. Cook, Xiwei Wu, Lianjun Zhang, Stephen J. Forman, Davide Maestrini, Russell C. Rockne, Nadia Carlesso, Le Xuan Nguyen, Casey J Brewer, Denis O’Meally, Ya-Huei Kuo, Dijiong Wu, Ayelet Marmon, Bin Zhang, Maria Ayala Ramirez, Man Li, Emily Carnahan, Jing Qi, Guido Marcucci, Sergio Branciamore, Wei-Kai Hua
Publikováno v:
Experimental Hematology. 64:S78