Výsledky vyhledávání - "Casey Capparelli"

Osteoprotegerin Reverses Osteoporosis by Inhibiting Endosteal Osteoclasts and Prevents Vascular Calcification by Blocking a Process Resembling Osteoclastogenesis

Autor: Ildiko Sarosi, Sheila Scully, Colin R. Dunstan, Paul J. Kostenuik, Casey Capparelli, Sean Morony, W. Scott Simonet, David L. Lacey, William J. Boyle, Hosung Min, Gwyneth Van, Steve Kaufman

Publikováno v: The Journal of Experimental Medicine

High systemic levels of osteoprotegerin (OPG) in OPG transgenic mice cause osteopetrosis with normal tooth eruption and bone elongation and inhibit the development and activity of endosteal, but not periosteal, osteoclasts. We demonstrate that both i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e45f835a2e4cfd50381cbd46d4aaa7
https://doi.org/10.1084/jem.192.4.463

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Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

Publikováno v: ResearcherID

Bone remodelling and bone loss are controlled by a balance between the tumour necrosis factor family molecule osteoprotegerin ligand (OPGL) and its decoy receptor osteoprotegerin (OPG)1,2,3. In addition, OPGL regulates lymph node organogenesis, lymph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf36ee6e5ef05011548a2e4b602200e0
https://doi.org/10.1038/35005552

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Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

Publikováno v: Proceedings of the National Academy of Sciences. 96:3540-3545

A receptor that mediates osteoprotegerin ligand (OPGL)-induced osteoclast differentiation and activation has been identified via genomic analysis of a primary osteoclast precursor cell cDNA library and is identical to the tumor necrosis factor recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01e7505cc521eabdba3836c11e1c159
https://doi.org/10.1073/pnas.96.7.3540

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Apoptosis during bone-like tissue development in vitro

Autor: Janet L. Stein, Jane B. Lian, Maureen P. Lynch, Casey Capparelli, Gary S. Stein

Publikováno v: Journal of Cellular Biochemistry. 68:31-49

We present evidence of cell death by apoptosis during the development of bone-like tissue formation in vitro. Fetal rat calvaria-derived osteoblasts differentiate in vitro, progressing through three stages of maturation: a proliferation period, a mat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2081697fcd475d1a2714006995a7791a
https://doi.org/10.1002/(sici)1097-4644(19980101)68:1<31::aid-jcb4>3.0.co

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Acidic fibroblast growth factor inhibits osteoblast differentiation in vitro: Altered expression of collagenase, cell growth-related, and mineralization-associated genes

Autor: Jane B. Lian, Gary S. Stein, Kam-Tsun Tang, William J. DeVito, Casey Capparelli, Anna C. Huber, Janet L. Stein, Lewis E. Braverman

Publikováno v: Journal of Cellular Biochemistry. 61:152-166

Fibroblast growth factors (FGF) are osteoblast mitogens, but their effects on bone formation are not clearly understood. Most in vitro studies examining the effects of FGFs on osteoblasts have been performed only during the initial proliferative stag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::64a72c6ed0be7346540661511a2240af
https://doi.org/10.1002/(sici)1097-4644(19960401)61:1<152::aid-jcb16>3.0.co

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The inhibition of RANKL causes greater suppression of bone resorption and hypercalcemia compared with bisphosphonates in two models of humoral hypercalcemia of malignancy

Autor: Colin R. Dunstan, Hong Lin Tan, Bernadette Weimann, Paul J. Kostenuik, Stephen Adamu, Zhaopo Geng, Mario Grisanti, Casey Capparelli, Kelly S Warmington, Sean Morony, Charlie Starnes, Frank Asuncion

Publikováno v: Endocrinology. 146(8)

Humoral hypercalcemia of malignancy (HHM) is mediated primarily by skeletal and renal responses to tumor-derived PTHrP. PTHrP mobilizes calcium from bone by inducing the expression of receptor activator for nuclear factor-κB ligand (RANKL), a protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4c8aa7dab3868d1af7d0585adbf90f
https://pubmed.ncbi.nlm.nih.gov/16009971

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OPG and PTH-(1-34) have additive effects on bone density and mechanical strength in osteopenic ovariectomized rats

Autor: David L. Lacey, Stephen Adamu, Colin R. Dunstan, Casey Capparelli, Victor Shen, Grant Shimamoto, Paul J. Kostenuik, Sean Morony

Publikováno v: Endocrinology. 142(10)

PTH is a potent bone anabolic factor, and its combination with antiresorptive agents has been proposed as a therapy for osteoporosis. We tested the effects of PTH, alone and in combination with the novel antiresorptive agent OPG, in a rat model of se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0577f5bd94e43bf513620ebb96f2218c
https://pubmed.ncbi.nlm.nih.gov/11564687

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Adenoviral delivery of osteoprotegerin ameliorates bone resorption in a mouse ovariectomy model of osteoporosis

Autor: Mark Daris, Mingfu Mao, Angela Hsieh, Colin R. Dunstan, Casey Capparelli, Brad Bolon, Sean Morony, Christopher Carter, David L. Lacey, Jackie Sheng, Paul J. Kostenuik

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy. 3(2)

Osteoprotegerin (OPG) regulates bone resorption by inhibiting osteoclast formation, function, and survival. The current studies employed a mouse ovariectomy (OVX) model of estrogen deficiency to investigate gene therapy with OPG as a means of prevent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1bfdd6a6aca1f995aa59894ddc24895
https://pubmed.ncbi.nlm.nih.gov/11237676

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RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 97(4)

We have generated RANK (receptor activator of NF-κB) nullizygous mice to determine the molecular genetic interactions between osteoprotegerin, osteoprotegerin ligand, and RANK during bone resorption and remodeling processes. RANK −/− mice lack o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e6ad89897ee30aaf72fefd0f881085
https://pubmed.ncbi.nlm.nih.gov/10677500

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A chimeric form of osteoprotegerin inhibits hypercalcemia and bone resorption induced by IL-1beta, TNF-alpha, PTH, PTHrP, and 1, 25(OH)2D3

Autor: Colin R. Dunstan, Thomas C. Boone, David L. Lacey, Richard Lee, Sean Morony, Casey Capparelli, Grant Shimamoto

Publikováno v: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 14(9)

Osteoprotegerin (OPG) is a secreted protein that inhibits osteoclast formation and activity and appears to be a critical regulator of bone mass and metabolism. In the current study, mice were challenged with various cytokines and hormones (interleuki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64aeb823f8fe951ba87e0d4fa4f39460
https://pubmed.ncbi.nlm.nih.gov/10469275

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