Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Casey D Charvet"'
Autor:
Wenchao Zheng, Rachel E Reem, Saida Omarova, Suber Huang, Pier Luigi DiPatre, Casey D Charvet, Christine A Curcio, Irina A Pikuleva
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37926 (2012)
The retina is a light-sensitive tissue lining the inner surface of the eye and one of the few human organs whose cholesterol maintenance is still poorly understood. Challenges in studies of the retina include its complex multicellular and multilayere
Externí odkaz:
https://doaj.org/article/872fa06f2eb64cddbfd836f2aa3935ff
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 5, Pp 1421-1429 (2013)
Posttranslational modification by isolevuglandins (isoLGs), arachidonate oxidation products, is an important yet understudied process associated with altered protein properties. This type of modification is detected in cytochrome P450 27A1 (CYP27A1),
Externí odkaz:
https://doaj.org/article/052c1107915942faad73caaf4ea2ac8b
Autor:
Gun Young Heo, James Laird, Irina A. Pikuleva, Robert G. Salomon, Wei Li Liao, Illarion V. Turko, Casey D. Charvet
Publikováno v:
Journal of Biological Chemistry. 286:20413-20422
We report the first peptide mapping and sequencing of an in vivo isolevuglandin-modified protein. Mitochondrial cytochrome P450 27A1 (CYP27A1) is a ubiquitous multifunctional sterol C27-hydroxylase that eliminates cholesterol and likely 7-ketocholest
Publikováno v:
Analytical Biochemistry. 411:254-260
The casitas B-lineage lymphoma (Cbl) proteins play an important role in regulating signal transduction pathways by functioning as E3 ubiquitin ligases. The Cbl proteins contain a conserved tyrosine kinase binding (TKB) domain that binds more than a d
Autor:
Casey D. Charvet, Irina A. Pikuleva
Publikováno v:
Advanced Protocols in Oxidative Stress III ISBN: 9781493914401
The aging process seems to be associated with oxidative stress and hence increased production of lipid peroxidation products, including isolevuglandins (isoLGs). The latter are highly reactive γ-ketoaldehydes which can form covalent adducts with pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f35492114eb1a0cdaac3d98d6cbdd4a
https://europepmc.org/articles/PMC4241500/
https://europepmc.org/articles/PMC4241500/
Autor:
Casey D. Charvet, Timothy S. Kern, Aicha Saadane, Saida Omarova, Wenchao Zheng, Natalia Mast, Irina A. Pikuleva, Neal S. Peachey, Suber S. Huang
Publikováno v:
The American journal of pathology, vol 184, iss 9
Cholesterol elimination from nonhepatic cells involves metabolism to side-chain oxysterols, which serve as transport forms of cholesterol and bioactive molecules modulating a variety of cellular processes. Cholesterol metabolism is tissue specific, a
Autor:
Irina A. Pikuleva, Christine A. Curcio, Saida Omarova, Rachel E. Reem, Pier Luigi DiPatre, Suber S. Huang, Casey D. Charvet, Wenchao Zheng
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37926 (2012)
PLoS ONE
PLoS ONE
Background The retina is a light-sensitive tissue lining the inner surface of the eye and one of the few human organs whose cholesterol maintenance is still poorly understood. Challenges in studies of the retina include its complex multicellular and
Cytochrome P450 46A1 (CYP46A1) initiates the major pathway of cholesterol elimination from the brain and thereby controls cholesterol turnover in this organ. We determined x-ray crystal structures of CYP46A1 in complex with four structurally distinct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f64882d1d72381ce12ea6de5d37aa5
https://europepmc.org/articles/PMC2951250/
https://europepmc.org/articles/PMC2951250/
Publikováno v:
SIGGRAPH Abstracts and Applications
Publikováno v:
ACM SIGGRAPH Computer Graphics. 31:64-65